Gold nanoparticles modified with double-stranded DNA for analytical applications

Tohru Takarada, Mizuo Maeda

Research output: Contribution to journalArticle


Gold naoparticles densely functionalized with a DNA duplex undergo rapid and spontaneous aggregation in a medium of relatively high ionic strength. This non-crosslinking aggregation occurs irrespective of the particle size and the DNA length, while it exhibits both greater temperature- and salt concentration-dependence than that of DNA duplex formation. Interestingly, no aggregation takes place under the same conditions when the DNA duplex has a single-base mismatch at the distal end, which is located at the outermost surface of the particle. In this review, we describe applications of the DNA-carrying gold nanoparticles to gene diagnosis and chemical sensing, with emphasis placed on some attempts to improve the sensitivity.

Original languageEnglish
Pages (from-to)15-23
Number of pages9
Journalbunseki kagaku
Issue number1
Publication statusPublished - Jan 1 2015
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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