Hen egg-white lysozyme inhibits biological activities of lipopolysaccharides from periodontopathic bacteria

H. O. Ito, M. Hirata, T. Koga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Lysozyme has a bactericidal activity for some strains of Gram-positive bacteria, by enzymatic cleavage of peptidoglycans that constitute the cell wall. Hen egg-white lysozyme (HEL) was tested in vitro for effects on biological activities of lipopolysaccharides from periodontopathic Gram-negative bacteria, Actinobacillus actinomycetemcomitans, Prevotella intermedia and Porphyromonas gingivalis. HEL inhibited a wide range of activities of these lipopolysaccharides, including activation of Limulus amoebocyte lysate, stimulation of human leukocytes to secrete tumour necrosis factor-alpha, polyclonal activation of mouse B cells, and promotion of osteoclastic differentiation in mouse bone marrow cultures. The anti-endotoxic activity of HEL may be worthy of being intended for periodontal therapy.

Original languageEnglish
Pages (from-to)295-299
Number of pages5
JournalJournal of Periodontal Research
Volume32
Issue number3
DOIs
Publication statusPublished - Apr 1997

All Science Journal Classification (ASJC) codes

  • Periodontics

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