GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report

Kenjiro Date, Takao Ohtsuka, Takaaki Fujimoto, Yoshitaka Gotoh, Yohei Nakashima, Hideyo Kimura, Taketo Matsunaga, Yasuhisa Mori, Naoki Mochidome, Tetsuyuki Miyazaki, Yoshinao Oda, Masao Tanaka, Masafumi Nakamura

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3 Citations (Scopus)

Abstract

Intraductal papillary mucinous neoplasm (IPMN) of the pancreas and intraductal papillary neoplasm of the bile duct (IPNB) are considered as counterparts of each other, and it is suggested that these two entities have similar molecular alteration pathways. However, the occurrence of IPMN of the pancreas and IPNB in the same patient is rare. We report a surgical case of a 69-year-old woman who developed invasive IPMN of the pancreas and underwent pancreatectomy, 6 months after hepatic resection of invasive IPNB. Molecular analysis revealed GNAS/KRAS mutation in both invasive IPMN of the pancreas and IPNB. This is believed to be the first case report investigating GNAS/KRAS mutational status in both IPMN of the pancreas and IPNB developing in the same patient, and these two entities may show similar molecular alternations.

Original languageEnglish
Pages (from-to)713-716
Number of pages4
JournalPancreatology
Volume15
Issue number6
DOIs
Publication statusPublished - 2015

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Gastroenterology

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    Date, K., Ohtsuka, T., Fujimoto, T., Gotoh, Y., Nakashima, Y., Kimura, H., Matsunaga, T., Mori, Y., Mochidome, N., Miyazaki, T., Oda, Y., Tanaka, M., & Nakamura, M. (2015). GNAS and KRAS mutational analyses of intraductal papillary neoplasms of the pancreas and bile duct developing in the same individual: A case report. Pancreatology, 15(6), 713-716. https://doi.org/10.1016/j.pan.2015.09.013