Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: Report of a case

Mikihiro Kohno, Ken Shirabe, Yohei Mano, Jun Muto, Takashi Motomura, Kazuki Takeishi, Takeo Toshima, Masanori Yoshimatsu, Hideki Ijichi, Noboru Harada, Shinichi Aishima, Hideaki Uchiyama, Tomoharu Yoshizumi, Akinobu Taketomi, Yoshihiko Maehara

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Abstract

This report describes a rare case of hepatocellular carcinoma (HCC) producing granulocyte colony-stimulating factor (G-CSF). A 46-year-old male with chronic hepatitis B, who presented with fever, general malaise, loss of appetite, and weight loss, had a huge liver mass in the portal region. He had marked granulocytosis and his serum level of G-CSF was elevated. Complete tumor resection was performed, and the pathological assessment of the resected specimen revealed HCC with extensive sarcomatous changes and immunohistochemical staining for G-CSF and G-CSF receptor. Only a few cases of G-CSF-producing HCC have been reported, and this is the first case of G-CSF-producing HCC that also expressed G-CSF receptor.

Original languageEnglish
Pages (from-to)439-445
Number of pages7
JournalSurgery today
Volume43
Issue number4
DOIs
Publication statusPublished - Apr 2013

All Science Journal Classification (ASJC) codes

  • Surgery

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    Kohno, M., Shirabe, K., Mano, Y., Muto, J., Motomura, T., Takeishi, K., Toshima, T., Yoshimatsu, M., Ijichi, H., Harada, N., Aishima, S., Uchiyama, H., Yoshizumi, T., Taketomi, A., & Maehara, Y. (2013). Granulocyte colony-stimulating-factor-producing hepatocellular carcinoma with extensive sarcomatous changes: Report of a case. Surgery today, 43(4), 439-445. https://doi.org/10.1007/s00595-012-0202-0