Harmonization of Standardized Uptake Value among Different Generation PET/ CT Cameras Based on a Phantom Experiment -Utility of SUV(peak)

Go Akamatsu, Hiroyuki Nishida, Akira Fujino, Akihito Ohnishi, Yasuhiko Ikari, Tomoyuki Nishio, Akira Maebatake, Masayuki Sasaki, Michio Senda

Research output: Contribution to journalArticle

Abstract

Standardized uptake value (SUV) has been widely used as a semi-quantitative metric of uptake in FDGPET/ CT for diagnosis of malignant tumors and evaluation of tumor therapies. However, the SUV depends on various factors including PET/CT scanner specifications and reconstruction parameters. The purpose of this study is to harmonize the SUV among two PET/CT models of different generation: two units of Discovery ST Elite Performance(DSTEP) and Discovery 690 (D690) PET/CT scanners. The NEMA body phantom filled with 18F solution was scanned for 30 minutes in list-mode. The D690 PET images were reconstructed with OSEM, OSEM+TOF, and OSEM+PSF. Gaussian post-filters of 4-9 mm FWHM were applied to find the parameters that provides harmonized SUV. We determined the SUV-harmonized parameter for each reconstruction algorithm. Then, the 10 PET images simulating clinical scan conditions were respectively generated to evaluate the bias and variability of SUV(max) and SUV(peak). The SUV(max) strongly depended not only on spatial resolution but also on image noise. On the other hand, the SUV(peak) was a robust metric to image noise level. TOF improved the variability of SUV(max) and SUV(peak). Thus, we were able to harmonize the spatial resolution using SUV(peak) based on the phantom study. Because SUV(max) was also strongly affected by image noise, sufficient count statistics is essential for SUV(max) harmonization. We recommended that TOF reconstruction and SUV(peak) metric should be used to harmonize SUV.

Original languageEnglish
Pages (from-to)735-745
Number of pages11
JournalNihon Hōshasen Gijutsu Gakkai zasshi
Volume71
Issue number9
DOIs
Publication statusPublished - Sep 1 2015
Externally publishedYes

Fingerprint

Neoplasms
Therapeutics

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Harmonization of Standardized Uptake Value among Different Generation PET/ CT Cameras Based on a Phantom Experiment -Utility of SUV(peak). / Akamatsu, Go; Nishida, Hiroyuki; Fujino, Akira; Ohnishi, Akihito; Ikari, Yasuhiko; Nishio, Tomoyuki; Maebatake, Akira; Sasaki, Masayuki; Senda, Michio.

In: Nihon Hōshasen Gijutsu Gakkai zasshi, Vol. 71, No. 9, 01.09.2015, p. 735-745.

Research output: Contribution to journalArticle

Akamatsu, Go ; Nishida, Hiroyuki ; Fujino, Akira ; Ohnishi, Akihito ; Ikari, Yasuhiko ; Nishio, Tomoyuki ; Maebatake, Akira ; Sasaki, Masayuki ; Senda, Michio. / Harmonization of Standardized Uptake Value among Different Generation PET/ CT Cameras Based on a Phantom Experiment -Utility of SUV(peak). In: Nihon Hōshasen Gijutsu Gakkai zasshi. 2015 ; Vol. 71, No. 9. pp. 735-745.
@article{2e997b0657df4ddb9a8131849be347e6,
title = "Harmonization of Standardized Uptake Value among Different Generation PET/ CT Cameras Based on a Phantom Experiment -Utility of SUV(peak)",
abstract = "Standardized uptake value (SUV) has been widely used as a semi-quantitative metric of uptake in FDGPET/ CT for diagnosis of malignant tumors and evaluation of tumor therapies. However, the SUV depends on various factors including PET/CT scanner specifications and reconstruction parameters. The purpose of this study is to harmonize the SUV among two PET/CT models of different generation: two units of Discovery ST Elite Performance(DSTEP) and Discovery 690 (D690) PET/CT scanners. The NEMA body phantom filled with 18F solution was scanned for 30 minutes in list-mode. The D690 PET images were reconstructed with OSEM, OSEM+TOF, and OSEM+PSF. Gaussian post-filters of 4-9 mm FWHM were applied to find the parameters that provides harmonized SUV. We determined the SUV-harmonized parameter for each reconstruction algorithm. Then, the 10 PET images simulating clinical scan conditions were respectively generated to evaluate the bias and variability of SUV(max) and SUV(peak). The SUV(max) strongly depended not only on spatial resolution but also on image noise. On the other hand, the SUV(peak) was a robust metric to image noise level. TOF improved the variability of SUV(max) and SUV(peak). Thus, we were able to harmonize the spatial resolution using SUV(peak) based on the phantom study. Because SUV(max) was also strongly affected by image noise, sufficient count statistics is essential for SUV(max) harmonization. We recommended that TOF reconstruction and SUV(peak) metric should be used to harmonize SUV.",
author = "Go Akamatsu and Hiroyuki Nishida and Akira Fujino and Akihito Ohnishi and Yasuhiko Ikari and Tomoyuki Nishio and Akira Maebatake and Masayuki Sasaki and Michio Senda",
year = "2015",
month = "9",
day = "1",
doi = "10.6009/jjrt.2015_JSRT_71.9.735",
language = "English",
volume = "71",
pages = "735--745",
journal = "Nippon Hoshasen Gijutsu Gakkai zasshi",
issn = "0369-4305",
publisher = "Nihon Hoshasen Gijutsu Gakkai/Japanese Society of Radiological Technology",
number = "9",

}

TY - JOUR

T1 - Harmonization of Standardized Uptake Value among Different Generation PET/ CT Cameras Based on a Phantom Experiment -Utility of SUV(peak)

AU - Akamatsu, Go

AU - Nishida, Hiroyuki

AU - Fujino, Akira

AU - Ohnishi, Akihito

AU - Ikari, Yasuhiko

AU - Nishio, Tomoyuki

AU - Maebatake, Akira

AU - Sasaki, Masayuki

AU - Senda, Michio

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Standardized uptake value (SUV) has been widely used as a semi-quantitative metric of uptake in FDGPET/ CT for diagnosis of malignant tumors and evaluation of tumor therapies. However, the SUV depends on various factors including PET/CT scanner specifications and reconstruction parameters. The purpose of this study is to harmonize the SUV among two PET/CT models of different generation: two units of Discovery ST Elite Performance(DSTEP) and Discovery 690 (D690) PET/CT scanners. The NEMA body phantom filled with 18F solution was scanned for 30 minutes in list-mode. The D690 PET images were reconstructed with OSEM, OSEM+TOF, and OSEM+PSF. Gaussian post-filters of 4-9 mm FWHM were applied to find the parameters that provides harmonized SUV. We determined the SUV-harmonized parameter for each reconstruction algorithm. Then, the 10 PET images simulating clinical scan conditions were respectively generated to evaluate the bias and variability of SUV(max) and SUV(peak). The SUV(max) strongly depended not only on spatial resolution but also on image noise. On the other hand, the SUV(peak) was a robust metric to image noise level. TOF improved the variability of SUV(max) and SUV(peak). Thus, we were able to harmonize the spatial resolution using SUV(peak) based on the phantom study. Because SUV(max) was also strongly affected by image noise, sufficient count statistics is essential for SUV(max) harmonization. We recommended that TOF reconstruction and SUV(peak) metric should be used to harmonize SUV.

AB - Standardized uptake value (SUV) has been widely used as a semi-quantitative metric of uptake in FDGPET/ CT for diagnosis of malignant tumors and evaluation of tumor therapies. However, the SUV depends on various factors including PET/CT scanner specifications and reconstruction parameters. The purpose of this study is to harmonize the SUV among two PET/CT models of different generation: two units of Discovery ST Elite Performance(DSTEP) and Discovery 690 (D690) PET/CT scanners. The NEMA body phantom filled with 18F solution was scanned for 30 minutes in list-mode. The D690 PET images were reconstructed with OSEM, OSEM+TOF, and OSEM+PSF. Gaussian post-filters of 4-9 mm FWHM were applied to find the parameters that provides harmonized SUV. We determined the SUV-harmonized parameter for each reconstruction algorithm. Then, the 10 PET images simulating clinical scan conditions were respectively generated to evaluate the bias and variability of SUV(max) and SUV(peak). The SUV(max) strongly depended not only on spatial resolution but also on image noise. On the other hand, the SUV(peak) was a robust metric to image noise level. TOF improved the variability of SUV(max) and SUV(peak). Thus, we were able to harmonize the spatial resolution using SUV(peak) based on the phantom study. Because SUV(max) was also strongly affected by image noise, sufficient count statistics is essential for SUV(max) harmonization. We recommended that TOF reconstruction and SUV(peak) metric should be used to harmonize SUV.

UR - http://www.scopus.com/inward/record.url?scp=84946417057&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946417057&partnerID=8YFLogxK

U2 - 10.6009/jjrt.2015_JSRT_71.9.735

DO - 10.6009/jjrt.2015_JSRT_71.9.735

M3 - Article

C2 - 26400557

AN - SCOPUS:84946417057

VL - 71

SP - 735

EP - 745

JO - Nippon Hoshasen Gijutsu Gakkai zasshi

JF - Nippon Hoshasen Gijutsu Gakkai zasshi

SN - 0369-4305

IS - 9

ER -