Helicobacter pylori infection is a potential protective factor against conventional multiple sclerosis in the Japanese population

Wei Li, Motozumi Minohara, Jen Jen Su, Takeshi Matsuoka, Manabu Osoegawa, Takaaki Ishizu, Jun ichi Kira

Research output: Contribution to journalArticle

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Abstract

Persistent Helicobacter pylori (H. pylori) infection is a chronic inflammatory stimulus to hosts with an inverse correlation to atopic disorders. In this study, a total of 105 consecutive multiple sclerosis (MS) patients were divided into 52 opticospinal MS (OSMS) and 53 conventional MS (CMS), and their sera, along with those from 85 healthy controls (HC), were examined by an enzyme-linked immunosorbent assay using antibodies against H. pylori. H. pylori seropositivity was significantly lower in patients with CMS (22.6%) compared with HC (42.4%) and patients with OSMS (51.9%) (p = 0.0180 and p = 0.0019, respectively). In patients with CMS, H. pylori seropositivity showed a significant inverse association with mean EDSS score and fulfillment of McDonald MRI criteria for space (OR = 0.61, p = 0.0344 and OR = 0.11, p = 0.0297). These findings suggest that H. pylori infection is a protective factor against CMS in Japanese.

Original languageEnglish
Pages (from-to)227-231
Number of pages5
JournalJournal of Neuroimmunology
Volume184
Issue number1-2
DOIs
Publication statusPublished - Mar 1 2007
Externally publishedYes

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Helicobacter Infections
Helicobacter pylori
Multiple Sclerosis
Population
Enzyme-Linked Immunosorbent Assay
Protective Factors
Antibodies
Serum
Opticospinal Multiple Sclerosis

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Cite this

Helicobacter pylori infection is a potential protective factor against conventional multiple sclerosis in the Japanese population. / Li, Wei; Minohara, Motozumi; Su, Jen Jen; Matsuoka, Takeshi; Osoegawa, Manabu; Ishizu, Takaaki; Kira, Jun ichi.

In: Journal of Neuroimmunology, Vol. 184, No. 1-2, 01.03.2007, p. 227-231.

Research output: Contribution to journalArticle

Li, Wei ; Minohara, Motozumi ; Su, Jen Jen ; Matsuoka, Takeshi ; Osoegawa, Manabu ; Ishizu, Takaaki ; Kira, Jun ichi. / Helicobacter pylori infection is a potential protective factor against conventional multiple sclerosis in the Japanese population. In: Journal of Neuroimmunology. 2007 ; Vol. 184, No. 1-2. pp. 227-231.
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AU - Ishizu, Takaaki

AU - Kira, Jun ichi

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