Growth-associated gene expression profiles by microarray analysis of trophoblast of molar pregnancies and normal villi

H. D. Kato, Y. Terao, M. Ogawa, T. Matsuda, T. Arima, Kiyoko Kato, Z. Yong, N. Wake

    Research output: Contribution to journalArticlepeer-review

    28 Citations (Scopus)

    Abstract

    We used microarray analysis to investigate expression profiles of 589 known genes committed to cell growth control to characterize regulatory circuitry for cell proliferation in complete moles (CMs). CMs are characterized by hyperplastic trophoblast and have a high propensity to give rise to choriocarcinoma. Characteristic alterations in gene expression profiles were observed when compared with normal villi. Fifty-seven genes were significantly up-regulated in CMs and involved the Ras-Map kinase 3, Jak-STAT5, and Wnt signal pathways, implicating growth factor or cytokine-mediated signal pathways in the trophoblastic hyperplasia of CMs. Several genes associated with anti-apoptosis, cell structuring, and/or cell attachment were also up-regulated in CMs. In contrast, relatively fewer genes were down-regulated and these involved IGFBPs, versican, interleukin-1, tumor necrosis factor receptor, CD44, and RAD52. Genes identified in this study may elucidate regulation mechanisms of trophoblastic proliferation and mechanisms causing a pathological phenotype in CMs.

    Original languageEnglish
    Pages (from-to)255-260
    Number of pages6
    JournalInternational Journal of Gynecological Pathology
    Volume21
    Issue number3
    DOIs
    Publication statusPublished - Jan 1 2002

    All Science Journal Classification (ASJC) codes

    • Pathology and Forensic Medicine
    • Obstetrics and Gynaecology

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