Heat-inducible gene expression system by applying alternating magnetic field to magnetic nanoparticles

Masaki Yamaguchi, Akira Ito, Akihiko Ono, Kawabe Yoshinori, Masamichi Kamihira

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

By combining synthetic biology with nanotechnology, we demonstrate remote controlled gene expression using a magnetic field. Magnetite nanoparticles, which generate heat under an alternating magnetic field, have been developed to label cells. Magnetite nanoparticles and heat-induced therapeutic genes were introduced into tumor xenografts. The magnetically triggered gene expression resulted in tumor growth inhibition. This system shows great potential for controlling target gene expression in a space and time selective manner and may be used for remote control of cell functions via gene expression.

Original languageEnglish
Pages (from-to)273-279
Number of pages7
JournalACS Synthetic Biology
Volume3
Issue number5
DOIs
Publication statusPublished - May 16 2014

Fingerprint

Magnetic Fields
Gene expression
Nanoparticles
Magnetite Nanoparticles
Hot Temperature
Magnetic fields
Magnetite nanoparticles
Gene Expression
Tumors
Synthetic Biology
Nanotechnology
Remote control
Heterografts
Labels
Neoplasms
Genes
Growth
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

Cite this

Heat-inducible gene expression system by applying alternating magnetic field to magnetic nanoparticles. / Yamaguchi, Masaki; Ito, Akira; Ono, Akihiko; Yoshinori, Kawabe; Kamihira, Masamichi.

In: ACS Synthetic Biology, Vol. 3, No. 5, 16.05.2014, p. 273-279.

Research output: Contribution to journalArticle

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