Graft-versus-lymphoma effect after reduced intensity allogeneic hematopoietic stem cell transplantation from HLA-two loci mismatched father in a patient with refractory non-Hodgkin lymphoma

Aiko Suminoe, Akinobu Matsuzaki, Yuhki Koga, Miho Hatano, Takuya Hara, Toshiro Hara

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1 Citation (Scopus)

Abstract

A 10-year-old female developed a mediastinal mass and was diagnosed as mixed lineage lymphoblastic lymphoma. The tumor was extremely refractory, and she never achieved remission despite intensive therapy using 12 anti-lymphoma agents and local irradiation. She received reduced-intensity allogeneic peripheral blood stem cell transplantation from her HLA-two loci mismatched father, and achieved complete remission. However, the lymphoma relapsed four months later, and we abruptly discontinued immunosuppressive drugs. Concurrent with the development of grade III graft-versus-host disease, the lymphoma completely disappeared with an increase of activated T-cells in peripheral blood. The clinical course suggested the graft-versus-lymphoma effect against aggressive/refractory lymphoma.

Original languageEnglish
Pages (from-to)500-503
Number of pages4
JournalTurkish Journal of Pediatrics
Volume51
Issue number5
Publication statusPublished - Sep 2009

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

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