H-ras mutation is an additional event of sarcomatous transformation in aerodigestive spindle cell carcinoma

Hideki Shiratsuchi, Naoya Hirakawa, Tsuyoshi Saito, Yoshinao Oda, Hidetaka Yamamoto, Kichinobu Tomita, Tomoya Yamamoto, Masazumi Tsuneyoshi

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Abstract

The conversion from a carcinomatous component to a sarcomatous one in spindle cell carcinoma (SPCC) of the upper aerodigestive tract is thought to occur via a series of molecular alterations; however the detailed mechanism is still unknown. We examined mutations at the H-ras and p53 genes in 16 SPCCs of upper aerodigestive tracts using PCR-RFLP, PCR-SSCP and direct sequencing analysis. The two distinct components, sarcomatous and carcinomatous components in SPCC, were analyzed independently. p53 mutations were detected in both components of SPCC (50.0%, 8/16), and those in the sarcomatous component were completely in accordance with those in the carcinomatous one. In contrast, H-ras mutations were detected only in the sarcomatous component (12.5%, 2/16), and not in the carcinomatous one (0%, 0/16). There was a statistically significant difference in prognosis between the patients with the H-ras mutation (n=2) and those without (n=14); the former had poorer prognosis (P=0.0049). Our results seem to suggest that the H-ras mutation is a relatively uncommon event in SPCC; however, the presence of H-ras mutations may be associated with a more malignant potential in SPCC, while actually occurring during the sarcomatous change itself.

Original languageEnglish
Pages (from-to)597-604
Number of pages8
JournalOncology reports
Volume11
Issue number3
Publication statusPublished - Mar 1 2004

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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    Shiratsuchi, H., Hirakawa, N., Saito, T., Oda, Y., Yamamoto, H., Tomita, K., Yamamoto, T., & Tsuneyoshi, M. (2004). H-ras mutation is an additional event of sarcomatous transformation in aerodigestive spindle cell carcinoma. Oncology reports, 11(3), 597-604.