Granulocyte-colony stimulating factor promotes invasion by human lung cancer cell lines in vitro

Xin Hai Pei; Yoichi Nakanishi; Koichi Takayama; Jun Yatsunami; Feng Bai; Masayuki Kawasaki; Kentaro Wakamatsu; Nobuko Tsuruta; Keiko Mizuno; Nobuyuki Hara

doi:10.1007/BF00123394

Granulocyte-colony stimulating factor promotes invasion by human lung cancer cell lines in vitro

Xin Hai Pei, Yoichi Nakanishi, Koichi Takayama, Jun Yatsunami, Feng Bai, Masayuki Kawasaki, Kentaro Wakamatsu, Nobuko Tsuruta, Keiko Mizuno, Nobuyuki Hara

Department of Respirology

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The effects of exogenous and endogenous granulocyte colony-stimulating factor (G-CSF) on invasion by cancer cells were studied, using lung cancer cell lines that produce G-CSF (NCI-H157) and lines that do not (PC-9 and NCI-H23). The invasive capacity of NCI-H157 cells was 26- to 27-fold higher than that of PC-9 and NCI-H23 cells. The invasiveness of PC-9 cells was stimulated by exogenous G-CSF, while that of NCI-H157 cells was not. Antibodies against G-CSF blocked the stimulation of PC-9 cell invasiveness by exogenous G-CSF. Anti G-CSF antibodies also inhibited invasion by NCI-H157 cells in the absence of exogenous G-CSF. These results suggest that endogenous and exogenous G-CSF both stimulate invasion by lung cancer cells.

Original language	English
Pages (from-to)	351-357
Number of pages	7
Journal	Clinical and Experimental Metastasis
Volume	14
Issue number	4
DOIs	https://doi.org/10.1007/BF00123394
Publication status	Published - Nov 11 1996

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

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10.1007/BF00123394

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title = "Granulocyte-colony stimulating factor promotes invasion by human lung cancer cell lines in vitro",

abstract = "The effects of exogenous and endogenous granulocyte colony-stimulating factor (G-CSF) on invasion by cancer cells were studied, using lung cancer cell lines that produce G-CSF (NCI-H157) and lines that do not (PC-9 and NCI-H23). The invasive capacity of NCI-H157 cells was 26- to 27-fold higher than that of PC-9 and NCI-H23 cells. The invasiveness of PC-9 cells was stimulated by exogenous G-CSF, while that of NCI-H157 cells was not. Antibodies against G-CSF blocked the stimulation of PC-9 cell invasiveness by exogenous G-CSF. Anti G-CSF antibodies also inhibited invasion by NCI-H157 cells in the absence of exogenous G-CSF. These results suggest that endogenous and exogenous G-CSF both stimulate invasion by lung cancer cells.",

author = "Pei, {Xin Hai} and Yoichi Nakanishi and Koichi Takayama and Jun Yatsunami and Feng Bai and Masayuki Kawasaki and Kentaro Wakamatsu and Nobuko Tsuruta and Keiko Mizuno and Nobuyuki Hara",

year = "1996",

month = nov,

day = "11",

doi = "10.1007/BF00123394",

language = "English",

volume = "14",

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journal = "Clinical and Experimental Metastasis",

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TY - JOUR

T1 - Granulocyte-colony stimulating factor promotes invasion by human lung cancer cell lines in vitro

AU - Pei, Xin Hai

AU - Nakanishi, Yoichi

AU - Takayama, Koichi

AU - Yatsunami, Jun

AU - Bai, Feng

AU - Kawasaki, Masayuki

AU - Wakamatsu, Kentaro

AU - Tsuruta, Nobuko

AU - Mizuno, Keiko

AU - Hara, Nobuyuki

PY - 1996/11/11

Y1 - 1996/11/11

N2 - The effects of exogenous and endogenous granulocyte colony-stimulating factor (G-CSF) on invasion by cancer cells were studied, using lung cancer cell lines that produce G-CSF (NCI-H157) and lines that do not (PC-9 and NCI-H23). The invasive capacity of NCI-H157 cells was 26- to 27-fold higher than that of PC-9 and NCI-H23 cells. The invasiveness of PC-9 cells was stimulated by exogenous G-CSF, while that of NCI-H157 cells was not. Antibodies against G-CSF blocked the stimulation of PC-9 cell invasiveness by exogenous G-CSF. Anti G-CSF antibodies also inhibited invasion by NCI-H157 cells in the absence of exogenous G-CSF. These results suggest that endogenous and exogenous G-CSF both stimulate invasion by lung cancer cells.

AB - The effects of exogenous and endogenous granulocyte colony-stimulating factor (G-CSF) on invasion by cancer cells were studied, using lung cancer cell lines that produce G-CSF (NCI-H157) and lines that do not (PC-9 and NCI-H23). The invasive capacity of NCI-H157 cells was 26- to 27-fold higher than that of PC-9 and NCI-H23 cells. The invasiveness of PC-9 cells was stimulated by exogenous G-CSF, while that of NCI-H157 cells was not. Antibodies against G-CSF blocked the stimulation of PC-9 cell invasiveness by exogenous G-CSF. Anti G-CSF antibodies also inhibited invasion by NCI-H157 cells in the absence of exogenous G-CSF. These results suggest that endogenous and exogenous G-CSF both stimulate invasion by lung cancer cells.

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U2 - 10.1007/BF00123394

DO - 10.1007/BF00123394

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JO - Clinical and Experimental Metastasis

JF - Clinical and Experimental Metastasis

IS - 4

ER -

Granulocyte-colony stimulating factor promotes invasion by human lung cancer cell lines in vitro

Abstract

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UN SDGs

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