Abstract
Aim: Helicobacter pylori infection was associated with the risk of cardiovascular disease; however, the relation between Helicobacter pylori infection and the lipid profile has not been fully established. Methods: We measured anti-Helicobacter Pylori antibody concentration and lipid profiles in 6,289 Japanese subjects aged 21-64 years (5,077 male and 1,212 female). Results: The prevalence of Helicobacter pylori-seropositive subjects was 46.8% and 39.6% in men and women, respectively. Adjusted mean values of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol in men were significantly higher and lower in Helicobacter pylori-seropositive than-negative subjects, respectively, (LDL-cholesterol: 129.0±0.8 vs. 125.3 ±0.7 mg/dL, p<0.001, HDL-cholesterol: 54.6±0.3 vs. 56.6±0.3 mg/dL, p<0.01), whereas these associations were not significant in female subjects. Moreover, the odds ratio of Helicobacter pylori infection for high LDL-cholesteremia and low HDL-cholesteremia in male subjects was 1.23 (95% CI (confidence interval): 1.08-1.40, p<0.05) and 1.29 (95% CI: 1.03-1.59, p<0.05), respectively. Female subjects did not have such associations. Conclusions: The present study demonstrates that Helicobacter pylori infection is significantly associated with high LDL-cholesteremia and low HDL-cholesteremia in Japanese male subjects.
| Original language | English |
|---|---|
| Pages (from-to) | 1041-1048 |
| Number of pages | 8 |
| Journal | Journal of atherosclerosis and thrombosis |
| Volume | 17 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - Jan 1 2010 |
| Externally published | Yes |
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All Science Journal Classification (ASJC) codes
- Internal Medicine
- Cardiology and Cardiovascular Medicine
- Biochemistry, medical
Cite this
Helicobacter Pylori infection is a significant risk for modified lipid profile in Japanese male subjects. / Satoh, Hiroki; Saijo, Yasuaki; Yoshioka, Eiji; Tsutsui, Hiroyuki.
In: Journal of atherosclerosis and thrombosis, Vol. 17, No. 10, 01.01.2010, p. 1041-1048.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Helicobacter Pylori infection is a significant risk for modified lipid profile in Japanese male subjects
AU - Satoh, Hiroki
AU - Saijo, Yasuaki
AU - Yoshioka, Eiji
AU - Tsutsui, Hiroyuki
PY - 2010/1/1
Y1 - 2010/1/1
N2 - Aim: Helicobacter pylori infection was associated with the risk of cardiovascular disease; however, the relation between Helicobacter pylori infection and the lipid profile has not been fully established. Methods: We measured anti-Helicobacter Pylori antibody concentration and lipid profiles in 6,289 Japanese subjects aged 21-64 years (5,077 male and 1,212 female). Results: The prevalence of Helicobacter pylori-seropositive subjects was 46.8% and 39.6% in men and women, respectively. Adjusted mean values of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol in men were significantly higher and lower in Helicobacter pylori-seropositive than-negative subjects, respectively, (LDL-cholesterol: 129.0±0.8 vs. 125.3 ±0.7 mg/dL, p<0.001, HDL-cholesterol: 54.6±0.3 vs. 56.6±0.3 mg/dL, p<0.01), whereas these associations were not significant in female subjects. Moreover, the odds ratio of Helicobacter pylori infection for high LDL-cholesteremia and low HDL-cholesteremia in male subjects was 1.23 (95% CI (confidence interval): 1.08-1.40, p<0.05) and 1.29 (95% CI: 1.03-1.59, p<0.05), respectively. Female subjects did not have such associations. Conclusions: The present study demonstrates that Helicobacter pylori infection is significantly associated with high LDL-cholesteremia and low HDL-cholesteremia in Japanese male subjects.
AB - Aim: Helicobacter pylori infection was associated with the risk of cardiovascular disease; however, the relation between Helicobacter pylori infection and the lipid profile has not been fully established. Methods: We measured anti-Helicobacter Pylori antibody concentration and lipid profiles in 6,289 Japanese subjects aged 21-64 years (5,077 male and 1,212 female). Results: The prevalence of Helicobacter pylori-seropositive subjects was 46.8% and 39.6% in men and women, respectively. Adjusted mean values of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol in men were significantly higher and lower in Helicobacter pylori-seropositive than-negative subjects, respectively, (LDL-cholesterol: 129.0±0.8 vs. 125.3 ±0.7 mg/dL, p<0.001, HDL-cholesterol: 54.6±0.3 vs. 56.6±0.3 mg/dL, p<0.01), whereas these associations were not significant in female subjects. Moreover, the odds ratio of Helicobacter pylori infection for high LDL-cholesteremia and low HDL-cholesteremia in male subjects was 1.23 (95% CI (confidence interval): 1.08-1.40, p<0.05) and 1.29 (95% CI: 1.03-1.59, p<0.05), respectively. Female subjects did not have such associations. Conclusions: The present study demonstrates that Helicobacter pylori infection is significantly associated with high LDL-cholesteremia and low HDL-cholesteremia in Japanese male subjects.
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U2 - 10.5551/jat.5157
DO - 10.5551/jat.5157
M3 - Article
VL - 17
SP - 1041
EP - 1048
JO - Journal of Atherosclerosis and Thrombosis
JF - Journal of Atherosclerosis and Thrombosis
SN - 1340-3478
IS - 10
ER -