Harvesting human hair cells

John S. Oghalai, Takashi Nakagawa, Herman A. Jenkins, Thomas M. Jung, Ruth Anne Eatock, Jeffrey R. Holt, Newton J. Coker, William E. Brownell

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

The sensory hair cells of the inner ear are responsible for converting balance and hearing stimuli into electrical signals. Until recently, all previous studies of hair cell physiology had been performed on tissue obtained from non-mammals and rodents. In primates, hair cells are difficult to access, because they rest within the densest structure of the body, the otic capsule of the temporal bone. In this report, we describe a technique that we have used in physiological studies to harvest living human hair cells. We collected vestibular and cochlear tissue specimens from adult humans undergoing translabyrinthine and transotic surgical approaches for resection of lateral skull base tumors. Viable hair cells were identified and visualized with light microscopy. The ability to study normal hair cells from humans may further the study of normal and pathological human sensation, hair cell regeneration, and genetic causes of balance and hearing disorders.

Original languageEnglish
Pages (from-to)9-16
Number of pages8
JournalAnnals of Otology, Rhinology and Laryngology
Volume109
Issue number1
DOIs
Publication statusPublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

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