Hepatic interferon-gamma-induced protein-10 expression is more strongly associated with liver fibrosis than interleukin-28B single nucleotide polymorphisms in hepatocellular carcinoma resected patients with chronic hepatitis C

Hideyuki Konishi, Ken Shirabe, Shohei Yoshiya, Tetsuo Ikeda, Toru Ikegami, Tomoharu Yoshizumi, Ayae Ikawa-Yoshida, Takashi Motomura, Takasuke Fukuhara, Yoshihiko Maehara

Research output: Contribution to journalArticle

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Abstract

Aim: Single nucleotide polymorphisms (SNP) around IL-28B and interferon (IFN)-stimulated gene (ISG) expression are predictors of response to standard therapy involving IFN for chronic hepatitis C virus (HCV) infection. We analyzed the association between these predictors to improve the prediction of the response to IFN therapy after liver resection for hepatocellular carcinoma (HCC). Methods: Data were collected from 74 patients with HCV-induced HCC. The IL-28B genotype and hepatic ISG mRNA levels were analyzed to clarify their association, focusing on the progression of liver fibrosis. Results: Fifty patients were identified as having major alleles (rs8099917TT) and the remaining 24 patients had minor alleles (rs8099917TG or GG). Hepatic ISG15 expression was lower in the IL-28B major group than that in the IL-28B minor group (P<0.005). IP-10 expression was similar between the IL-28B major and minor groups (P=0.44). IP-10 expression was elevated with advancing stages of liver fibrosis in HCV infected patients (P=0.005). In patients with mild or no fibrosis, the IL-28B major group had lower IP-10 expression than the IL-28B minor group (P=0.02). However, in patients with advanced fibrosis, IP-10 expression was not different between the IL-28B major and minor groups (P=0.66). Conclusion: Hepatic ISG15 expression is associated with IL-28B polymorphisms, while IP-10 is strongly affected by liver fibrosis.

Original languageEnglish
Pages (from-to)1139-1147
Number of pages9
JournalHepatology Research
Volume43
Issue number11
DOIs
Publication statusPublished - Nov 1 2013

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Interleukins
Chronic Hepatitis C
Liver Cirrhosis
Interferon-gamma
Single Nucleotide Polymorphism
Hepatocellular Carcinoma
Liver
Hepacivirus
Interferons
Proteins
Fibrosis
Alleles
Virus Diseases
Interleukin-10
Genotype
Gene Expression
Messenger RNA
Therapeutics
Genes

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases

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Hepatic interferon-gamma-induced protein-10 expression is more strongly associated with liver fibrosis than interleukin-28B single nucleotide polymorphisms in hepatocellular carcinoma resected patients with chronic hepatitis C. / Konishi, Hideyuki; Shirabe, Ken; Yoshiya, Shohei; Ikeda, Tetsuo; Ikegami, Toru; Yoshizumi, Tomoharu; Ikawa-Yoshida, Ayae; Motomura, Takashi; Fukuhara, Takasuke; Maehara, Yoshihiko.

In: Hepatology Research, Vol. 43, No. 11, 01.11.2013, p. 1139-1147.

Research output: Contribution to journalArticle

Konishi, Hideyuki ; Shirabe, Ken ; Yoshiya, Shohei ; Ikeda, Tetsuo ; Ikegami, Toru ; Yoshizumi, Tomoharu ; Ikawa-Yoshida, Ayae ; Motomura, Takashi ; Fukuhara, Takasuke ; Maehara, Yoshihiko. / Hepatic interferon-gamma-induced protein-10 expression is more strongly associated with liver fibrosis than interleukin-28B single nucleotide polymorphisms in hepatocellular carcinoma resected patients with chronic hepatitis C. In: Hepatology Research. 2013 ; Vol. 43, No. 11. pp. 1139-1147.
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abstract = "Aim: Single nucleotide polymorphisms (SNP) around IL-28B and interferon (IFN)-stimulated gene (ISG) expression are predictors of response to standard therapy involving IFN for chronic hepatitis C virus (HCV) infection. We analyzed the association between these predictors to improve the prediction of the response to IFN therapy after liver resection for hepatocellular carcinoma (HCC). Methods: Data were collected from 74 patients with HCV-induced HCC. The IL-28B genotype and hepatic ISG mRNA levels were analyzed to clarify their association, focusing on the progression of liver fibrosis. Results: Fifty patients were identified as having major alleles (rs8099917TT) and the remaining 24 patients had minor alleles (rs8099917TG or GG). Hepatic ISG15 expression was lower in the IL-28B major group than that in the IL-28B minor group (P<0.005). IP-10 expression was similar between the IL-28B major and minor groups (P=0.44). IP-10 expression was elevated with advancing stages of liver fibrosis in HCV infected patients (P=0.005). In patients with mild or no fibrosis, the IL-28B major group had lower IP-10 expression than the IL-28B minor group (P=0.02). However, in patients with advanced fibrosis, IP-10 expression was not different between the IL-28B major and minor groups (P=0.66). Conclusion: Hepatic ISG15 expression is associated with IL-28B polymorphisms, while IP-10 is strongly affected by liver fibrosis.",
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AU - Konishi, Hideyuki

AU - Shirabe, Ken

AU - Yoshiya, Shohei

AU - Ikeda, Tetsuo

AU - Ikegami, Toru

AU - Yoshizumi, Tomoharu

AU - Ikawa-Yoshida, Ayae

AU - Motomura, Takashi

AU - Fukuhara, Takasuke

AU - Maehara, Yoshihiko

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N2 - Aim: Single nucleotide polymorphisms (SNP) around IL-28B and interferon (IFN)-stimulated gene (ISG) expression are predictors of response to standard therapy involving IFN for chronic hepatitis C virus (HCV) infection. We analyzed the association between these predictors to improve the prediction of the response to IFN therapy after liver resection for hepatocellular carcinoma (HCC). Methods: Data were collected from 74 patients with HCV-induced HCC. The IL-28B genotype and hepatic ISG mRNA levels were analyzed to clarify their association, focusing on the progression of liver fibrosis. Results: Fifty patients were identified as having major alleles (rs8099917TT) and the remaining 24 patients had minor alleles (rs8099917TG or GG). Hepatic ISG15 expression was lower in the IL-28B major group than that in the IL-28B minor group (P<0.005). IP-10 expression was similar between the IL-28B major and minor groups (P=0.44). IP-10 expression was elevated with advancing stages of liver fibrosis in HCV infected patients (P=0.005). In patients with mild or no fibrosis, the IL-28B major group had lower IP-10 expression than the IL-28B minor group (P=0.02). However, in patients with advanced fibrosis, IP-10 expression was not different between the IL-28B major and minor groups (P=0.66). Conclusion: Hepatic ISG15 expression is associated with IL-28B polymorphisms, while IP-10 is strongly affected by liver fibrosis.

AB - Aim: Single nucleotide polymorphisms (SNP) around IL-28B and interferon (IFN)-stimulated gene (ISG) expression are predictors of response to standard therapy involving IFN for chronic hepatitis C virus (HCV) infection. We analyzed the association between these predictors to improve the prediction of the response to IFN therapy after liver resection for hepatocellular carcinoma (HCC). Methods: Data were collected from 74 patients with HCV-induced HCC. The IL-28B genotype and hepatic ISG mRNA levels were analyzed to clarify their association, focusing on the progression of liver fibrosis. Results: Fifty patients were identified as having major alleles (rs8099917TT) and the remaining 24 patients had minor alleles (rs8099917TG or GG). Hepatic ISG15 expression was lower in the IL-28B major group than that in the IL-28B minor group (P<0.005). IP-10 expression was similar between the IL-28B major and minor groups (P=0.44). IP-10 expression was elevated with advancing stages of liver fibrosis in HCV infected patients (P=0.005). In patients with mild or no fibrosis, the IL-28B major group had lower IP-10 expression than the IL-28B minor group (P=0.02). However, in patients with advanced fibrosis, IP-10 expression was not different between the IL-28B major and minor groups (P=0.66). Conclusion: Hepatic ISG15 expression is associated with IL-28B polymorphisms, while IP-10 is strongly affected by liver fibrosis.

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