Heat-inducible gene expression system by applying alternating magnetic field to magnetic nanoparticles

Masaki Yamaguchi, Akira Ito, Akihiko Ono, Kawabe Yoshinori, Masamichi Kamihira

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

By combining synthetic biology with nanotechnology, we demonstrate remote controlled gene expression using a magnetic field. Magnetite nanoparticles, which generate heat under an alternating magnetic field, have been developed to label cells. Magnetite nanoparticles and heat-induced therapeutic genes were introduced into tumor xenografts. The magnetically triggered gene expression resulted in tumor growth inhibition. This system shows great potential for controlling target gene expression in a space and time selective manner and may be used for remote control of cell functions via gene expression.

Original languageEnglish
Pages (from-to)273-279
Number of pages7
JournalACS Synthetic Biology
Volume3
Issue number5
DOIs
Publication statusPublished - May 16 2014

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

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