Heart failure with reduced ejection fraction

comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas

Pooja Dewan, Pardeep S. Jhund, Li Shen, Mark C. Petrie, William T. Abraham, M. Atif Ali, Chen Huan Chen, Akshay S. Desai, Kenneth Dickstein, Jun Huang, Songsak Kiatchoosakun, Kee Sik Kim, Lars Køber, Wen Ter Lai, Yuhua Liao, Ulrik M. Mogensen, Byung Hee Oh, Milton Packer, Jean L. Rouleau, Victor Shi & 7 others Antonio S. Sibulo, Scott D. Solomon, Piyamitr Sritara, Karl Swedberg, Hiroyuki Tsutsui, Michael R. Zile, John J.V. McMurray

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aims: Nearly 60% of the world's population lives in Asia but little is known about the characteristics and outcomes of Asian patients with heart failure with reduced ejection fraction (HFrEF) compared to other areas of the world. Methods and results: We pooled two, large, global trials, with similar design, in 13 174 patients with HFrEF (patient distribution: China 833, India 1390, Japan 209, Korea 223, Philippines 223, Taiwan 199 and Thailand 95, Western Europe 3521, Eastern Europe 4758, North America 613, and Latin America 1110). Asian patients were younger (55.0–63.9 years) than in Western Europe (67.9 years) and North America (66.6 years). Diuretics and devices were used less, and digoxin used more, in Asia. Mineralocorticoid receptor antagonist use was higher in China (66.3%), the Philippines (64.1%) and Latin America (62.8%) compared to Europe and North America (range 32.8% to 49.6%). The rate of cardiovascular death/heart failure hospitalization was higher in Asia (e.g. Taiwan 17.2, China 14.9 per 100 patient-years) than in Western Europe (10.4) and North America (12.8). However, the adjusted risk of cardiovascular death was higher in many Asian countries than in Western Europe (except Japan) and the risk of heart failure hospitalization was lower in India and in the Philippines than in Western Europe, but significantly higher in China, Japan, and Taiwan. Conclusion: Patient characteristics and outcomes vary between Asia and other regions and between Asian countries. These variations may reflect several factors, including geography, climate and environment, diet and lifestyle, health care systems, genetics and socioeconomic influences.

Original languageEnglish
Pages (from-to)577-587
Number of pages11
JournalEuropean Journal of Heart Failure
Volume21
Issue number5
DOIs
Publication statusPublished - May 1 2019

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Heart Failure
North America
Philippines
China
Taiwan
Japan
Latin America
India
Hospitalization
Mineralocorticoid Receptor Antagonists
Eastern Europe
Geography
Digoxin
Thailand
Korea
Climate
Diuretics
Life Style
Diet
Delivery of Health Care

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Heart failure with reduced ejection fraction : comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas. / Dewan, Pooja; Jhund, Pardeep S.; Shen, Li; Petrie, Mark C.; Abraham, William T.; Atif Ali, M.; Chen, Chen Huan; Desai, Akshay S.; Dickstein, Kenneth; Huang, Jun; Kiatchoosakun, Songsak; Kim, Kee Sik; Køber, Lars; Lai, Wen Ter; Liao, Yuhua; Mogensen, Ulrik M.; Oh, Byung Hee; Packer, Milton; Rouleau, Jean L.; Shi, Victor; Sibulo, Antonio S.; Solomon, Scott D.; Sritara, Piyamitr; Swedberg, Karl; Tsutsui, Hiroyuki; Zile, Michael R.; McMurray, John J.V.

In: European Journal of Heart Failure, Vol. 21, No. 5, 01.05.2019, p. 577-587.

Research output: Contribution to journalArticle

Dewan, P, Jhund, PS, Shen, L, Petrie, MC, Abraham, WT, Atif Ali, M, Chen, CH, Desai, AS, Dickstein, K, Huang, J, Kiatchoosakun, S, Kim, KS, Køber, L, Lai, WT, Liao, Y, Mogensen, UM, Oh, BH, Packer, M, Rouleau, JL, Shi, V, Sibulo, AS, Solomon, SD, Sritara, P, Swedberg, K, Tsutsui, H, Zile, MR & McMurray, JJV 2019, 'Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas', European Journal of Heart Failure, vol. 21, no. 5, pp. 577-587. https://doi.org/10.1002/ejhf.1347
Dewan, Pooja ; Jhund, Pardeep S. ; Shen, Li ; Petrie, Mark C. ; Abraham, William T. ; Atif Ali, M. ; Chen, Chen Huan ; Desai, Akshay S. ; Dickstein, Kenneth ; Huang, Jun ; Kiatchoosakun, Songsak ; Kim, Kee Sik ; Køber, Lars ; Lai, Wen Ter ; Liao, Yuhua ; Mogensen, Ulrik M. ; Oh, Byung Hee ; Packer, Milton ; Rouleau, Jean L. ; Shi, Victor ; Sibulo, Antonio S. ; Solomon, Scott D. ; Sritara, Piyamitr ; Swedberg, Karl ; Tsutsui, Hiroyuki ; Zile, Michael R. ; McMurray, John J.V. / Heart failure with reduced ejection fraction : comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas. In: European Journal of Heart Failure. 2019 ; Vol. 21, No. 5. pp. 577-587.
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abstract = "Aims: Nearly 60{\%} of the world's population lives in Asia but little is known about the characteristics and outcomes of Asian patients with heart failure with reduced ejection fraction (HFrEF) compared to other areas of the world. Methods and results: We pooled two, large, global trials, with similar design, in 13 174 patients with HFrEF (patient distribution: China 833, India 1390, Japan 209, Korea 223, Philippines 223, Taiwan 199 and Thailand 95, Western Europe 3521, Eastern Europe 4758, North America 613, and Latin America 1110). Asian patients were younger (55.0–63.9 years) than in Western Europe (67.9 years) and North America (66.6 years). Diuretics and devices were used less, and digoxin used more, in Asia. Mineralocorticoid receptor antagonist use was higher in China (66.3{\%}), the Philippines (64.1{\%}) and Latin America (62.8{\%}) compared to Europe and North America (range 32.8{\%} to 49.6{\%}). The rate of cardiovascular death/heart failure hospitalization was higher in Asia (e.g. Taiwan 17.2, China 14.9 per 100 patient-years) than in Western Europe (10.4) and North America (12.8). However, the adjusted risk of cardiovascular death was higher in many Asian countries than in Western Europe (except Japan) and the risk of heart failure hospitalization was lower in India and in the Philippines than in Western Europe, but significantly higher in China, Japan, and Taiwan. Conclusion: Patient characteristics and outcomes vary between Asia and other regions and between Asian countries. These variations may reflect several factors, including geography, climate and environment, diet and lifestyle, health care systems, genetics and socioeconomic influences.",
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T2 - comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas

AU - Dewan, Pooja

AU - Jhund, Pardeep S.

AU - Shen, Li

AU - Petrie, Mark C.

AU - Abraham, William T.

AU - Atif Ali, M.

AU - Chen, Chen Huan

AU - Desai, Akshay S.

AU - Dickstein, Kenneth

AU - Huang, Jun

AU - Kiatchoosakun, Songsak

AU - Kim, Kee Sik

AU - Køber, Lars

AU - Lai, Wen Ter

AU - Liao, Yuhua

AU - Mogensen, Ulrik M.

AU - Oh, Byung Hee

AU - Packer, Milton

AU - Rouleau, Jean L.

AU - Shi, Victor

AU - Sibulo, Antonio S.

AU - Solomon, Scott D.

AU - Sritara, Piyamitr

AU - Swedberg, Karl

AU - Tsutsui, Hiroyuki

AU - Zile, Michael R.

AU - McMurray, John J.V.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Aims: Nearly 60% of the world's population lives in Asia but little is known about the characteristics and outcomes of Asian patients with heart failure with reduced ejection fraction (HFrEF) compared to other areas of the world. Methods and results: We pooled two, large, global trials, with similar design, in 13 174 patients with HFrEF (patient distribution: China 833, India 1390, Japan 209, Korea 223, Philippines 223, Taiwan 199 and Thailand 95, Western Europe 3521, Eastern Europe 4758, North America 613, and Latin America 1110). Asian patients were younger (55.0–63.9 years) than in Western Europe (67.9 years) and North America (66.6 years). Diuretics and devices were used less, and digoxin used more, in Asia. Mineralocorticoid receptor antagonist use was higher in China (66.3%), the Philippines (64.1%) and Latin America (62.8%) compared to Europe and North America (range 32.8% to 49.6%). The rate of cardiovascular death/heart failure hospitalization was higher in Asia (e.g. Taiwan 17.2, China 14.9 per 100 patient-years) than in Western Europe (10.4) and North America (12.8). However, the adjusted risk of cardiovascular death was higher in many Asian countries than in Western Europe (except Japan) and the risk of heart failure hospitalization was lower in India and in the Philippines than in Western Europe, but significantly higher in China, Japan, and Taiwan. Conclusion: Patient characteristics and outcomes vary between Asia and other regions and between Asian countries. These variations may reflect several factors, including geography, climate and environment, diet and lifestyle, health care systems, genetics and socioeconomic influences.

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