Green tea component, (-)-epigallocatechin gallate, but not L-theanine, has sedative effects in chick under acute stress conditions

Nami Adachi, Yang Ho Choi, Rie Suenaga, Shozo Tomonaga, D. Michael Denbow, Mitsuhiro Furuse

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Tea has two major components that may act on the brain to reduce stress. One is (-)-epigallocatechin gallate (EGCG), which we have recently shown to cause a sedative effect through gamma-aminobutyric acid (GABA) A receptors in the brain of neonatal chicks, and another is L-theanine that is shown to induce a feeling of relaxation in humans. The purpose of the present study was to compare the effects of EGCG and theanine on stress in neonatal chicks. Intracerebroventricular (i.c.v.) injection of EGCG (109 nmol) attenuated the increase in vocalization and spontaneous activity that is observed during a 10 min social-isolation stress. Consistent with this result, EGCG decreased the time for active wakefulness while increasing that of sleep-like behavior. L-Theanine (109 nmol) had no effect on these behaviors. It was concluded that central EGCG, but not L-theanine, plays a role in reducing stress associated with social isolation in our model using neonatal chicks.

Original languageEnglish
Pages (from-to)107-110
Number of pages4
JournalCurrent Topics in Nutraceutical Research
Volume5
Issue number2-3
Publication statusPublished - May 1 2007

Fingerprint

Tea
Hypnotics and Sedatives
Social Isolation
GABA Receptors
Wakefulness
Brain
Sleep
Emotions
epigallocatechin gallate
theanine
Injections

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Green tea component, (-)-epigallocatechin gallate, but not L-theanine, has sedative effects in chick under acute stress conditions. / Adachi, Nami; Choi, Yang Ho; Suenaga, Rie; Tomonaga, Shozo; Denbow, D. Michael; Furuse, Mitsuhiro.

In: Current Topics in Nutraceutical Research, Vol. 5, No. 2-3, 01.05.2007, p. 107-110.

Research output: Contribution to journalArticle

Adachi, Nami ; Choi, Yang Ho ; Suenaga, Rie ; Tomonaga, Shozo ; Denbow, D. Michael ; Furuse, Mitsuhiro. / Green tea component, (-)-epigallocatechin gallate, but not L-theanine, has sedative effects in chick under acute stress conditions. In: Current Topics in Nutraceutical Research. 2007 ; Vol. 5, No. 2-3. pp. 107-110.
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