Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis

Koichiro Hayashi; Toshiki Yanagisawa; Masaya Shimabukuro; Ryo Kishida; Kunio Ishikawa

doi:10.1016/j.mtbio.2022.100247

Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis

Koichiro Hayashi, Toshiki Yanagisawa, Masaya Shimabukuro, Ryo Kishida, Kunio Ishikawa

Oral Rehabilitation

Research output: Contribution to journal › Article › peer-review

Abstract

Granular porous calcium phosphate scaffolds are used for bone regeneration in dentistry. However, in conventional granules, the macropore interconnectivity is poor and has varying size. Herein, we developed a productive method for fabricating carbonate apatite honeycomb granules with uniformly sized macropores based on extrusion molding. Each honeycomb granule possesses three hexagonal macropores of ∼290 μm along its diagonal. Owing to these macropores, honeycomb granules simultaneously formed new and mature bone and blood vessels in both the interior and exterior of the granules at 4 weeks after implantation. The honeycomb granules are useful for achieving rapid osteogenesis and angiogenesis.

Original language	English
Article number	100247
Journal	Materials Today Bio
Volume	14
DOIs	https://doi.org/10.1016/j.mtbio.2022.100247
Publication status	Published - Mar 2022

All Science Journal Classification (ASJC) codes

Biotechnology
Bioengineering
Biomaterials
Biomedical Engineering
Molecular Biology
Cell Biology

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10.1016/j.mtbio.2022.100247

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title = "Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis",

abstract = "Granular porous calcium phosphate scaffolds are used for bone regeneration in dentistry. However, in conventional granules, the macropore interconnectivity is poor and has varying size. Herein, we developed a productive method for fabricating carbonate apatite honeycomb granules with uniformly sized macropores based on extrusion molding. Each honeycomb granule possesses three hexagonal macropores of ∼290 μm along its diagonal. Owing to these macropores, honeycomb granules simultaneously formed new and mature bone and blood vessels in both the interior and exterior of the granules at 4 weeks after implantation. The honeycomb granules are useful for achieving rapid osteogenesis and angiogenesis.",

author = "Koichiro Hayashi and Toshiki Yanagisawa and Masaya Shimabukuro and Ryo Kishida and Kunio Ishikawa",

note = "Funding Information: The authors acknowledge financial supports from the Japan Agency for Medical Research and Development (AMED) and Japan Society for the Promotion of Science ( JSPS ). Funding Information: This study was supported by the AMED [Grant Numbers JP21im0502004h and JP21he0422005j ] and JSPS [Grant Number JP19K22970 and JP21K17010 ]. Publisher Copyright: {\textcopyright} 2022",

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AU - Hayashi, Koichiro

AU - Yanagisawa, Toshiki

AU - Shimabukuro, Masaya

AU - Kishida, Ryo

AU - Ishikawa, Kunio

N1 - Funding Information: The authors acknowledge financial supports from the Japan Agency for Medical Research and Development (AMED) and Japan Society for the Promotion of Science ( JSPS ). Funding Information: This study was supported by the AMED [Grant Numbers JP21im0502004h and JP21he0422005j ] and JSPS [Grant Number JP19K22970 and JP21K17010 ]. Publisher Copyright: © 2022

PY - 2022/3

Y1 - 2022/3

N2 - Granular porous calcium phosphate scaffolds are used for bone regeneration in dentistry. However, in conventional granules, the macropore interconnectivity is poor and has varying size. Herein, we developed a productive method for fabricating carbonate apatite honeycomb granules with uniformly sized macropores based on extrusion molding. Each honeycomb granule possesses three hexagonal macropores of ∼290 μm along its diagonal. Owing to these macropores, honeycomb granules simultaneously formed new and mature bone and blood vessels in both the interior and exterior of the granules at 4 weeks after implantation. The honeycomb granules are useful for achieving rapid osteogenesis and angiogenesis.

AB - Granular porous calcium phosphate scaffolds are used for bone regeneration in dentistry. However, in conventional granules, the macropore interconnectivity is poor and has varying size. Herein, we developed a productive method for fabricating carbonate apatite honeycomb granules with uniformly sized macropores based on extrusion molding. Each honeycomb granule possesses three hexagonal macropores of ∼290 μm along its diagonal. Owing to these macropores, honeycomb granules simultaneously formed new and mature bone and blood vessels in both the interior and exterior of the granules at 4 weeks after implantation. The honeycomb granules are useful for achieving rapid osteogenesis and angiogenesis.

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Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis

Abstract

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