Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats

Possible involvement of kappa opioid receptor

Hitomi Higuchi, Shota Yamamoto, Soichiro Ushio, takehiro kawashiri, Nobuaki Egashira

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In the present study, we investigated the effect of a Kampo medicine Goshajinkigan (GJG) on the bortezomib-induced mechanical allodynia in von Frey test in rats. The single administration of tramadol (10 mg/kg), GJG (1.0 g/kg) and its component processed Aconiti tuber (0.1 g/kg) significantly reversed the reduction in withdrawal threshold by bortezomib. These effects were abolished by the intrathecal injection of nor-binaltorphimine (10 μg/body), kappa opioid receptor antagonist. These findings suggest that kappa opioid receptor is involved in the effect of GJG on the bortezomib-induced mechanical allodynia.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalJournal of Pharmacological Sciences
Volume129
Issue number3
DOIs
Publication statusPublished - Nov 1 2015

Fingerprint

kappa Opioid Receptor
Hyperalgesia
Kampo Medicine
Tramadol
Spinal Injections
Narcotic Antagonists
Bortezomib
gosha-jinki-gan

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats : Possible involvement of kappa opioid receptor. / Higuchi, Hitomi; Yamamoto, Shota; Ushio, Soichiro; kawashiri, takehiro; Egashira, Nobuaki.

In: Journal of Pharmacological Sciences, Vol. 129, No. 3, 01.11.2015, p. 196-199.

Research output: Contribution to journalArticle

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