Granulocyte-colony stimulating factor-producing gallbladder cancer without recurrence more than 2 years after resection: Report of a case

Tetsuo Ikeda, Kippei Ohgaki, Masatoku Miura, Shinichi Aishima, Toshihisa Shimizu, Yoshihiko Maehara

Research output: Contribution to journalArticle

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Abstract

Patients with gallbladder carcinoma rarely have remarkable granulocytosis. Although surgical resection is the most effective treatment, patients with gallbladder carcinoma generally have a very poor prognosis. We report a case of a rapidly growing gallbladder tumor associated with remarkable granulocytosis in a patient who has survived without recurrence for more than 2 years since undergoing resection. The patient had remarkable leukocytosis of 51 500/mm 3 with 89% granulocytes and an elevated granulocyte-colony stimulating factor (G-CSF) level of 800 pg/dl. We performed cholecystectomy with extended right lobectomy of the liver and lymph node dissection. A histological diagnosis of moderately differentiated gallbladder carcinoma with sarcomatous change invading the hepatic parenchyma was confirmed. An immunohistochemical examination using polyclonal antibody against G-CSF was performed to stain the tumor cells, which confirmed the diagnosis of a G-CSF-producing tumor.

Original languageEnglish
Pages (from-to)590-593
Number of pages4
JournalSurgery today
Volume35
Issue number7
DOIs
Publication statusPublished - Jul 1 2005

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Gallbladder Neoplasms
Granulocyte Colony-Stimulating Factor
Gallbladder
Recurrence
Carcinoma
Neoplasms
Liver
Leukocytosis
Cholecystectomy
Lymph Node Excision
Granulocytes
Coloring Agents
Antibodies

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Granulocyte-colony stimulating factor-producing gallbladder cancer without recurrence more than 2 years after resection : Report of a case. / Ikeda, Tetsuo; Ohgaki, Kippei; Miura, Masatoku; Aishima, Shinichi; Shimizu, Toshihisa; Maehara, Yoshihiko.

In: Surgery today, Vol. 35, No. 7, 01.07.2005, p. 590-593.

Research output: Contribution to journalArticle

Ikeda, Tetsuo ; Ohgaki, Kippei ; Miura, Masatoku ; Aishima, Shinichi ; Shimizu, Toshihisa ; Maehara, Yoshihiko. / Granulocyte-colony stimulating factor-producing gallbladder cancer without recurrence more than 2 years after resection : Report of a case. In: Surgery today. 2005 ; Vol. 35, No. 7. pp. 590-593.
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