Helix pomatia agglutinin binding activity is a predictor of survival time for patients with gastric carcinoma

Yoshihiro Kakeji, Shunichi Tsujitani, Masaki Mori, Yoshihiko Maehara, Keizo Sugimachi

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

The authors used helix pomatia agglutinin (HPA) staining to examine 163 primary gastric carcinoma isolates, using the avidin‐biotin‐peroxidase complex method. The positive HPA staining rate was 59% (96/163) for the primary tumors, and the positive staining correlated well (with statistical significance) with tumor enlargement, penetration, lymphatic invasion, and metastasis (P < 0.01), and with infiltrative spread (P < 0.05). Patients with gastric cancer showing positive HPA staining had a lower survival rate (P < 0.001), particularly when the cancer cells were present on the serosal surface. Careful follow‐up and intensive postoperative therapy are required for patients with an HPA‐positive advanced gastric carcinoma. 68:2438‐2442, 1991.

Original languageEnglish
Pages (from-to)2438-2442
Number of pages5
JournalCancer
Volume68
Issue number11
DOIs
Publication statusPublished - Dec 1 1991

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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