Heightened IgE response to mite antigens in inflammatory neuropathies

Izumi Horiuchi, Yuji Kawano, Kenji Yamasaki, Hidenori Matsuo, Motozumi Minohara, Tatsufumi Nakamura, Hideyuki Hashiguchi, Yasumasa Ohyagi, Takeshi Yamada, Jun-Ichi Kira

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Abstract

In order to clarify the IgE response to common environmental antigens, we measured the serum total IgE and allergen-specific IgE in 50 patients with Guillain-Barre syndrome (GBS), nine patients with Fisher syndrome (FS), 14 patients with chronic inflammatory demyelinating polyneuropathy (CIDP), 18 patients with mononeuritis multiplex (MNM), 43 patients with neurodegenerative disorders and 82 healthy controls by ELISA. The total IgE level was significantly higher in patients with GBS (median=135 U/ml, P<0.05), CIDP (median=175 U/ml, P<0.05) and MNM (median=199 U/ml, P<0.05), than in the healthy controls (median=79 U/ml), but not in those patients with neurodegenerative disorders. The specific IgE to Dermatophagoides pteronyssinus was significantly higher in the patients with GBS (56%, P<0.01) and MNM (72%, P<0.005) than in the healthy controls (32%). The level of specific IgE to Dermatophagoides farinae tended to be higher in the patients with GBS than in the healthy controls (0.05<P<0.1). The patients with CIDP and MNM also showed a similar increase in the frequency of mite antigen-specific IgE. As a result, the heightened IgE responses to mite antigens may therefore in part be related to the mechanism of inflammatory neuropathies. On the other hand, such heightened IgE responses in these inflammatory neuropathies may be a reflection of Th2 cell overactivity, which may induce an intense synthesis of autoantibodies against the peripheral nerves. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)77-80
Number of pages4
JournalJournal of the Neurological Sciences
Volume166
Issue number2
DOIs
Publication statusPublished - Jul 1 1999

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Mites
Immunoglobulin E
Antigens
Mononeuropathies
Guillain-Barre Syndrome
Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Neurodegenerative Diseases
Miller Fisher Syndrome
Dermatophagoides farinae
Dermatophagoides pteronyssinus
Th2 Cells
Peripheral Nerves
Autoantibodies
Allergens
Enzyme-Linked Immunosorbent Assay

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Heightened IgE response to mite antigens in inflammatory neuropathies. / Horiuchi, Izumi; Kawano, Yuji; Yamasaki, Kenji; Matsuo, Hidenori; Minohara, Motozumi; Nakamura, Tatsufumi; Hashiguchi, Hideyuki; Ohyagi, Yasumasa; Yamada, Takeshi; Kira, Jun-Ichi.

In: Journal of the Neurological Sciences, Vol. 166, No. 2, 01.07.1999, p. 77-80.

Research output: Contribution to journalArticle

Horiuchi, I, Kawano, Y, Yamasaki, K, Matsuo, H, Minohara, M, Nakamura, T, Hashiguchi, H, Ohyagi, Y, Yamada, T & Kira, J-I 1999, 'Heightened IgE response to mite antigens in inflammatory neuropathies', Journal of the Neurological Sciences, vol. 166, no. 2, pp. 77-80. https://doi.org/10.1016/S0022-510X(99)00098-2
Horiuchi I, Kawano Y, Yamasaki K, Matsuo H, Minohara M, Nakamura T et al. Heightened IgE response to mite antigens in inflammatory neuropathies. Journal of the Neurological Sciences. 1999 Jul 1;166(2):77-80. https://doi.org/10.1016/S0022-510X(99)00098-2
Horiuchi, Izumi ; Kawano, Yuji ; Yamasaki, Kenji ; Matsuo, Hidenori ; Minohara, Motozumi ; Nakamura, Tatsufumi ; Hashiguchi, Hideyuki ; Ohyagi, Yasumasa ; Yamada, Takeshi ; Kira, Jun-Ichi. / Heightened IgE response to mite antigens in inflammatory neuropathies. In: Journal of the Neurological Sciences. 1999 ; Vol. 166, No. 2. pp. 77-80.
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