Hematocrit and the risk of cardiovascular disease in a Japanese community

The Hisayama Study

Seiji Gotoh, Jun Hata, Toshiharu Ninomiya, Yoichiro Hirakawa, Masaharu Nagata, Naoko Mukai, Masayo Fukuhara, Fumie Ikeda, Tetsuro Ago, Takanari Kitazono, Yutaka Kiyohara

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives: The association between hematocrit levels and the risk of cardiovascular disease (CVD) has been reported inconsistently. We aimed to investigate the association of hematocrit levels with the development of stroke and coronary heart disease (CHD) in a general Japanese population. Methods: A total of 2585 community-dwelling Japanese individuals aged 40 years or older in 1988 were followed up for 19 years. These subjects were divided into four groups according to the sex-specific quartiles of hematocrit at baseline. Results: During the follow-up, 301 subjects developed stroke (210 ischemic and 91 hemorrhagic) and 187 developed CHD. The risk of ischemic stroke was higher in both the lowest (Q1: men, ≤44.7%; women, ≤39.3%) and the highest (Q4: men, ≥49.7%; women, ≥43.8%) quartiles than in the third quartile (Q3: men, 47.1%-49.6%; women, 41.7%-43.7%) used as a reference (multivariable-adjusted hazard ratios [95% confidence intervals]: Q1, 1.55 [0.99-2.43]; Q2, 1.44 [0.93-2.23]; Q3, 1.00; and Q4, 1.62 [1.06-2.50]; P=0.86 for trend). In contrast, hematocrit levels and the risk of hemorrhagic stroke showed a linear inverse association (Q1, 1.91 [1.03-3.54]; Q2, 1.26 [0.68-2.34]; Q3, 1.00; and Q4, 0.81 [0.41-1.61]; P=0.009 for trend). The risk of CHD increased significantly in Q4 (Q1, 1.13 [0.71-1.80]; Q2, 1.08 [0.69-1.71]; Q3, 1.00; and Q4, 1.60 [1.04-2.46]; P=0.13 for trend). Conclusions: Our findings suggest that both elevated and decreased hematocrit levels are associated with an increased risk of CVD, but the influence of hematocrit is different among subtypes of CVD.

Original languageEnglish
Pages (from-to)199-204
Number of pages6
JournalAtherosclerosis
Volume242
Issue number1
DOIs
Publication statusPublished - Sep 1 2015

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Hematocrit
Cardiovascular Diseases
Stroke
Coronary Disease
Independent Living
Confidence Intervals
Population

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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Hematocrit and the risk of cardiovascular disease in a Japanese community : The Hisayama Study. / Gotoh, Seiji; Hata, Jun; Ninomiya, Toshiharu; Hirakawa, Yoichiro; Nagata, Masaharu; Mukai, Naoko; Fukuhara, Masayo; Ikeda, Fumie; Ago, Tetsuro; Kitazono, Takanari; Kiyohara, Yutaka.

In: Atherosclerosis, Vol. 242, No. 1, 01.09.2015, p. 199-204.

Research output: Contribution to journalArticle

Gotoh, Seiji ; Hata, Jun ; Ninomiya, Toshiharu ; Hirakawa, Yoichiro ; Nagata, Masaharu ; Mukai, Naoko ; Fukuhara, Masayo ; Ikeda, Fumie ; Ago, Tetsuro ; Kitazono, Takanari ; Kiyohara, Yutaka. / Hematocrit and the risk of cardiovascular disease in a Japanese community : The Hisayama Study. In: Atherosclerosis. 2015 ; Vol. 242, No. 1. pp. 199-204.
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abstract = "Objectives: The association between hematocrit levels and the risk of cardiovascular disease (CVD) has been reported inconsistently. We aimed to investigate the association of hematocrit levels with the development of stroke and coronary heart disease (CHD) in a general Japanese population. Methods: A total of 2585 community-dwelling Japanese individuals aged 40 years or older in 1988 were followed up for 19 years. These subjects were divided into four groups according to the sex-specific quartiles of hematocrit at baseline. Results: During the follow-up, 301 subjects developed stroke (210 ischemic and 91 hemorrhagic) and 187 developed CHD. The risk of ischemic stroke was higher in both the lowest (Q1: men, ≤44.7{\%}; women, ≤39.3{\%}) and the highest (Q4: men, ≥49.7{\%}; women, ≥43.8{\%}) quartiles than in the third quartile (Q3: men, 47.1{\%}-49.6{\%}; women, 41.7{\%}-43.7{\%}) used as a reference (multivariable-adjusted hazard ratios [95{\%} confidence intervals]: Q1, 1.55 [0.99-2.43]; Q2, 1.44 [0.93-2.23]; Q3, 1.00; and Q4, 1.62 [1.06-2.50]; P=0.86 for trend). In contrast, hematocrit levels and the risk of hemorrhagic stroke showed a linear inverse association (Q1, 1.91 [1.03-3.54]; Q2, 1.26 [0.68-2.34]; Q3, 1.00; and Q4, 0.81 [0.41-1.61]; P=0.009 for trend). The risk of CHD increased significantly in Q4 (Q1, 1.13 [0.71-1.80]; Q2, 1.08 [0.69-1.71]; Q3, 1.00; and Q4, 1.60 [1.04-2.46]; P=0.13 for trend). Conclusions: Our findings suggest that both elevated and decreased hematocrit levels are associated with an increased risk of CVD, but the influence of hematocrit is different among subtypes of CVD.",
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T1 - Hematocrit and the risk of cardiovascular disease in a Japanese community

T2 - The Hisayama Study

AU - Gotoh, Seiji

AU - Hata, Jun

AU - Ninomiya, Toshiharu

AU - Hirakawa, Yoichiro

AU - Nagata, Masaharu

AU - Mukai, Naoko

AU - Fukuhara, Masayo

AU - Ikeda, Fumie

AU - Ago, Tetsuro

AU - Kitazono, Takanari

AU - Kiyohara, Yutaka

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Objectives: The association between hematocrit levels and the risk of cardiovascular disease (CVD) has been reported inconsistently. We aimed to investigate the association of hematocrit levels with the development of stroke and coronary heart disease (CHD) in a general Japanese population. Methods: A total of 2585 community-dwelling Japanese individuals aged 40 years or older in 1988 were followed up for 19 years. These subjects were divided into four groups according to the sex-specific quartiles of hematocrit at baseline. Results: During the follow-up, 301 subjects developed stroke (210 ischemic and 91 hemorrhagic) and 187 developed CHD. The risk of ischemic stroke was higher in both the lowest (Q1: men, ≤44.7%; women, ≤39.3%) and the highest (Q4: men, ≥49.7%; women, ≥43.8%) quartiles than in the third quartile (Q3: men, 47.1%-49.6%; women, 41.7%-43.7%) used as a reference (multivariable-adjusted hazard ratios [95% confidence intervals]: Q1, 1.55 [0.99-2.43]; Q2, 1.44 [0.93-2.23]; Q3, 1.00; and Q4, 1.62 [1.06-2.50]; P=0.86 for trend). In contrast, hematocrit levels and the risk of hemorrhagic stroke showed a linear inverse association (Q1, 1.91 [1.03-3.54]; Q2, 1.26 [0.68-2.34]; Q3, 1.00; and Q4, 0.81 [0.41-1.61]; P=0.009 for trend). The risk of CHD increased significantly in Q4 (Q1, 1.13 [0.71-1.80]; Q2, 1.08 [0.69-1.71]; Q3, 1.00; and Q4, 1.60 [1.04-2.46]; P=0.13 for trend). Conclusions: Our findings suggest that both elevated and decreased hematocrit levels are associated with an increased risk of CVD, but the influence of hematocrit is different among subtypes of CVD.

AB - Objectives: The association between hematocrit levels and the risk of cardiovascular disease (CVD) has been reported inconsistently. We aimed to investigate the association of hematocrit levels with the development of stroke and coronary heart disease (CHD) in a general Japanese population. Methods: A total of 2585 community-dwelling Japanese individuals aged 40 years or older in 1988 were followed up for 19 years. These subjects were divided into four groups according to the sex-specific quartiles of hematocrit at baseline. Results: During the follow-up, 301 subjects developed stroke (210 ischemic and 91 hemorrhagic) and 187 developed CHD. The risk of ischemic stroke was higher in both the lowest (Q1: men, ≤44.7%; women, ≤39.3%) and the highest (Q4: men, ≥49.7%; women, ≥43.8%) quartiles than in the third quartile (Q3: men, 47.1%-49.6%; women, 41.7%-43.7%) used as a reference (multivariable-adjusted hazard ratios [95% confidence intervals]: Q1, 1.55 [0.99-2.43]; Q2, 1.44 [0.93-2.23]; Q3, 1.00; and Q4, 1.62 [1.06-2.50]; P=0.86 for trend). In contrast, hematocrit levels and the risk of hemorrhagic stroke showed a linear inverse association (Q1, 1.91 [1.03-3.54]; Q2, 1.26 [0.68-2.34]; Q3, 1.00; and Q4, 0.81 [0.41-1.61]; P=0.009 for trend). The risk of CHD increased significantly in Q4 (Q1, 1.13 [0.71-1.80]; Q2, 1.08 [0.69-1.71]; Q3, 1.00; and Q4, 1.60 [1.04-2.46]; P=0.13 for trend). Conclusions: Our findings suggest that both elevated and decreased hematocrit levels are associated with an increased risk of CVD, but the influence of hematocrit is different among subtypes of CVD.

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