Graft size, donor age, and patient status are the indicators of early graft function after living donor liver transplantation

Tomoharu Yoshizumi, Akinobu Taketomi, Hideaki Uchiyama, Noboru Harada, Hiroto Kayashima, Yo Ichi Yamashita, Yuji Soejima, Mitsuo Shimada, Yoshihiko Maehara

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

No reliable model for predicting early graft function and patient survival after living donor liver transplantation (LDLT) exists. The aim of this study was to establish a new formula for predicting early graft function and prognosis using technetium-99m galactosyl-human serum albumin (Tc-GSA) liver scintigraphy. The ratio of the hepatic uptake ratio of Tc-GSA to the clearance index of Tc-GSA (LHL/HH) was determined 7 days after LDLT. There were 22 patients with a ratio greater than 1.3 and 6 patients with a ratio less than 1.3. Graft function on the 14th postoperative day (POD) was compared between the 2 groups. A new formula to predict the LHL/HH score was established as follows: LHL/HH (predictive score) = 0.011 × graft weight (%) - 0.016 × donor age - 0.008 × Model for End-Stage Liver Disease score - 0. 15 × shunt (if present) + 1.757 (r2 = 0.497, P < 0.01). This predicted LHL/HH ratio was compared to the graft function on POD 14 for 110 LDLT patients. The total bilirubin JB) and prothrombin time international normalized ratio (PT-INR) in the group with an LHL/HH score ≥ 1.3 were lower than those in the group with an LHL/HH score < 1.3. The TB, PT-INR, and volume of ascites in the group with a predictive score ≥ 1.3 (n = 86) were lower than those in the group with a score < 1.3 (n = 24). The 6-month survival probability was improved in the group with a predictive score ≥ 1.3. In conclusion, this preoperative calculated LHL/HH score is correlated with graft function and short-term prognosis. Thus, this predictive model may allow transplant surgeons to use a living donor left lobe graft with greater confidence.

Original languageEnglish
Pages (from-to)1007-1013
Number of pages7
JournalLiver Transplantation
Volume14
Issue number7
DOIs
Publication statusPublished - Jul 1 2008

Fingerprint

Living Donors
Liver Transplantation
Tissue Donors
Transplants
Technetium
Serum Albumin
International Normalized Ratio
Prothrombin Time
End Stage Liver Disease
Survival
Liver
Bilirubin
Ascites
Radionuclide Imaging
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Surgery
  • Hepatology
  • Transplantation

Cite this

Graft size, donor age, and patient status are the indicators of early graft function after living donor liver transplantation. / Yoshizumi, Tomoharu; Taketomi, Akinobu; Uchiyama, Hideaki; Harada, Noboru; Kayashima, Hiroto; Yamashita, Yo Ichi; Soejima, Yuji; Shimada, Mitsuo; Maehara, Yoshihiko.

In: Liver Transplantation, Vol. 14, No. 7, 01.07.2008, p. 1007-1013.

Research output: Contribution to journalArticle

Yoshizumi, T, Taketomi, A, Uchiyama, H, Harada, N, Kayashima, H, Yamashita, YI, Soejima, Y, Shimada, M & Maehara, Y 2008, 'Graft size, donor age, and patient status are the indicators of early graft function after living donor liver transplantation', Liver Transplantation, vol. 14, no. 7, pp. 1007-1013. https://doi.org/10.1002/lt.21462
Yoshizumi, Tomoharu ; Taketomi, Akinobu ; Uchiyama, Hideaki ; Harada, Noboru ; Kayashima, Hiroto ; Yamashita, Yo Ichi ; Soejima, Yuji ; Shimada, Mitsuo ; Maehara, Yoshihiko. / Graft size, donor age, and patient status are the indicators of early graft function after living donor liver transplantation. In: Liver Transplantation. 2008 ; Vol. 14, No. 7. pp. 1007-1013.
@article{b2b85839d161424ea264fe4ad9bf63f7,
title = "Graft size, donor age, and patient status are the indicators of early graft function after living donor liver transplantation",
abstract = "No reliable model for predicting early graft function and patient survival after living donor liver transplantation (LDLT) exists. The aim of this study was to establish a new formula for predicting early graft function and prognosis using technetium-99m galactosyl-human serum albumin (Tc-GSA) liver scintigraphy. The ratio of the hepatic uptake ratio of Tc-GSA to the clearance index of Tc-GSA (LHL/HH) was determined 7 days after LDLT. There were 22 patients with a ratio greater than 1.3 and 6 patients with a ratio less than 1.3. Graft function on the 14th postoperative day (POD) was compared between the 2 groups. A new formula to predict the LHL/HH score was established as follows: LHL/HH (predictive score) = 0.011 × graft weight ({\%}) - 0.016 × donor age - 0.008 × Model for End-Stage Liver Disease score - 0. 15 × shunt (if present) + 1.757 (r2 = 0.497, P < 0.01). This predicted LHL/HH ratio was compared to the graft function on POD 14 for 110 LDLT patients. The total bilirubin JB) and prothrombin time international normalized ratio (PT-INR) in the group with an LHL/HH score ≥ 1.3 were lower than those in the group with an LHL/HH score < 1.3. The TB, PT-INR, and volume of ascites in the group with a predictive score ≥ 1.3 (n = 86) were lower than those in the group with a score < 1.3 (n = 24). The 6-month survival probability was improved in the group with a predictive score ≥ 1.3. In conclusion, this preoperative calculated LHL/HH score is correlated with graft function and short-term prognosis. Thus, this predictive model may allow transplant surgeons to use a living donor left lobe graft with greater confidence.",
author = "Tomoharu Yoshizumi and Akinobu Taketomi and Hideaki Uchiyama and Noboru Harada and Hiroto Kayashima and Yamashita, {Yo Ichi} and Yuji Soejima and Mitsuo Shimada and Yoshihiko Maehara",
year = "2008",
month = "7",
day = "1",
doi = "10.1002/lt.21462",
language = "English",
volume = "14",
pages = "1007--1013",
journal = "Liver Transplantation",
issn = "1527-6465",
publisher = "John Wiley and Sons Ltd",
number = "7",

}

TY - JOUR

T1 - Graft size, donor age, and patient status are the indicators of early graft function after living donor liver transplantation

AU - Yoshizumi, Tomoharu

AU - Taketomi, Akinobu

AU - Uchiyama, Hideaki

AU - Harada, Noboru

AU - Kayashima, Hiroto

AU - Yamashita, Yo Ichi

AU - Soejima, Yuji

AU - Shimada, Mitsuo

AU - Maehara, Yoshihiko

PY - 2008/7/1

Y1 - 2008/7/1

N2 - No reliable model for predicting early graft function and patient survival after living donor liver transplantation (LDLT) exists. The aim of this study was to establish a new formula for predicting early graft function and prognosis using technetium-99m galactosyl-human serum albumin (Tc-GSA) liver scintigraphy. The ratio of the hepatic uptake ratio of Tc-GSA to the clearance index of Tc-GSA (LHL/HH) was determined 7 days after LDLT. There were 22 patients with a ratio greater than 1.3 and 6 patients with a ratio less than 1.3. Graft function on the 14th postoperative day (POD) was compared between the 2 groups. A new formula to predict the LHL/HH score was established as follows: LHL/HH (predictive score) = 0.011 × graft weight (%) - 0.016 × donor age - 0.008 × Model for End-Stage Liver Disease score - 0. 15 × shunt (if present) + 1.757 (r2 = 0.497, P < 0.01). This predicted LHL/HH ratio was compared to the graft function on POD 14 for 110 LDLT patients. The total bilirubin JB) and prothrombin time international normalized ratio (PT-INR) in the group with an LHL/HH score ≥ 1.3 were lower than those in the group with an LHL/HH score < 1.3. The TB, PT-INR, and volume of ascites in the group with a predictive score ≥ 1.3 (n = 86) were lower than those in the group with a score < 1.3 (n = 24). The 6-month survival probability was improved in the group with a predictive score ≥ 1.3. In conclusion, this preoperative calculated LHL/HH score is correlated with graft function and short-term prognosis. Thus, this predictive model may allow transplant surgeons to use a living donor left lobe graft with greater confidence.

AB - No reliable model for predicting early graft function and patient survival after living donor liver transplantation (LDLT) exists. The aim of this study was to establish a new formula for predicting early graft function and prognosis using technetium-99m galactosyl-human serum albumin (Tc-GSA) liver scintigraphy. The ratio of the hepatic uptake ratio of Tc-GSA to the clearance index of Tc-GSA (LHL/HH) was determined 7 days after LDLT. There were 22 patients with a ratio greater than 1.3 and 6 patients with a ratio less than 1.3. Graft function on the 14th postoperative day (POD) was compared between the 2 groups. A new formula to predict the LHL/HH score was established as follows: LHL/HH (predictive score) = 0.011 × graft weight (%) - 0.016 × donor age - 0.008 × Model for End-Stage Liver Disease score - 0. 15 × shunt (if present) + 1.757 (r2 = 0.497, P < 0.01). This predicted LHL/HH ratio was compared to the graft function on POD 14 for 110 LDLT patients. The total bilirubin JB) and prothrombin time international normalized ratio (PT-INR) in the group with an LHL/HH score ≥ 1.3 were lower than those in the group with an LHL/HH score < 1.3. The TB, PT-INR, and volume of ascites in the group with a predictive score ≥ 1.3 (n = 86) were lower than those in the group with a score < 1.3 (n = 24). The 6-month survival probability was improved in the group with a predictive score ≥ 1.3. In conclusion, this preoperative calculated LHL/HH score is correlated with graft function and short-term prognosis. Thus, this predictive model may allow transplant surgeons to use a living donor left lobe graft with greater confidence.

UR - http://www.scopus.com/inward/record.url?scp=48949120145&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=48949120145&partnerID=8YFLogxK

U2 - 10.1002/lt.21462

DO - 10.1002/lt.21462

M3 - Article

C2 - 18581462

AN - SCOPUS:48949120145

VL - 14

SP - 1007

EP - 1013

JO - Liver Transplantation

JF - Liver Transplantation

SN - 1527-6465

IS - 7

ER -