Growth patterns and prognosis of submucosal carcinoma of the esophagus. A pathologic study

Sinji Ohno, Masaki Mori, Shinichi Tsutsui, Hiroshi Matsuura, Hiroyuki Kuwano, Keizo Sugimachi, Kazuhiko Soejima

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Sixteen cases of esophageal carcinoma invading the submucosa were analyzed in terms of growth patterns. Seven were classified into the massively penetrating (down growth) type, four into the superficially spreading (spreading growth) type, and five into the unclassified type. In the down growth type, the ratio of the submucosal area to the total (mucosa and submucosa) area was more than 0.2 (one fifth), and in the others that ratio was less than 0.2. The down growth type is characterized by a tendency toward elevated lesions, a high incidence of vessel invasions and lymph node metastasis, and a poor prognosis after surgery. Lymphatic and/or vascular invasions were recognized in six of seven cases, and the 5‐year survival rate was 0%. In contrast, the spreading growth and unclassified types was characterized by superficial lesions, a low incidence of vessel invasions and lymph node metastasis, and a favorable prognosis. In only one with the spreading growth type was there lymphatic invasion. Three of the four with the spreading growth type survived over 5 years, and the other one with the spreading growth type and all of five with the unclassified type are alive without recurrences 15 to 52 months after surgery. Thus, growth patterns reflect well the prognosis of the submucosal carcinoma of the esophagus.

Original languageEnglish
Pages (from-to)335-340
Number of pages6
JournalCancer
Volume68
Issue number2
DOIs
Publication statusPublished - Jul 15 1991

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Esophagus
Carcinoma
Growth
Lymph Nodes
Neoplasm Metastasis
Incidence
Blood Vessels
Mucous Membrane
Recurrence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Growth patterns and prognosis of submucosal carcinoma of the esophagus. A pathologic study. / Ohno, Sinji; Mori, Masaki; Tsutsui, Shinichi; Matsuura, Hiroshi; Kuwano, Hiroyuki; Sugimachi, Keizo; Soejima, Kazuhiko.

In: Cancer, Vol. 68, No. 2, 15.07.1991, p. 335-340.

Research output: Contribution to journalArticle

Ohno, Sinji ; Mori, Masaki ; Tsutsui, Shinichi ; Matsuura, Hiroshi ; Kuwano, Hiroyuki ; Sugimachi, Keizo ; Soejima, Kazuhiko. / Growth patterns and prognosis of submucosal carcinoma of the esophagus. A pathologic study. In: Cancer. 1991 ; Vol. 68, No. 2. pp. 335-340.
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