GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture

Nana Matoba, Masato Akiyama, Kazuyoshi Ishigaki, Masahiro Kanai, Atsushi Takahashi, Yukihide Momozawa, Shiro Ikegawa, Masashi Ikeda, Nakao Iwata, Makoto Hirata, Koichi Matsuda, Michiaki Kubo, Yukinori Okada, Yoichiro Kamatani

Research output: Contribution to journalLetter

1 Citation (Scopus)

Abstract

Cigarette smoking is a risk factor for a wide range of human diseases 1 . To investigate the genetic components associated with smoking behaviours in the Japanese population, we conducted a genome-wide association study of four smoking-related traits using up to 165,436 individuals. In total, we identified seven new loci, including three loci associated with the number of cigarettes per day (EPHX2–CLU, RET and CUX2–ALDH2), three loci associated with smoking initiation (DLC1, CXCL12–TMEM72-AS1 and GALR1–SALL3) and LINC01793–MIR4432HG, associated with the age of smoking initiation. Of these, three loci (LINC01793–MIR4432HG, CXCL12–TMEM72-AS1 and GALR1–SALL3) were found by conducting an additional sex-stratified genome-wide association study. This additional analysis showed heterogeneity of effects between sexes. The cross-sex linkage disequilibrium score regression 2,3 analysis also indicated that the genetic component of smoking initiation was significantly different between the sexes. Cross-trait linkage disequilibrium score regression analysis and trait-relevant tissue analysis showed that the number of cigarettes per day has a specific genetic background distinct from those of the other three smoking behaviours. We also report 11 diseases that share genetic basis with smoking behaviours. Although the current study should be carefully considered owing to the lack of replication samples, our findings characterized the genetic architecture of smoking behaviours. Further studies in East Asian populations are warranted to confirm our findings.

Original languageEnglish
Pages (from-to)471-477
Number of pages7
JournalNature Human Behaviour
Volume3
Issue number5
DOIs
Publication statusPublished - May 1 2019

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Genetic Loci
Genome-Wide Association Study
Smoking
Linkage Disequilibrium
Tobacco Products
Inborn Genetic Diseases
Population
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Social Psychology
  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture. / Matoba, Nana; Akiyama, Masato; Ishigaki, Kazuyoshi; Kanai, Masahiro; Takahashi, Atsushi; Momozawa, Yukihide; Ikegawa, Shiro; Ikeda, Masashi; Iwata, Nakao; Hirata, Makoto; Matsuda, Koichi; Kubo, Michiaki; Okada, Yukinori; Kamatani, Yoichiro.

In: Nature Human Behaviour, Vol. 3, No. 5, 01.05.2019, p. 471-477.

Research output: Contribution to journalLetter

Matoba, N, Akiyama, M, Ishigaki, K, Kanai, M, Takahashi, A, Momozawa, Y, Ikegawa, S, Ikeda, M, Iwata, N, Hirata, M, Matsuda, K, Kubo, M, Okada, Y & Kamatani, Y 2019, 'GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture', Nature Human Behaviour, vol. 3, no. 5, pp. 471-477. https://doi.org/10.1038/s41562-019-0557-y
Matoba, Nana ; Akiyama, Masato ; Ishigaki, Kazuyoshi ; Kanai, Masahiro ; Takahashi, Atsushi ; Momozawa, Yukihide ; Ikegawa, Shiro ; Ikeda, Masashi ; Iwata, Nakao ; Hirata, Makoto ; Matsuda, Koichi ; Kubo, Michiaki ; Okada, Yukinori ; Kamatani, Yoichiro. / GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture. In: Nature Human Behaviour. 2019 ; Vol. 3, No. 5. pp. 471-477.
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AU - Takahashi, Atsushi

AU - Momozawa, Yukihide

AU - Ikegawa, Shiro

AU - Ikeda, Masashi

AU - Iwata, Nakao

AU - Hirata, Makoto

AU - Matsuda, Koichi

AU - Kubo, Michiaki

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