Hemodynamic responses to visual stimuli in cortex of adults and 3- to 4-year-old children

Gerard Bastiaan Remijn, Mitsuru Kikuchi, Yuko Yoshimura, Kiyomi Shitamichi, Sanae Ueno, Kikuko Nagao, Toshio Munesue, Haruyuki Kojima, Yoshio Minabe

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

In this study we used near-infrared spectroscopy (NIRS) to measure relative changes in cortical hemodynamics from 19 adult and 19 preschool children (aged 3-4 years old), while they watched epochs of static and motion pictures extracted from TV programs. The spatio-temporal characteristics of oxygenated and deoxygenated hemoglobin volumes (oxy- and deoxy-Hb) of both subject groups were described and compared where appropriate for five regions of interest (ROIs). These were striate, left and right middle temporal, and left and right temporo-parietal areas. Over these areas, deoxy-Hb volumes did not differ between both groups. Preschool data showed significant increases in oxy-Hb over striate, middle temporal and temporo-parietal areas in response to visual motion stimuli. Static stimuli caused a significant oxy-Hb increase over striate and left middle temporal areas. Surprisingly, changes in adult oxy-Hb were not profound and did not show a significant oxy-Hb increase in striate and middle temporal areas in response to the motion stimuli, warranting further research. In spite of oxy-Hb volume differences, oxy-Hb recovery to baseline followed a similar pattern in both groups in response to both static and motion stimuli. Together, the results suggest that near-infrared spectroscopy is a viable method to investigate cortical development of preschool children by monitoring their hemodynamic response patterns.

Original languageEnglish
Pages (from-to)242-251
Number of pages10
JournalBrain Research
Volume1383
DOIs
Publication statusPublished - Apr 6 2011

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Hemodynamics
Near-Infrared Spectroscopy
Preschool Children
Motion Pictures
Hemoglobins
Research

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

Remijn, G. B., Kikuchi, M., Yoshimura, Y., Shitamichi, K., Ueno, S., Nagao, K., ... Minabe, Y. (2011). Hemodynamic responses to visual stimuli in cortex of adults and 3- to 4-year-old children. Brain Research, 1383, 242-251. https://doi.org/10.1016/j.brainres.2011.01.090

Hemodynamic responses to visual stimuli in cortex of adults and 3- to 4-year-old children. / Remijn, Gerard Bastiaan; Kikuchi, Mitsuru; Yoshimura, Yuko; Shitamichi, Kiyomi; Ueno, Sanae; Nagao, Kikuko; Munesue, Toshio; Kojima, Haruyuki; Minabe, Yoshio.

In: Brain Research, Vol. 1383, 06.04.2011, p. 242-251.

Research output: Contribution to journalArticle

Remijn, GB, Kikuchi, M, Yoshimura, Y, Shitamichi, K, Ueno, S, Nagao, K, Munesue, T, Kojima, H & Minabe, Y 2011, 'Hemodynamic responses to visual stimuli in cortex of adults and 3- to 4-year-old children', Brain Research, vol. 1383, pp. 242-251. https://doi.org/10.1016/j.brainres.2011.01.090
Remijn, Gerard Bastiaan ; Kikuchi, Mitsuru ; Yoshimura, Yuko ; Shitamichi, Kiyomi ; Ueno, Sanae ; Nagao, Kikuko ; Munesue, Toshio ; Kojima, Haruyuki ; Minabe, Yoshio. / Hemodynamic responses to visual stimuli in cortex of adults and 3- to 4-year-old children. In: Brain Research. 2011 ; Vol. 1383. pp. 242-251.
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