Green tea polyphenol sensing

Research output: Contribution to journalReview article

59 Citations (Scopus)

Abstract

Green tea polyphenols have emerged over the past two decades as an important dietary factor for health promotion. There is considerable evidence that tea polyphenols, in particular (-)-epigallocatechin-3-gallate (EGCG) inhibit carcinogenesis. However, the mechanisms for the cancer-preventive activity of EGCG are not completely characterized and many features remain to be elucidated. Recently we have identified a cell-surface EGCG receptor and the relating molecules that confer EGCG responsiveness to many cancer cells at physiological concentrations. Here, we review some of the reported mechanisms for the cancer chemopreventive action of EGCG and provide an overview of several molecules that sense and manage the physiological functions of EGCG.

Original languageEnglish
Pages (from-to)66-80
Number of pages15
JournalProceedings of the Japan Academy Series B: Physical and Biological Sciences
Volume87
Issue number3
DOIs
Publication statusPublished - Apr 4 2011

Fingerprint

gallates
epigallocatechin
Polyphenols
green tea
Tea
polyphenols
cancer
Neoplasms
health promotion
neoplasms
promotion
Health Promotion
carcinogenesis
tea
health
epigallocatechin gallate
molecules
Carcinogenesis
receptors
cells

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Physics and Astronomy(all)

Cite this

Green tea polyphenol sensing. / Tachibana, Hirofumi.

In: Proceedings of the Japan Academy Series B: Physical and Biological Sciences, Vol. 87, No. 3, 04.04.2011, p. 66-80.

Research output: Contribution to journalReview article

@article{b044ab614cb349f3b217f3d87bd5eb2b,
title = "Green tea polyphenol sensing",
abstract = "Green tea polyphenols have emerged over the past two decades as an important dietary factor for health promotion. There is considerable evidence that tea polyphenols, in particular (-)-epigallocatechin-3-gallate (EGCG) inhibit carcinogenesis. However, the mechanisms for the cancer-preventive activity of EGCG are not completely characterized and many features remain to be elucidated. Recently we have identified a cell-surface EGCG receptor and the relating molecules that confer EGCG responsiveness to many cancer cells at physiological concentrations. Here, we review some of the reported mechanisms for the cancer chemopreventive action of EGCG and provide an overview of several molecules that sense and manage the physiological functions of EGCG.",
author = "Hirofumi Tachibana",
year = "2011",
month = "4",
day = "4",
doi = "10.2183/pjab.87.66",
language = "English",
volume = "87",
pages = "66--80",
journal = "Proceedings of the Japan Academy Series B: Physical and Biological Sciences",
issn = "0386-2208",
publisher = "Japan Academy",
number = "3",

}

TY - JOUR

T1 - Green tea polyphenol sensing

AU - Tachibana, Hirofumi

PY - 2011/4/4

Y1 - 2011/4/4

N2 - Green tea polyphenols have emerged over the past two decades as an important dietary factor for health promotion. There is considerable evidence that tea polyphenols, in particular (-)-epigallocatechin-3-gallate (EGCG) inhibit carcinogenesis. However, the mechanisms for the cancer-preventive activity of EGCG are not completely characterized and many features remain to be elucidated. Recently we have identified a cell-surface EGCG receptor and the relating molecules that confer EGCG responsiveness to many cancer cells at physiological concentrations. Here, we review some of the reported mechanisms for the cancer chemopreventive action of EGCG and provide an overview of several molecules that sense and manage the physiological functions of EGCG.

AB - Green tea polyphenols have emerged over the past two decades as an important dietary factor for health promotion. There is considerable evidence that tea polyphenols, in particular (-)-epigallocatechin-3-gallate (EGCG) inhibit carcinogenesis. However, the mechanisms for the cancer-preventive activity of EGCG are not completely characterized and many features remain to be elucidated. Recently we have identified a cell-surface EGCG receptor and the relating molecules that confer EGCG responsiveness to many cancer cells at physiological concentrations. Here, we review some of the reported mechanisms for the cancer chemopreventive action of EGCG and provide an overview of several molecules that sense and manage the physiological functions of EGCG.

UR - http://www.scopus.com/inward/record.url?scp=79953180083&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953180083&partnerID=8YFLogxK

U2 - 10.2183/pjab.87.66

DO - 10.2183/pjab.87.66

M3 - Review article

C2 - 21422740

AN - SCOPUS:79953180083

VL - 87

SP - 66

EP - 80

JO - Proceedings of the Japan Academy Series B: Physical and Biological Sciences

JF - Proceedings of the Japan Academy Series B: Physical and Biological Sciences

SN - 0386-2208

IS - 3

ER -