Graft selection strategy in adult-to-adult living donor liver transplantation

When both hemiliver grafts meet volumetric criteria

Takeshi Kurihara, Tomoharu Yoshizumi, Yoshihiro Yoshida, Toru Ikegami, shinji itoh, Norifumi Harimoto, Mizuki Ninomiya, Hideaki Uchiyama, Hirohisa Okabe, Koichi Kimura, Hirofumi Kawanaka, Ken Shirabe, Yoshihiko Maehara

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To ensure donor safety in living donor liver transplantation (LDLT), the left and caudate lobe (LL) is the preferred graft choice. However, patient prognosis may still be poor even if graft volume (GV) selection criteria are met. Our aim was to evaluate the effects of right lobe (RL) donation when the LL graft selection criteria are met. Consecutive donors (n = 135) with preoperative LL graft volumetric GV/standard liver volume (SLV) of ≥35% and RL remnant of ≥35% were retrospectively studied. Patients were divided into 2 groups: LL graft and RL graft. Recipient's body surface area (BSA), Model for End-Stage Liver Disease (MELD) score, and the donor's age were higher in the RL group. The donor's BSA and preoperative volumetric GV/SLV of the LL graft were smaller in the RL group. The predicted score (calculated using data for graft size, donor age, MELD score, and the presence of portosystemic shunt, which correlated well with graft function and with 6-month graft survival) of the RL group, was significantly lower if the LL graft were used, but using the actual RL graft improved the score equal to that of the LL group. Six-month and 12-month graft survival rates did not differ between the 2 groups. In patients with a poor prognosis, a larger RL graft improved the predicted score and survival was equal to that of patients who received LL grafts. In conclusion, graft selection by GV, donor age, and recipient MELD score improves outcomes in LDLT. Liver Transplantation 22 914–922 2016 AASLD.

Original languageEnglish
Pages (from-to)914-922
Number of pages9
JournalLiver Transplantation
Volume22
Issue number7
DOIs
Publication statusPublished - Jul 1 2016

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Living Donors
Liver Transplantation
Transplants
Tissue Donors
End Stage Liver Disease
Body Surface Area
Graft Survival
Patient Selection
Surgical Portasystemic Shunt
Liver

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology
  • Transplantation

Cite this

Graft selection strategy in adult-to-adult living donor liver transplantation : When both hemiliver grafts meet volumetric criteria. / Kurihara, Takeshi; Yoshizumi, Tomoharu; Yoshida, Yoshihiro; Ikegami, Toru; itoh, shinji; Harimoto, Norifumi; Ninomiya, Mizuki; Uchiyama, Hideaki; Okabe, Hirohisa; Kimura, Koichi; Kawanaka, Hirofumi; Shirabe, Ken; Maehara, Yoshihiko.

In: Liver Transplantation, Vol. 22, No. 7, 01.07.2016, p. 914-922.

Research output: Contribution to journalArticle

Kurihara, T, Yoshizumi, T, Yoshida, Y, Ikegami, T, itoh, S, Harimoto, N, Ninomiya, M, Uchiyama, H, Okabe, H, Kimura, K, Kawanaka, H, Shirabe, K & Maehara, Y 2016, 'Graft selection strategy in adult-to-adult living donor liver transplantation: When both hemiliver grafts meet volumetric criteria', Liver Transplantation, vol. 22, no. 7, pp. 914-922. https://doi.org/10.1002/lt.24431
Kurihara, Takeshi ; Yoshizumi, Tomoharu ; Yoshida, Yoshihiro ; Ikegami, Toru ; itoh, shinji ; Harimoto, Norifumi ; Ninomiya, Mizuki ; Uchiyama, Hideaki ; Okabe, Hirohisa ; Kimura, Koichi ; Kawanaka, Hirofumi ; Shirabe, Ken ; Maehara, Yoshihiko. / Graft selection strategy in adult-to-adult living donor liver transplantation : When both hemiliver grafts meet volumetric criteria. In: Liver Transplantation. 2016 ; Vol. 22, No. 7. pp. 914-922.
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AU - Kawanaka, Hirofumi

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