Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells

Wai Feng Lim, Tomoko Inoue-Yokoo, Keai Sinn Tan, Mei I. Lai, Daisuke Sugiyama

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Pluripotent stem cells, both embryonic stem cells and induced pluripotent stem cells, are undifferentiated cells that can self-renew and potentially differentiate into all hematopoietic lineages, such as hematopoietic stem cells (HSCs), hematopoietic progenitor cells and mature hematopoietic cells in the presence of a suitable culture system. Establishment of pluripotent stem cells provides a comprehensive model to study early hematopoietic development and has emerged as a powerful research tool to explore regenerative medicine. Nowadays, HSC transplantation and hematopoietic cell transfusion have successfully cured some patients, especially in malignant hematological diseases. Owing to a shortage of donors and a limited number of the cells, hematopoietic cell induction from pluripotent stem cells has been regarded as an alternative source of HSCs and mature hematopoietic cells for intended therapeutic purposes. Pluripotent stem cells are therefore extensively utilized to facilitate better understanding in hematopoietic development by recapitulating embryonic development in vivo, in which efficient strategies can be easily designed and deployed for the generation of hematopoietic lineages in vitro. We hereby review the current progress of hematopoietic cell induction from embryonic stem/induced pluripotent stem cells.

Original languageEnglish
Article number71
JournalStem Cell Research and Therapy
Volume4
Issue number3
DOIs
Publication statusPublished - Jul 15 2013

Fingerprint

Induced Pluripotent Stem Cells
Stem cells
Pluripotent Stem Cells
Cell Differentiation
Hematopoietic Stem Cells
Embryonic Stem Cells
Regenerative Medicine
Hematologic Diseases
Hematopoietic Stem Cell Transplantation
Embryonic Development
Cell Count
Tissue Donors
Cell culture
Research

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)
  • Cell Biology

Cite this

Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells. / Lim, Wai Feng; Inoue-Yokoo, Tomoko; Tan, Keai Sinn; Lai, Mei I.; Sugiyama, Daisuke.

In: Stem Cell Research and Therapy, Vol. 4, No. 3, 71, 15.07.2013.

Research output: Contribution to journalReview article

Lim, Wai Feng ; Inoue-Yokoo, Tomoko ; Tan, Keai Sinn ; Lai, Mei I. ; Sugiyama, Daisuke. / Hematopoietic cell differentiation from embryonic and induced pluripotent stem cells. In: Stem Cell Research and Therapy. 2013 ; Vol. 4, No. 3.
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