Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers

Jun Ichi Oyama, Toyoki Maeda, Kazuya Kouzuma, Ryuji Ochiai, Ichiro Tokimitsu, Yoshihiro Higuchi, Masahiro Sugano, Naoki Makino

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: Because green tea reduces cardiovascular and cerebrovascular risk, the purpose of this study aimed to elucidate the effect of green tea catechins (GTC) on endothelial dysfunction in smokers. Methods and Results: The 30 healthy male smokers were divided into 3 groups and given green tea beverages containing 0 mg (control group), 80 mg (medium-dose group) or 580 mg (high-dose group) of GTC daily for 2 weeks. Endothelial-dependent and- independent vasodilatation was investigated by measuring the forearm blood flow (FBF) responses to acetylcholine and sodium nitroprusside using venous occlusion strain-gauge plethysmography. The FBF response to acetylcholine significantly increased at 2 h and 1 and 2 weeks after GTC intake in the high-dose group, but no increase was observed in the other groups. FBF responses to sodium nitroprusside did not alter in any group at any time point. A significant increase in plasma nitric oxide and a decrease in asymmetrical dimethylarginine, malondealdehyde and 4-hydroxynonenal, C-reactive protein, monocyte chemotactic protein-1, and soluble CD40 ligand levels were detected after chronic consumption of high-dose GTC. Conclusions: GTC have antiatherosclerotic effects on dysfunctional vessels in smokers through increasing the level of nitric oxide and reducing oxidative stress.

Original languageEnglish
Pages (from-to)578-588
Number of pages11
JournalCirculation Journal
Volume74
Issue number3
DOIs
Publication statusPublished - Mar 1 2010

Fingerprint

Catechin
Tea
Forearm
Nitroprusside
Acetylcholine
Nitric Oxide
CD40 Ligand
Plethysmography
Chemokine CCL2
Beverages
Vasodilation
C-Reactive Protein
Oxidative Stress
Control Groups

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers. / Oyama, Jun Ichi; Maeda, Toyoki; Kouzuma, Kazuya; Ochiai, Ryuji; Tokimitsu, Ichiro; Higuchi, Yoshihiro; Sugano, Masahiro; Makino, Naoki.

In: Circulation Journal, Vol. 74, No. 3, 01.03.2010, p. 578-588.

Research output: Contribution to journalArticle

Oyama, Jun Ichi ; Maeda, Toyoki ; Kouzuma, Kazuya ; Ochiai, Ryuji ; Tokimitsu, Ichiro ; Higuchi, Yoshihiro ; Sugano, Masahiro ; Makino, Naoki. / Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers. In: Circulation Journal. 2010 ; Vol. 74, No. 3. pp. 578-588.
@article{62f59e0141f3465ab0fd50f47fa3d906,
title = "Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers",
abstract = "Background: Because green tea reduces cardiovascular and cerebrovascular risk, the purpose of this study aimed to elucidate the effect of green tea catechins (GTC) on endothelial dysfunction in smokers. Methods and Results: The 30 healthy male smokers were divided into 3 groups and given green tea beverages containing 0 mg (control group), 80 mg (medium-dose group) or 580 mg (high-dose group) of GTC daily for 2 weeks. Endothelial-dependent and- independent vasodilatation was investigated by measuring the forearm blood flow (FBF) responses to acetylcholine and sodium nitroprusside using venous occlusion strain-gauge plethysmography. The FBF response to acetylcholine significantly increased at 2 h and 1 and 2 weeks after GTC intake in the high-dose group, but no increase was observed in the other groups. FBF responses to sodium nitroprusside did not alter in any group at any time point. A significant increase in plasma nitric oxide and a decrease in asymmetrical dimethylarginine, malondealdehyde and 4-hydroxynonenal, C-reactive protein, monocyte chemotactic protein-1, and soluble CD40 ligand levels were detected after chronic consumption of high-dose GTC. Conclusions: GTC have antiatherosclerotic effects on dysfunctional vessels in smokers through increasing the level of nitric oxide and reducing oxidative stress.",
author = "Oyama, {Jun Ichi} and Toyoki Maeda and Kazuya Kouzuma and Ryuji Ochiai and Ichiro Tokimitsu and Yoshihiro Higuchi and Masahiro Sugano and Naoki Makino",
year = "2010",
month = "3",
day = "1",
doi = "10.1253/circj.CJ-09-0692",
language = "English",
volume = "74",
pages = "578--588",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "3",

}

TY - JOUR

T1 - Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers

AU - Oyama, Jun Ichi

AU - Maeda, Toyoki

AU - Kouzuma, Kazuya

AU - Ochiai, Ryuji

AU - Tokimitsu, Ichiro

AU - Higuchi, Yoshihiro

AU - Sugano, Masahiro

AU - Makino, Naoki

PY - 2010/3/1

Y1 - 2010/3/1

N2 - Background: Because green tea reduces cardiovascular and cerebrovascular risk, the purpose of this study aimed to elucidate the effect of green tea catechins (GTC) on endothelial dysfunction in smokers. Methods and Results: The 30 healthy male smokers were divided into 3 groups and given green tea beverages containing 0 mg (control group), 80 mg (medium-dose group) or 580 mg (high-dose group) of GTC daily for 2 weeks. Endothelial-dependent and- independent vasodilatation was investigated by measuring the forearm blood flow (FBF) responses to acetylcholine and sodium nitroprusside using venous occlusion strain-gauge plethysmography. The FBF response to acetylcholine significantly increased at 2 h and 1 and 2 weeks after GTC intake in the high-dose group, but no increase was observed in the other groups. FBF responses to sodium nitroprusside did not alter in any group at any time point. A significant increase in plasma nitric oxide and a decrease in asymmetrical dimethylarginine, malondealdehyde and 4-hydroxynonenal, C-reactive protein, monocyte chemotactic protein-1, and soluble CD40 ligand levels were detected after chronic consumption of high-dose GTC. Conclusions: GTC have antiatherosclerotic effects on dysfunctional vessels in smokers through increasing the level of nitric oxide and reducing oxidative stress.

AB - Background: Because green tea reduces cardiovascular and cerebrovascular risk, the purpose of this study aimed to elucidate the effect of green tea catechins (GTC) on endothelial dysfunction in smokers. Methods and Results: The 30 healthy male smokers were divided into 3 groups and given green tea beverages containing 0 mg (control group), 80 mg (medium-dose group) or 580 mg (high-dose group) of GTC daily for 2 weeks. Endothelial-dependent and- independent vasodilatation was investigated by measuring the forearm blood flow (FBF) responses to acetylcholine and sodium nitroprusside using venous occlusion strain-gauge plethysmography. The FBF response to acetylcholine significantly increased at 2 h and 1 and 2 weeks after GTC intake in the high-dose group, but no increase was observed in the other groups. FBF responses to sodium nitroprusside did not alter in any group at any time point. A significant increase in plasma nitric oxide and a decrease in asymmetrical dimethylarginine, malondealdehyde and 4-hydroxynonenal, C-reactive protein, monocyte chemotactic protein-1, and soluble CD40 ligand levels were detected after chronic consumption of high-dose GTC. Conclusions: GTC have antiatherosclerotic effects on dysfunctional vessels in smokers through increasing the level of nitric oxide and reducing oxidative stress.

UR - http://www.scopus.com/inward/record.url?scp=77649205819&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77649205819&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-09-0692

DO - 10.1253/circj.CJ-09-0692

M3 - Article

C2 - 20134098

AN - SCOPUS:77649205819

VL - 74

SP - 578

EP - 588

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 3

ER -