TY - JOUR
T1 - Gynecomastia associated with low-dose methotrexate therapy for rheumatoid arthritis ameliorated by folate supplement
AU - Fukushi, Jun Ichi
AU - Nakashima, Yasuharu
AU - Iwamoto, Yukihide
PY - 2010/8
Y1 - 2010/8
N2 - A 62-year-old male with a 10-year history of seropositive rheumatoid arthritis (RA) developed gynecomastia 8 months after beginning oral low-dose methotrexate (MTX) therapy. Two months after folate supplementation, the gynecomastia symptoms improved. Gynecomastia associated with low-dose MTX is a rare occurrence, with only nine cases previously reported in the literature. This is the first report showing folate supplementation to be effective against gynecomastia following low-dose MTX. Although it occurs infrequently, gynecomastia associated with low-dose MTX therapy should be considered in male patients with RA.
AB - A 62-year-old male with a 10-year history of seropositive rheumatoid arthritis (RA) developed gynecomastia 8 months after beginning oral low-dose methotrexate (MTX) therapy. Two months after folate supplementation, the gynecomastia symptoms improved. Gynecomastia associated with low-dose MTX is a rare occurrence, with only nine cases previously reported in the literature. This is the first report showing folate supplementation to be effective against gynecomastia following low-dose MTX. Although it occurs infrequently, gynecomastia associated with low-dose MTX therapy should be considered in male patients with RA.
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U2 - 10.1007/s00296-009-1062-9
DO - 10.1007/s00296-009-1062-9
M3 - Article
C2 - 19597731
AN - SCOPUS:77955549922
SN - 0172-8172
VL - 30
SP - 1371
EP - 1372
JO - Rheumatology International
JF - Rheumatology International
IS - 10
ER -