Heart failure as an autonomic nervous system dysfunction

Takuya Kishi

Research output: Contribution to journalReview article

93 Citations (Scopus)

Abstract

In heart failure, it has been recognized that the sympathetic nervous system (SNS) is activated and the imbalance of the activity of the SNS and vagal activity interaction occurs. The abnormal activation of the SNS leads to further worsening of heart failure. Many previous clinical and basic studies have demonstrated that the abnormal activation of the SNS is caused by the enhancement of excitatory inputs including changes in: (1) peripheral baroreceptor and chemoreceptor reflexes; (2) chemical mediators that control sympathetic outflow; and (3) central sites that integrate sympathetic outflow. In particular, the abnormalities in central SNS regulation due to the renin angiotensin system-oxidative stress axis have recently been in focus. In the treatment of heart failure, the inhibition of the activated SNS, such as with beta-blockers and/or exercise training, is important. Furthermore, many experimental studies have demonstrated that vagal stimulation has beneficial effects on heart failure, and recently several clinical studies have also demonstrated that vagal stimulation is a possible novel therapy for heart failure. In conclusion, we must recognize that heart failure is a complex syndrome with an autonomic nervous system dysfunction, and that the autonomic imbalance with the activation of the SNS and the reduction of vagal activity should be treated.

Original languageEnglish
Pages (from-to)117-122
Number of pages6
JournalJournal of Cardiology
Volume59
Issue number2
DOIs
Publication statusPublished - Mar 1 2012

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Autonomic Nervous System
Sympathetic Nervous System
Heart Failure
Baroreflex
Renin-Angiotensin System
Treatment Failure
Oxidative Stress
Central Nervous System
Exercise

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Heart failure as an autonomic nervous system dysfunction. / Kishi, Takuya.

In: Journal of Cardiology, Vol. 59, No. 2, 01.03.2012, p. 117-122.

Research output: Contribution to journalReview article

Kishi, Takuya. / Heart failure as an autonomic nervous system dysfunction. In: Journal of Cardiology. 2012 ; Vol. 59, No. 2. pp. 117-122.
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