The authors used helix pomatia agglutinin (HPA) staining to examine 163 primary gastric carcinoma isolates, using the avidin‐biotin‐peroxidase complex method. The positive HPA staining rate was 59% (96/163) for the primary tumors, and the positive staining correlated well (with statistical significance) with tumor enlargement, penetration, lymphatic invasion, and metastasis (P < 0.01), and with infiltrative spread (P < 0.05). Patients with gastric cancer showing positive HPA staining had a lower survival rate (P < 0.001), particularly when the cancer cells were present on the serosal surface. Careful follow‐up and intensive postoperative therapy are required for patients with an HPA‐positive advanced gastric carcinoma. 68:2438‐2442, 1991.
|Number of pages||5|
|Publication status||Published - Dec 1 1991|
All Science Journal Classification (ASJC) codes
- Cancer Research