Granulocyte colony‐stimulating factor (G‐CSF)‐induced mobilization of circulating haemopoietic stem cells

Takanori Teshima, Mine Harada, Yasushi Takamatsu, Kazuyoshi Makino, Shoichi Inaba, Koichi Akashi, Seiji Kondo, Takeshi Tanaka, Eiichi Ishii, Yoshiyuki Niho

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Abstract

Summary. We studied the utility of G‐CSF for harvesting circulating haematopoietic stem cells in patients with leukaemia or lymphoma based on a comparative study in a single patient. Two successive cycles of leukapheresis following cytotoxic chemotherapy were performed in 22 patients as follows: the first cycle was performed with cytotoxic mobilization in all patients while the second cycle was randomized into two groups: cytotoxic (n= 10) and cytotoxic plus G‐CSF (cytotoxic/G‐CSF) (n= 12) mobilization. Repetitive cytotoxic mobilization did not alter the yields of mononuclear cells (MNC), myeloid (CFU‐GM), and erythroid (BFU‐E) progenitors. In contrast, cytotoxic/G‐CSF mobilization produced significantly higher yields of MNC (2·6‐fold), CFU‐GM (5·5‐fold), and BFU‐E (3·9‐fold) than did cytotoxic mobilization alone (P<0·01). The ratio of CFU‐GM to BFU‐E was not affected by G‐CSF. Furthermore, G‐CSF led to an earlier peak of CFU‐GM following chemotherapy. G‐CSF is thus effective in expanding the pool of circulating haematopoietic progenitors.

Original languageEnglish
Pages (from-to)570-573
Number of pages4
JournalBritish Journal of Haematology
Volume84
Issue number4
DOIs
Publication statusPublished - Jan 1 1993

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Granulocyte-Macrophage Progenitor Cells
Granulocytes
Stem Cells
Leukapheresis
Drug Therapy
Erythroid Cells
Myeloid Cells
Hematopoietic Stem Cells
Lymphoma
Leukemia

All Science Journal Classification (ASJC) codes

  • Hematology

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Granulocyte colony‐stimulating factor (G‐CSF)‐induced mobilization of circulating haemopoietic stem cells. / Teshima, Takanori; Harada, Mine; Takamatsu, Yasushi; Makino, Kazuyoshi; Inaba, Shoichi; Akashi, Koichi; Kondo, Seiji; Tanaka, Takeshi; Ishii, Eiichi; Niho, Yoshiyuki.

In: British Journal of Haematology, Vol. 84, No. 4, 01.01.1993, p. 570-573.

Research output: Contribution to journalArticle

Teshima, T, Harada, M, Takamatsu, Y, Makino, K, Inaba, S, Akashi, K, Kondo, S, Tanaka, T, Ishii, E & Niho, Y 1993, 'Granulocyte colony‐stimulating factor (G‐CSF)‐induced mobilization of circulating haemopoietic stem cells', British Journal of Haematology, vol. 84, no. 4, pp. 570-573. https://doi.org/10.1111/j.1365-2141.1993.tb03129.x
Teshima, Takanori ; Harada, Mine ; Takamatsu, Yasushi ; Makino, Kazuyoshi ; Inaba, Shoichi ; Akashi, Koichi ; Kondo, Seiji ; Tanaka, Takeshi ; Ishii, Eiichi ; Niho, Yoshiyuki. / Granulocyte colony‐stimulating factor (G‐CSF)‐induced mobilization of circulating haemopoietic stem cells. In: British Journal of Haematology. 1993 ; Vol. 84, No. 4. pp. 570-573.
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