Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice

Keisuke Nose, Dakrong Pissuwan, Masahiro Goto, Yoshiki Katayama, Takuro Niidome

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Efficient transdermal insulin delivery to the systemic circulation would bring major benefit to diabetic patients. We investigated the possibility of using gold nanorods (GNRs) that formed a complex with an edible surfactant and insulin (INS) in an oil phase to form a solid-in-oil (SO) formulation (SO-INS-GNR) for transdermal treatment of diabetes. Diabetic mice comprised the model for our study. In vitro, there was high penetration of insulin through the stratum corneum (SC) and the dermis in mouse skin treated with an SO-INS-GNR complex plus near-infrared (NIR) light irradiation. Blood glucose levels in the diabetic mice were significantly decreased after treatment with SO-INS-GNR plus irradiation. To our knowledge, this is the first study to use gold nanorods for systemic insulin delivery through the skin. The use of an SO-INS-GNR complex combined with NIR irradiation may provide the possibility of transdermal insulin delivery to diabetic patients.

Original languageEnglish
Pages (from-to)3776-3780
Number of pages5
JournalNanoscale
Volume4
Issue number12
DOIs
Publication statusPublished - Jun 12 2012

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

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