Goshajinkigan reduces bortezomib-induced mechanical allodynia in rats: Possible involvement of kappa opioid receptor

Hitomi Higuchi, Shota Yamamoto, Soichiro Ushio, takehiro kawashiri, Nobuaki Egashira

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Abstract

In the present study, we investigated the effect of a Kampo medicine Goshajinkigan (GJG) on the bortezomib-induced mechanical allodynia in von Frey test in rats. The single administration of tramadol (10 mg/kg), GJG (1.0 g/kg) and its component processed Aconiti tuber (0.1 g/kg) significantly reversed the reduction in withdrawal threshold by bortezomib. These effects were abolished by the intrathecal injection of nor-binaltorphimine (10 μg/body), kappa opioid receptor antagonist. These findings suggest that kappa opioid receptor is involved in the effect of GJG on the bortezomib-induced mechanical allodynia.

Original languageEnglish
Pages (from-to)196-199
Number of pages4
JournalJournal of Pharmacological Sciences
Volume129
Issue number3
DOIs
Publication statusPublished - Nov 1 2015

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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