Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells

Wai Feng Lim, Tomoko Inoue-Yokoo, Keai Sinn Tan, Mei I. Lai, Daisuke Sugiyama

    Research output: Contribution to journalReview articlepeer-review

    42 Citations (Scopus)

    Abstract

    Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic progenitor cells and mature hematopoietic cells in the presence of a suitable culture system. Establishment of pluripotent stem cells provides a comprehensive model to study early hematopoietic development and has emerged as a powerful research tool to explore regenerative medicine. Nowadays, HSC transplantation and hematopoietic cell transfusion have successfully cured some patients, especially in malignant hematological diseases. Owing to a shortage of donors and a limited number of the cells, hematopoietic cell induction from pluripotent stem cells has been regarded as an alternative source of HSCs and mature hematopoietic cells for intended therapeutic purposes. Pluripotent stem cells are therefore extensively utilized to facilitate better understanding in hematopoietic development by recapitulating embryonic development in vivo, in which efficient strategies can be easily designed and deployed for the generation of hematopoietic lineages in vitro. We hereby review the current progress of hematopoietic cell induction from embryonic stem/induced pluripotent stem cells.

    Original languageEnglish
    Article number71
    JournalStem Cell Research and Therapy
    Volume4
    Issue number3
    DOIs
    Publication statusPublished - 2013

    All Science Journal Classification (ASJC) codes

    • Medicine (miscellaneous)
    • Molecular Medicine
    • Biochemistry, Genetics and Molecular Biology (miscellaneous)
    • Cell Biology

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