Grouping of 20 reference strains of Legionella species by the growth ability within mouse and guinea pig macrophages

Kunio Izu, Shin Ichi Yoshida, Hiroshi Miyamoto, Bin Chang, Midori Ogawa, Hiroyuki Yamamoto, Yoshitaka Goto, Hatsumi Taniguchi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

20 Reference strains of Legionella species, isolated from human, were classified according to their ability to grow within thioglycolate-induced peritoneal macrophages of mice and guinea pigs. Inbred and congenic mice were used to study the effect of the natural resistance genes Lgn1 and Bcg that are expressed phenotypically in the mouse macrophages. The Lgn1 gene controlled the intracellular growth of Legionella pneumophila Philadelphia-1 and Legionella jordanis GIFU 12657, but the Bcg gene did not affect the intracellular growth of any organism examined. Based on these results and the growth ability in guinea pig macrophages, the 20 reference strains were divided into four groups. This grouping will help us to understand a variety of modes of interaction between Legionella species and macrophages.

Original languageEnglish
Pages (from-to)61-68
Number of pages8
JournalFEMS Immunology and Medical Microbiology
Volume26
Issue number1
DOIs
Publication statusPublished - Oct 1 1999
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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