Haplotyping analyses on disease susceptibility genes in urogenital cancer: The application for ordermade care

A. Yokomizo, H. Koga, M. Nakashima, S. Naito, H. Noma, A. Yamaguchi

Research output: Contribution to journalArticle

Abstract

Variations in cancer-causative genes are potentially associated with high-risk groups of the disease. We hypothesized that Luteinizing hormone β, CYP17, Glutathione S-transferase (GST) P1, M1, T1 and insulin-like growth factor 1 receptor (IGF1R) are prostate cancer susceptibility molecules. We determined the distributions of polymorphisms in these genes in Caucasian familial prostate cancer patients (n=171), an age- and race-matched control group (n=144) and in Japanese prostate cancer patients (n=68), and a matched control group (n=126). We observed a significantly higher frequency of variant type of LHβ only in Caucasians, and not in Japanese. Furthermore, we found a significantly higher frequency of polymorphic valine105 in the GSTP1 gene both in Caucasians and in Japanese. Our results indicate that the genetic variants of LHβ and GSTP1 have some significance in the predisposition of prostate cancer in each population, and that these markers could be useful for predicting the prostate cancer risk of individuals.

Original languageEnglish
Pages (from-to)309-313
Number of pages5
JournalNishinihon Journal of Urology
Volume63
Issue number5
Publication statusPublished - Jan 1 2001

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Yokomizo, A., Koga, H., Nakashima, M., Naito, S., Noma, H., & Yamaguchi, A. (2001). Haplotyping analyses on disease susceptibility genes in urogenital cancer: The application for ordermade care. Nishinihon Journal of Urology, 63(5), 309-313.