TY - JOUR
T1 - Helicobacter pylori infection is a potential protective factor against conventional multiple sclerosis in the Japanese population
AU - Li, Wei
AU - Minohara, Motozumi
AU - Su, Jen Jen
AU - Matsuoka, Takeshi
AU - Osoegawa, Manabu
AU - Ishizu, Takaaki
AU - Kira, Jun ichi
N1 - Funding Information:
This work was supported by grants from the Ministry of Education, Culture, Sports, Science and Technology, Japan. The Neuroimmunological Disease Research Committee and the Ministry of Health, Labor and Welfare, Japan, for Research on Brain Science.
PY - 2007/3
Y1 - 2007/3
N2 - Persistent Helicobacter pylori (H. pylori) infection is a chronic inflammatory stimulus to hosts with an inverse correlation to atopic disorders. In this study, a total of 105 consecutive multiple sclerosis (MS) patients were divided into 52 opticospinal MS (OSMS) and 53 conventional MS (CMS), and their sera, along with those from 85 healthy controls (HC), were examined by an enzyme-linked immunosorbent assay using antibodies against H. pylori. H. pylori seropositivity was significantly lower in patients with CMS (22.6%) compared with HC (42.4%) and patients with OSMS (51.9%) (p = 0.0180 and p = 0.0019, respectively). In patients with CMS, H. pylori seropositivity showed a significant inverse association with mean EDSS score and fulfillment of McDonald MRI criteria for space (OR = 0.61, p = 0.0344 and OR = 0.11, p = 0.0297). These findings suggest that H. pylori infection is a protective factor against CMS in Japanese.
AB - Persistent Helicobacter pylori (H. pylori) infection is a chronic inflammatory stimulus to hosts with an inverse correlation to atopic disorders. In this study, a total of 105 consecutive multiple sclerosis (MS) patients were divided into 52 opticospinal MS (OSMS) and 53 conventional MS (CMS), and their sera, along with those from 85 healthy controls (HC), were examined by an enzyme-linked immunosorbent assay using antibodies against H. pylori. H. pylori seropositivity was significantly lower in patients with CMS (22.6%) compared with HC (42.4%) and patients with OSMS (51.9%) (p = 0.0180 and p = 0.0019, respectively). In patients with CMS, H. pylori seropositivity showed a significant inverse association with mean EDSS score and fulfillment of McDonald MRI criteria for space (OR = 0.61, p = 0.0344 and OR = 0.11, p = 0.0297). These findings suggest that H. pylori infection is a protective factor against CMS in Japanese.
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U2 - 10.1016/j.jneuroim.2006.12.010
DO - 10.1016/j.jneuroim.2006.12.010
M3 - Article
C2 - 17296235
AN - SCOPUS:33847609214
SN - 0165-5728
VL - 184
SP - 227
EP - 231
JO - Advances in Neuroimmunology
JF - Advances in Neuroimmunology
IS - 1-2
ER -