Hematopoietic stem cell transplantation for natural killer-cell lineage neoplasms

R. Suzuki, J. Suzumiya, S. Nakamura, Y. Kagami, J. I. Kameoka, C. Sakai, H. Mukai, K. Takenaka, T. Yoshino, T. Tsuzuki, H. Sugimori, K. Kawa, Y. Kodera, K. Oshimi

Research output: Contribution to journalArticlepeer-review

97 Citations (Scopus)

Abstract

Neoplasms of natural killer (NK)-lineage are rare. Their prognosis is generally poor except for cases of solitary nasal NK-cell lymphoma. The NK-cell Tumor Study Group performed a survey in Japan on patients diagnosed between 1994 and 1998. Of 228 patients selected for analysis, 40 underwent HSCT (15 allografts and 25 autografts). The underlying diseases were myeloid/NK cell precursor acute leukemia (n = 4), blastic NK-cell lymphoma (n = 11), aggressive NK-cell leukemia (n = 3), and nasal-type extranodal NK-cell lymphoma (n = 22). At the time of HSCT, 22 patients were in complete remission (CR), 11 were in relapse, and seven were primary refractory. All patients received myeloablative conditioning regimens including total-body irradiation. Sixteen died of disease progression, and six of treatment-related causes. Overall, 4-year survival was 39% with a median follow-up of 50 months; this was significantly better than that of patients who did not undergo HSCT (21%, P = 0.0003). For patients transplanted in CR, the 4-year overall survival was 68%, which was significantly better than that of patients who went into CR but did not undergo HSCT (P = 0.03). These findings suggest that the HSCT is a promising treatment strategy for NK-cell lineage.

Original languageEnglish
Pages (from-to)425-431
Number of pages7
JournalBone Marrow Transplantation
Volume37
Issue number4
DOIs
Publication statusPublished - Feb 2006

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

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