Growth inhibition of human salivary gland tumor cells by introduction of progesterone (Pg) receptor and Pg treatment

T. Yoshimura, Tomoki Sumida, S. Liu, A. Onishi, S. Shintani, P. Y. Desprez, H. Hamakawa

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Cancer of the salivary gland is one of the common cancers in the head and the neck regions. This type of cancer develops in the minor and the major salivary glands, and it sometimes metastasizes to other organs, particularly the lung. Morphologic mimicry and similarity in the expression of steroid hormone receptors between salivary gland tumors (SGTs) and breast tumors are well-known phenomena and are occasionally debated in the field of surgical pathology. Progesterone (Pg), one of the female sex steroid hormone, is intimately involved in the development of the mammary gland. Further, it is believed that Pg plays a role in breast cancer progression. However, little is known regarding its role in SGTs. In this study, we used ACCM, a human adenoid cystic carcinoma cell line established from the salivary gland, in order to clarify the role of the Pg receptor (PR) on cell proliferation. No effect of Pg on cell proliferation was observed in the PR-deficient aggressive ACCM cells. However, after introducing PR into the ACCM cells, Pg markedly inhibited the proliferative activity of the cells. This inhibitory effect on cell proliferation was accompanied by p21 upregulation, and Id1 and c-myc downregulation. Moreover, Pg-treated PR transfectants showed significant morphological change; they appeared more flattened and spread out when compared with the ethanol-treated control cells. Our results provided significant insights into the mechanism of suppression of the proliferative property of the cells via the function of PR, and suggested that PR reintroduction therapy might be a viable method of inhibiting human SGT progression.

Original languageEnglish
Pages (from-to)1107-1116
Number of pages10
JournalEndocrine-Related Cancer
Volume14
Issue number4
DOIs
Publication statusPublished - Dec 1 2007
Externally publishedYes

Fingerprint

Glandular and Epithelial Neoplasms
Progesterone Receptors
Progesterone
Growth
Cell Proliferation
Salivary Gland Neoplasms
Breast Neoplasms
Minor Salivary Glands
Adenoid Cystic Carcinoma
Surgical Pathology
Steroid Receptors
Gonadal Steroid Hormones
Human Mammary Glands
Head and Neck Neoplasms
Salivary Glands
Ethanol
Up-Regulation
Down-Regulation
Hormones
Cell Line

All Science Journal Classification (ASJC) codes

  • Endocrinology
  • Oncology
  • Cancer Research
  • Endocrinology, Diabetes and Metabolism

Cite this

Growth inhibition of human salivary gland tumor cells by introduction of progesterone (Pg) receptor and Pg treatment. / Yoshimura, T.; Sumida, Tomoki; Liu, S.; Onishi, A.; Shintani, S.; Desprez, P. Y.; Hamakawa, H.

In: Endocrine-Related Cancer, Vol. 14, No. 4, 01.12.2007, p. 1107-1116.

Research output: Contribution to journalArticle

Yoshimura, T. ; Sumida, Tomoki ; Liu, S. ; Onishi, A. ; Shintani, S. ; Desprez, P. Y. ; Hamakawa, H. / Growth inhibition of human salivary gland tumor cells by introduction of progesterone (Pg) receptor and Pg treatment. In: Endocrine-Related Cancer. 2007 ; Vol. 14, No. 4. pp. 1107-1116.
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