Abstract
Tea has two major components that may act on the brain to reduce stress. One is (-)-epigallocatechin gallate (EGCG), which we have recently shown to cause a sedative effect through gamma-aminobutyric acid (GABA) A receptors in the brain of neonatal chicks, and another is L-theanine that is shown to induce a feeling of relaxation in humans. The purpose of the present study was to compare the effects of EGCG and theanine on stress in neonatal chicks. Intracerebroventricular (i.c.v.) injection of EGCG (109 nmol) attenuated the increase in vocalization and spontaneous activity that is observed during a 10 min social-isolation stress. Consistent with this result, EGCG decreased the time for active wakefulness while increasing that of sleep-like behavior. L-Theanine (109 nmol) had no effect on these behaviors. It was concluded that central EGCG, but not L-theanine, plays a role in reducing stress associated with social isolation in our model using neonatal chicks.
| Original language | English |
|---|---|
| Pages (from-to) | 107-110 |
| Number of pages | 4 |
| Journal | Current Topics in Nutraceutical Research |
| Volume | 5 |
| Issue number | 2-3 |
| Publication status | Published - May 1 2007 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Green tea component, (-)-epigallocatechin gallate, but not L-theanine, has sedative effects in chick under acute stress conditions. / Adachi, Nami; Choi, Yang Ho; Suenaga, Rie; Tomonaga, Shozo; Denbow, D. Michael; Furuse, Mitsuhiro.
In: Current Topics in Nutraceutical Research, Vol. 5, No. 2-3, 01.05.2007, p. 107-110.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Green tea component, (-)-epigallocatechin gallate, but not L-theanine, has sedative effects in chick under acute stress conditions
AU - Adachi, Nami
AU - Choi, Yang Ho
AU - Suenaga, Rie
AU - Tomonaga, Shozo
AU - Denbow, D. Michael
AU - Furuse, Mitsuhiro
PY - 2007/5/1
Y1 - 2007/5/1
N2 - Tea has two major components that may act on the brain to reduce stress. One is (-)-epigallocatechin gallate (EGCG), which we have recently shown to cause a sedative effect through gamma-aminobutyric acid (GABA) A receptors in the brain of neonatal chicks, and another is L-theanine that is shown to induce a feeling of relaxation in humans. The purpose of the present study was to compare the effects of EGCG and theanine on stress in neonatal chicks. Intracerebroventricular (i.c.v.) injection of EGCG (109 nmol) attenuated the increase in vocalization and spontaneous activity that is observed during a 10 min social-isolation stress. Consistent with this result, EGCG decreased the time for active wakefulness while increasing that of sleep-like behavior. L-Theanine (109 nmol) had no effect on these behaviors. It was concluded that central EGCG, but not L-theanine, plays a role in reducing stress associated with social isolation in our model using neonatal chicks.
AB - Tea has two major components that may act on the brain to reduce stress. One is (-)-epigallocatechin gallate (EGCG), which we have recently shown to cause a sedative effect through gamma-aminobutyric acid (GABA) A receptors in the brain of neonatal chicks, and another is L-theanine that is shown to induce a feeling of relaxation in humans. The purpose of the present study was to compare the effects of EGCG and theanine on stress in neonatal chicks. Intracerebroventricular (i.c.v.) injection of EGCG (109 nmol) attenuated the increase in vocalization and spontaneous activity that is observed during a 10 min social-isolation stress. Consistent with this result, EGCG decreased the time for active wakefulness while increasing that of sleep-like behavior. L-Theanine (109 nmol) had no effect on these behaviors. It was concluded that central EGCG, but not L-theanine, plays a role in reducing stress associated with social isolation in our model using neonatal chicks.
UR - http://www.scopus.com/inward/record.url?scp=37849036998&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=37849036998&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:37849036998
VL - 5
SP - 107
EP - 110
JO - Current Topics in Nutraceutical Research
JF - Current Topics in Nutraceutical Research
SN - 1540-7535
IS - 2-3
ER -