Hemodynamic alteration in the liver in acute hepatitis: A quantitative evaluation using computed tomographic perfusion

Akihiro Nishie, Yasuhiro Ushijima, Yukihisa Takayama, Nobuhiro Fujita, Yuichiro Kubo, Keisuke Ishimatsu, Daisuke Tsurumaru, Motoyuki Kohjima, Kousei Ishigami

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aim: We aimed to elucidate the hemodynamic alterations in the liver of patients with acute hepatitis (AH) using computed tomography perfusion imaging. Patients and Methods: For 14 patients with AH and nine patients with no disease (ND group), we compared the mean arterial blood flow (AF), portal blood flow (PF) and perfusion index (%) [PI=AF/(AF+PF) ×100] of the right and left liver lobes and investigated their relationship with clinical factors. Results: The mean PI of the right lobe in the AH group (30.5±10.0%) was significantly higher than that in the ND group (20.8±9.7%) (p=0.031). For all patients of the AH and ND groups, the PI of the right lobe was increased as the prothrombin time decreased (R=-0.56, p=0.006) and as the prothrombin time-international normalized ratio increased (R=0.48, p=0.02). Conclusion: The PI of the right liver lobe may increase in AH and may be a predictive parameter for the severity of hepatic failure.

Original languageEnglish
Pages (from-to)3537-3545
Number of pages9
JournalIn Vivo
Volume35
Issue number6
DOIs
Publication statusPublished - Dec 2021

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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