HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans

Takeshi Ishihara, Yuichi Iino, Akiko Mohri, Ikue Mori, Keiko Gengyo-Ando, Shohei Mitani, Isao Katsura

Research output: Contribution to journalArticle

101 Citations (Scopus)

Abstract

Animals sense many environmental stimuli simultaneously and integrate various sensory signals within the nervous system both to generate proper behavioral responses and also to form relevant memories. HEN-1, a secretory protein with an LDL receptor motif, regulates such processes in Caenorhabditis elegans. The hen-1 mutants show defects in the integration of two sensory signals and in behavioral plasticity by paired stimuli, although their sensation capability seems to be identical to that of the wild-type. The HEN-1 protein is expressed in two pairs of neurons, but expression in other neurons is sufficient for wild-type behavior. In addition, expression of HEN-1 at the adult stage is sufficient. Thus, HEN-1 regulates sensory processing non-cell-autonomously in the mature neuronal circuit.

Original languageEnglish
Pages (from-to)639-649
Number of pages11
JournalCell
Volume109
Issue number5
DOIs
Publication statusPublished - May 31 2002
Externally publishedYes

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LDL Receptors
Caenorhabditis elegans
Neurons
Learning
Neurology
Nervous System
Plasticity
Animals
Proteins
Data storage equipment
Defects
Networks (circuits)
Processing

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans. / Ishihara, Takeshi; Iino, Yuichi; Mohri, Akiko; Mori, Ikue; Gengyo-Ando, Keiko; Mitani, Shohei; Katsura, Isao.

In: Cell, Vol. 109, No. 5, 31.05.2002, p. 639-649.

Research output: Contribution to journalArticle

Ishihara, Takeshi ; Iino, Yuichi ; Mohri, Akiko ; Mori, Ikue ; Gengyo-Ando, Keiko ; Mitani, Shohei ; Katsura, Isao. / HEN-1, a secretory protein with an LDL receptor motif, regulates sensory integration and learning in Caenorhabditis elegans. In: Cell. 2002 ; Vol. 109, No. 5. pp. 639-649.
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AU - Katsura, Isao

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