Hematopoietic developmental pathways: On cellular basis

H. Iwasaki, K. Akashi

Research output: Contribution to journalReview article

67 Citations (Scopus)

Abstract

To elucidate the molecular mechanisms underlying normal and malignant hematopoietic development, it is critical to identify developmental intermediates for each lineage downstream of hematopoietic stem cells. Recent advances in prospective isolation of hematopoietic stem and progenitor cells, and efficient xenogeneic transplantation systems have provided a detailed developmental map in both mouse and human hematopoiesis, demonstrating that surface phenotypes of mouse stem-progenitor cells and their human counterparts are considerably different. Here, we summarize the phenotype and functional properties and their differences of hematopoietic stem and progenitor cell populations between mouse and human.

Original languageEnglish
Pages (from-to)6687-6696
Number of pages10
JournalOncogene
Volume26
Issue number47
DOIs
Publication statusPublished - Oct 15 2007

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

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