Abstract
Summary. We studied the utility of G‐CSF for harvesting circulating haematopoietic stem cells in patients with leukaemia or lymphoma based on a comparative study in a single patient. Two successive cycles of leukapheresis following cytotoxic chemotherapy were performed in 22 patients as follows: the first cycle was performed with cytotoxic mobilization in all patients while the second cycle was randomized into two groups: cytotoxic (n= 10) and cytotoxic plus G‐CSF (cytotoxic/G‐CSF) (n= 12) mobilization. Repetitive cytotoxic mobilization did not alter the yields of mononuclear cells (MNC), myeloid (CFU‐GM), and erythroid (BFU‐E) progenitors. In contrast, cytotoxic/G‐CSF mobilization produced significantly higher yields of MNC (2·6‐fold), CFU‐GM (5·5‐fold), and BFU‐E (3·9‐fold) than did cytotoxic mobilization alone (P<0·01). The ratio of CFU‐GM to BFU‐E was not affected by G‐CSF. Furthermore, G‐CSF led to an earlier peak of CFU‐GM following chemotherapy. G‐CSF is thus effective in expanding the pool of circulating haematopoietic progenitors.
| Original language | English |
|---|---|
| Pages (from-to) | 570-573 |
| Number of pages | 4 |
| Journal | British Journal of Haematology |
| Volume | 84 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Aug 1993 |
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All Science Journal Classification (ASJC) codes
- Hematology
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Granulocyte colony‐stimulating factor (G‐CSF)‐induced mobilization of circulating haemopoietic stem cells. / Teshima, Takanori; Harada, Mine; Takamatsu, Yasushi; Makino, Kazuyoshi; Inaba, Shoichi; Akashi, Koichi; Kondo, Seiji; Tanaka, Takeshi; Ishii, Eiichi; Niho, Yoshiyuki.
In: British Journal of Haematology, Vol. 84, No. 4, 08.1993, p. 570-573.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Granulocyte colony‐stimulating factor (G‐CSF)‐induced mobilization of circulating haemopoietic stem cells
AU - Teshima, Takanori
AU - Harada, Mine
AU - Takamatsu, Yasushi
AU - Makino, Kazuyoshi
AU - Inaba, Shoichi
AU - Akashi, Koichi
AU - Kondo, Seiji
AU - Tanaka, Takeshi
AU - Ishii, Eiichi
AU - Niho, Yoshiyuki
PY - 1993/8
Y1 - 1993/8
N2 - Summary. We studied the utility of G‐CSF for harvesting circulating haematopoietic stem cells in patients with leukaemia or lymphoma based on a comparative study in a single patient. Two successive cycles of leukapheresis following cytotoxic chemotherapy were performed in 22 patients as follows: the first cycle was performed with cytotoxic mobilization in all patients while the second cycle was randomized into two groups: cytotoxic (n= 10) and cytotoxic plus G‐CSF (cytotoxic/G‐CSF) (n= 12) mobilization. Repetitive cytotoxic mobilization did not alter the yields of mononuclear cells (MNC), myeloid (CFU‐GM), and erythroid (BFU‐E) progenitors. In contrast, cytotoxic/G‐CSF mobilization produced significantly higher yields of MNC (2·6‐fold), CFU‐GM (5·5‐fold), and BFU‐E (3·9‐fold) than did cytotoxic mobilization alone (P<0·01). The ratio of CFU‐GM to BFU‐E was not affected by G‐CSF. Furthermore, G‐CSF led to an earlier peak of CFU‐GM following chemotherapy. G‐CSF is thus effective in expanding the pool of circulating haematopoietic progenitors.
AB - Summary. We studied the utility of G‐CSF for harvesting circulating haematopoietic stem cells in patients with leukaemia or lymphoma based on a comparative study in a single patient. Two successive cycles of leukapheresis following cytotoxic chemotherapy were performed in 22 patients as follows: the first cycle was performed with cytotoxic mobilization in all patients while the second cycle was randomized into two groups: cytotoxic (n= 10) and cytotoxic plus G‐CSF (cytotoxic/G‐CSF) (n= 12) mobilization. Repetitive cytotoxic mobilization did not alter the yields of mononuclear cells (MNC), myeloid (CFU‐GM), and erythroid (BFU‐E) progenitors. In contrast, cytotoxic/G‐CSF mobilization produced significantly higher yields of MNC (2·6‐fold), CFU‐GM (5·5‐fold), and BFU‐E (3·9‐fold) than did cytotoxic mobilization alone (P<0·01). The ratio of CFU‐GM to BFU‐E was not affected by G‐CSF. Furthermore, G‐CSF led to an earlier peak of CFU‐GM following chemotherapy. G‐CSF is thus effective in expanding the pool of circulating haematopoietic progenitors.
UR - http://www.scopus.com/inward/record.url?scp=0027284457&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027284457&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2141.1993.tb03129.x
DO - 10.1111/j.1365-2141.1993.tb03129.x
M3 - Article
C2 - 7692934
AN - SCOPUS:0027284457
VL - 84
SP - 570
EP - 573
JO - British Journal of Haematology
JF - British Journal of Haematology
SN - 0007-1048
IS - 4
ER -