Haptoglobin therapy for acute favism

A Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara

Shoichi Ohga, E. Higashi, A. Nomura, A. Matsuzaki, A. Hirono, S. Miwa, H. Fujii, K. Ueda

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We report the case of a 2-year-old Japanese boy with acute favism who was treated with human haptoglobin products. He had been exhibiting chronic nonspherocytic haemolytic anaemia until the diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency when 14 months old. He suffered a favic crisis at 24 months of age, when the administration of haptoglobin was effective for relieving bilirubinaemia and haemoglobinuria. Serum-free Hb rapidly decreased to normal levels despite the sustained level of serum lactate dehydrogenase. His G6PD gene was G6PD Guadalajara. This is the first application of haptoglobin therapy for acute favism and the first reported case of Japanese G6PD deficiency with typical favic crisis. Haptoglobin treatment might be helpful for managing the haemolytic crisis in the disease.

Original languageEnglish
Pages (from-to)421-423
Number of pages3
JournalBritish Journal of Haematology
Volume89
Issue number2
DOIs
Publication statusPublished - Jan 1 1995

Fingerprint

Favism
Haptoglobins
Glucosephosphate Dehydrogenase
Glucosephosphate Dehydrogenase Deficiency
His-His-His-His-His-His
Hemoglobinuria
Hyperbilirubinemia
Hemolytic Anemia
Serum
L-Lactate Dehydrogenase
Therapeutics
Genes

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Haptoglobin therapy for acute favism : A Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara. / Ohga, Shoichi; Higashi, E.; Nomura, A.; Matsuzaki, A.; Hirono, A.; Miwa, S.; Fujii, H.; Ueda, K.

In: British Journal of Haematology, Vol. 89, No. 2, 01.01.1995, p. 421-423.

Research output: Contribution to journalArticle

Ohga, Shoichi ; Higashi, E. ; Nomura, A. ; Matsuzaki, A. ; Hirono, A. ; Miwa, S. ; Fujii, H. ; Ueda, K. / Haptoglobin therapy for acute favism : A Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara. In: British Journal of Haematology. 1995 ; Vol. 89, No. 2. pp. 421-423.
@article{d8f5476950ab4d3cac02994d715b461d,
title = "Haptoglobin therapy for acute favism: A Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara",
abstract = "We report the case of a 2-year-old Japanese boy with acute favism who was treated with human haptoglobin products. He had been exhibiting chronic nonspherocytic haemolytic anaemia until the diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency when 14 months old. He suffered a favic crisis at 24 months of age, when the administration of haptoglobin was effective for relieving bilirubinaemia and haemoglobinuria. Serum-free Hb rapidly decreased to normal levels despite the sustained level of serum lactate dehydrogenase. His G6PD gene was G6PD Guadalajara. This is the first application of haptoglobin therapy for acute favism and the first reported case of Japanese G6PD deficiency with typical favic crisis. Haptoglobin treatment might be helpful for managing the haemolytic crisis in the disease.",
author = "Shoichi Ohga and E. Higashi and A. Nomura and A. Matsuzaki and A. Hirono and S. Miwa and H. Fujii and K. Ueda",
year = "1995",
month = "1",
day = "1",
doi = "10.1111/j.1365-2141.1995.tb03322.x",
language = "English",
volume = "89",
pages = "421--423",
journal = "British Journal of Haematology",
issn = "0007-1048",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Haptoglobin therapy for acute favism

T2 - A Japanese boy with glucose-6-phosphate dehydrogenase Guadalajara

AU - Ohga, Shoichi

AU - Higashi, E.

AU - Nomura, A.

AU - Matsuzaki, A.

AU - Hirono, A.

AU - Miwa, S.

AU - Fujii, H.

AU - Ueda, K.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - We report the case of a 2-year-old Japanese boy with acute favism who was treated with human haptoglobin products. He had been exhibiting chronic nonspherocytic haemolytic anaemia until the diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency when 14 months old. He suffered a favic crisis at 24 months of age, when the administration of haptoglobin was effective for relieving bilirubinaemia and haemoglobinuria. Serum-free Hb rapidly decreased to normal levels despite the sustained level of serum lactate dehydrogenase. His G6PD gene was G6PD Guadalajara. This is the first application of haptoglobin therapy for acute favism and the first reported case of Japanese G6PD deficiency with typical favic crisis. Haptoglobin treatment might be helpful for managing the haemolytic crisis in the disease.

AB - We report the case of a 2-year-old Japanese boy with acute favism who was treated with human haptoglobin products. He had been exhibiting chronic nonspherocytic haemolytic anaemia until the diagnosis of glucose-6-phosphate dehydrogenase (G6PD) deficiency when 14 months old. He suffered a favic crisis at 24 months of age, when the administration of haptoglobin was effective for relieving bilirubinaemia and haemoglobinuria. Serum-free Hb rapidly decreased to normal levels despite the sustained level of serum lactate dehydrogenase. His G6PD gene was G6PD Guadalajara. This is the first application of haptoglobin therapy for acute favism and the first reported case of Japanese G6PD deficiency with typical favic crisis. Haptoglobin treatment might be helpful for managing the haemolytic crisis in the disease.

UR - http://www.scopus.com/inward/record.url?scp=0028962122&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028962122&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2141.1995.tb03322.x

DO - 10.1111/j.1365-2141.1995.tb03322.x

M3 - Article

VL - 89

SP - 421

EP - 423

JO - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 2

ER -