Helicobacter Pylori infection is a significant risk for modified lipid profile in Japanese male subjects

Hiroki Satoh, Yasuaki Saijo, Eiji Yoshioka, Hiroyuki Tsutsui

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62 Citations (Scopus)


Aim: Helicobacter pylori infection was associated with the risk of cardiovascular disease; however, the relation between Helicobacter pylori infection and the lipid profile has not been fully established. Methods: We measured anti-Helicobacter Pylori antibody concentration and lipid profiles in 6,289 Japanese subjects aged 21-64 years (5,077 male and 1,212 female). Results: The prevalence of Helicobacter pylori-seropositive subjects was 46.8% and 39.6% in men and women, respectively. Adjusted mean values of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol in men were significantly higher and lower in Helicobacter pylori-seropositive than-negative subjects, respectively, (LDL-cholesterol: 129.0±0.8 vs. 125.3 ±0.7 mg/dL, p<0.001, HDL-cholesterol: 54.6±0.3 vs. 56.6±0.3 mg/dL, p<0.01), whereas these associations were not significant in female subjects. Moreover, the odds ratio of Helicobacter pylori infection for high LDL-cholesteremia and low HDL-cholesteremia in male subjects was 1.23 (95% CI (confidence interval): 1.08-1.40, p<0.05) and 1.29 (95% CI: 1.03-1.59, p<0.05), respectively. Female subjects did not have such associations. Conclusions: The present study demonstrates that Helicobacter pylori infection is significantly associated with high LDL-cholesteremia and low HDL-cholesteremia in Japanese male subjects.

Original languageEnglish
Pages (from-to)1041-1048
Number of pages8
JournalJournal of atherosclerosis and thrombosis
Issue number10
Publication statusPublished - 2010
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine
  • Biochemistry, medical


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