Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice

Keisuke Nose, Dakrong Pissuwan, Masahiro Goto, Yoshiki Katayama, Takuro Niidome

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Efficient transdermal insulin delivery to the systemic circulation would bring major benefit to diabetic patients. We investigated the possibility of using gold nanorods (GNRs) that formed a complex with an edible surfactant and insulin (INS) in an oil phase to form a solid-in-oil (SO) formulation (SO-INS-GNR) for transdermal treatment of diabetes. Diabetic mice comprised the model for our study. In vitro, there was high penetration of insulin through the stratum corneum (SC) and the dermis in mouse skin treated with an SO-INS-GNR complex plus near-infrared (NIR) light irradiation. Blood glucose levels in the diabetic mice were significantly decreased after treatment with SO-INS-GNR plus irradiation. To our knowledge, this is the first study to use gold nanorods for systemic insulin delivery through the skin. The use of an SO-INS-GNR complex combined with NIR irradiation may provide the possibility of transdermal insulin delivery to diabetic patients.

Original languageEnglish
Pages (from-to)3776-3780
Number of pages5
JournalNanoscale
Volume4
Issue number12
DOIs
Publication statusPublished - Jun 12 2012

Fingerprint

Insulin
Medical problems
Nanorods
Gold
Oils
Irradiation
Skin
Infrared radiation
Surface-Active Agents
Glucose
Blood Glucose
Surface active agents
Blood

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice. / Nose, Keisuke; Pissuwan, Dakrong; Goto, Masahiro; Katayama, Yoshiki; Niidome, Takuro.

In: Nanoscale, Vol. 4, No. 12, 12.06.2012, p. 3776-3780.

Research output: Contribution to journalArticle

Nose, Keisuke ; Pissuwan, Dakrong ; Goto, Masahiro ; Katayama, Yoshiki ; Niidome, Takuro. / Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice. In: Nanoscale. 2012 ; Vol. 4, No. 12. pp. 3776-3780.
@article{6644c180abad4985b4c0602da29fbba1,
title = "Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice",
abstract = "Efficient transdermal insulin delivery to the systemic circulation would bring major benefit to diabetic patients. We investigated the possibility of using gold nanorods (GNRs) that formed a complex with an edible surfactant and insulin (INS) in an oil phase to form a solid-in-oil (SO) formulation (SO-INS-GNR) for transdermal treatment of diabetes. Diabetic mice comprised the model for our study. In vitro, there was high penetration of insulin through the stratum corneum (SC) and the dermis in mouse skin treated with an SO-INS-GNR complex plus near-infrared (NIR) light irradiation. Blood glucose levels in the diabetic mice were significantly decreased after treatment with SO-INS-GNR plus irradiation. To our knowledge, this is the first study to use gold nanorods for systemic insulin delivery through the skin. The use of an SO-INS-GNR complex combined with NIR irradiation may provide the possibility of transdermal insulin delivery to diabetic patients.",
author = "Keisuke Nose and Dakrong Pissuwan and Masahiro Goto and Yoshiki Katayama and Takuro Niidome",
year = "2012",
month = "6",
day = "12",
doi = "10.1039/c2nr30651d",
language = "English",
volume = "4",
pages = "3776--3780",
journal = "Nanoscale",
issn = "2040-3364",
publisher = "Royal Society of Chemistry",
number = "12",

}

TY - JOUR

T1 - Gold nanorods in an oil-base formulation for transdermal treatment of type 1 diabetes in mice

AU - Nose, Keisuke

AU - Pissuwan, Dakrong

AU - Goto, Masahiro

AU - Katayama, Yoshiki

AU - Niidome, Takuro

PY - 2012/6/12

Y1 - 2012/6/12

N2 - Efficient transdermal insulin delivery to the systemic circulation would bring major benefit to diabetic patients. We investigated the possibility of using gold nanorods (GNRs) that formed a complex with an edible surfactant and insulin (INS) in an oil phase to form a solid-in-oil (SO) formulation (SO-INS-GNR) for transdermal treatment of diabetes. Diabetic mice comprised the model for our study. In vitro, there was high penetration of insulin through the stratum corneum (SC) and the dermis in mouse skin treated with an SO-INS-GNR complex plus near-infrared (NIR) light irradiation. Blood glucose levels in the diabetic mice were significantly decreased after treatment with SO-INS-GNR plus irradiation. To our knowledge, this is the first study to use gold nanorods for systemic insulin delivery through the skin. The use of an SO-INS-GNR complex combined with NIR irradiation may provide the possibility of transdermal insulin delivery to diabetic patients.

AB - Efficient transdermal insulin delivery to the systemic circulation would bring major benefit to diabetic patients. We investigated the possibility of using gold nanorods (GNRs) that formed a complex with an edible surfactant and insulin (INS) in an oil phase to form a solid-in-oil (SO) formulation (SO-INS-GNR) for transdermal treatment of diabetes. Diabetic mice comprised the model for our study. In vitro, there was high penetration of insulin through the stratum corneum (SC) and the dermis in mouse skin treated with an SO-INS-GNR complex plus near-infrared (NIR) light irradiation. Blood glucose levels in the diabetic mice were significantly decreased after treatment with SO-INS-GNR plus irradiation. To our knowledge, this is the first study to use gold nanorods for systemic insulin delivery through the skin. The use of an SO-INS-GNR complex combined with NIR irradiation may provide the possibility of transdermal insulin delivery to diabetic patients.

UR - http://www.scopus.com/inward/record.url?scp=84867396181&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84867396181&partnerID=8YFLogxK

U2 - 10.1039/c2nr30651d

DO - 10.1039/c2nr30651d

M3 - Article

C2 - 22622618

AN - SCOPUS:84867396181

VL - 4

SP - 3776

EP - 3780

JO - Nanoscale

JF - Nanoscale

SN - 2040-3364

IS - 12

ER -