TY - JOUR
T1 - Hemodynamic alteration in the liver in acute hepatitis
T2 - A quantitative evaluation using computed tomographic perfusion
AU - Nishie, Akihiro
AU - Ushijima, Yasuhiro
AU - Takayama, Yukihisa
AU - Fujita, Nobuhiro
AU - Kubo, Yuichiro
AU - Ishimatsu, Keisuke
AU - Tsurumaru, Daisuke
AU - Kohjima, Motoyuki
AU - Ishigami, Kousei
N1 - Funding Information:
Akihiro Nishie was a staff member of joint research departments in Kyushu University with Canon Medical Systems Corporation. He received a research grant from Canon Medical Systems Corporation. The other Authors have no conflicts of interest.
Funding Information:
The Authors thank Professor Yoshihiro Ogawa, Department of Medicine and Bioregulatory Science, Kyushu University, for providing the clinical information for this article. This study was supported by Canon Medical Systems Corporation.
Publisher Copyright:
© 2021 International Institute of Anticancer Research. All rights reserved.
PY - 2021/12
Y1 - 2021/12
N2 - Background/Aim: We aimed to elucidate the hemodynamic alterations in the liver of patients with acute hepatitis (AH) using computed tomography perfusion imaging. Patients and Methods: For 14 patients with AH and nine patients with no disease (ND group), we compared the mean arterial blood flow (AF), portal blood flow (PF) and perfusion index (%) [PI=AF/(AF+PF) ×100] of the right and left liver lobes and investigated their relationship with clinical factors. Results: The mean PI of the right lobe in the AH group (30.5±10.0%) was significantly higher than that in the ND group (20.8±9.7%) (p=0.031). For all patients of the AH and ND groups, the PI of the right lobe was increased as the prothrombin time decreased (R=-0.56, p=0.006) and as the prothrombin time-international normalized ratio increased (R=0.48, p=0.02). Conclusion: The PI of the right liver lobe may increase in AH and may be a predictive parameter for the severity of hepatic failure.
AB - Background/Aim: We aimed to elucidate the hemodynamic alterations in the liver of patients with acute hepatitis (AH) using computed tomography perfusion imaging. Patients and Methods: For 14 patients with AH and nine patients with no disease (ND group), we compared the mean arterial blood flow (AF), portal blood flow (PF) and perfusion index (%) [PI=AF/(AF+PF) ×100] of the right and left liver lobes and investigated their relationship with clinical factors. Results: The mean PI of the right lobe in the AH group (30.5±10.0%) was significantly higher than that in the ND group (20.8±9.7%) (p=0.031). For all patients of the AH and ND groups, the PI of the right lobe was increased as the prothrombin time decreased (R=-0.56, p=0.006) and as the prothrombin time-international normalized ratio increased (R=0.48, p=0.02). Conclusion: The PI of the right liver lobe may increase in AH and may be a predictive parameter for the severity of hepatic failure.
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U2 - 10.21873/invivo.12656
DO - 10.21873/invivo.12656
M3 - Article
AN - SCOPUS:85119261735
VL - 35
SP - 3537
EP - 3545
JO - In Vivo
JF - In Vivo
SN - 0258-851X
IS - 6
ER -
