Hemogenic endothelium: A vessel for blood production

Veronica I. Antas, Mohammad A. Al-Drees, Alexander J.A. Prudence, Daisuke Sugiyama, Stuart T. Fraser

    Research output: Contribution to journalShort surveypeer-review

    20 Citations (Scopus)

    Abstract

    Blood cell production, or hematopoiesis, is critical to the survival of the developing mammalian embryo. The origins of hematopoietic stem cells, capable of giving rise to all blood cell types, are being revealed. During embryogenesis, hematopoietic stem and progenitor cells are generated from a unique population of vascular endothelium termed hemogenic endothelial cells. These unusual endothelial cells are found in a restricted number of sites in the conceptus and within a narrow window of embryonic development. Loss of hemogenic endothelial cells through gene ablation leads to a lack of blood production and embryonic lethality. Here, we describe historical and recent observations exploring the biology of these intriguing endothelial cells and their roles in hematopoiesis both in the embryo and, possibly, in the adult. Crown

    Original languageEnglish
    Pages (from-to)692-695
    Number of pages4
    JournalInternational Journal of Biochemistry and Cell Biology
    Volume45
    Issue number3
    DOIs
    Publication statusPublished - Jan 1 2013

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Cell Biology

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