Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus-related cirrhotic patients

Nao Kinjo, Yoshihiro Nagao, Tomohiko Akahoshi, Kamori Masahiro, Naotaka Hashimoto, hideo uehara, Hirohumi Kawanaka, Morimasa Tomikawa, Ken Shirabe, Makoto Hashizume, Yoshihiko Maehara

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Aim: Whether hepatic function can recover in cirrhotic patients after splenectomy remains controversial. Methods: All consecutive Japanese patients with hepatic cirrhosis due to hepatitis C who had undergone elective splenectomy in Kyushu University Hospital between January 2008 and December 2009 were included in this retrospective study. Prothrombin time, serum albumin and total bilirubin concentrations were reviewed before and after splenectomy and analyzed to clarify whether splenectomy improves hepatic function in patients with cirrhosis and to determine the factors predictive of improvement in hepatic function. Results: Prothrombin time and total serum bilirubin concentration improved after splenectomy; however, serum albumin concentrations did not increase significantly. Twelve months after splenectomy, total serum bilirubin had decreased by over 0.3mg/dL in 52.3% of patients and prothrombin time had improved by over 10% in 52.3% of patients. Multiple linear regression analysis identified hepatic vein waveform (HVWF) type I (P=0.0174) and spleen weight (P=0.0394) as independent predictors of improvement in prothrombin time and preoperative total serum bilirubin (P=0.0002) as the only independent predictor of decrease in total bilirubin. Total bilirubin and prothrombin time were significantly improved after splenectomy in patients with HVWF type I, however, they were not improved in patients with HVWF type II. Conclusion: Prothrombin time and total bilirubin improve in approximately half of cirrhotic patients within a year after splenectomy. HVWF type I and splenomegaly may be predictive factors for improvement in prothrombin time after splenectomy in patients with cirrhosis due to hepatitis C.

Original languageEnglish
Pages (from-to)933-941
Number of pages9
JournalHepatology Research
Volume43
Issue number9
DOIs
Publication statusPublished - Sep 1 2013

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Hepatic Veins
Prothrombin Time
Splenomegaly
Splenectomy
Hepacivirus
Bilirubin
Hepatitis C
Serum Albumin
Liver
Fibrosis
Serum
Liver Cirrhosis
Linear Models
Spleen
Retrospective Studies
Regression Analysis
Weights and Measures

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Infectious Diseases

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Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus-related cirrhotic patients. / Kinjo, Nao; Nagao, Yoshihiro; Akahoshi, Tomohiko; Masahiro, Kamori; Hashimoto, Naotaka; uehara, hideo; Kawanaka, Hirohumi; Tomikawa, Morimasa; Shirabe, Ken; Hashizume, Makoto; Maehara, Yoshihiko.

In: Hepatology Research, Vol. 43, No. 9, 01.09.2013, p. 933-941.

Research output: Contribution to journalArticle

Kinjo, N, Nagao, Y, Akahoshi, T, Masahiro, K, Hashimoto, N, uehara, H, Kawanaka, H, Tomikawa, M, Shirabe, K, Hashizume, M & Maehara, Y 2013, 'Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus-related cirrhotic patients', Hepatology Research, vol. 43, no. 9, pp. 933-941. https://doi.org/10.1111/hepr.12040
Kinjo, Nao ; Nagao, Yoshihiro ; Akahoshi, Tomohiko ; Masahiro, Kamori ; Hashimoto, Naotaka ; uehara, hideo ; Kawanaka, Hirohumi ; Tomikawa, Morimasa ; Shirabe, Ken ; Hashizume, Makoto ; Maehara, Yoshihiko. / Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus-related cirrhotic patients. In: Hepatology Research. 2013 ; Vol. 43, No. 9. pp. 933-941.
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T1 - Hepatic vein waveform and splenomegaly predict improvement of prothrombin time after splenectomy in hepatitis C virus-related cirrhotic patients

AU - Kinjo, Nao

AU - Nagao, Yoshihiro

AU - Akahoshi, Tomohiko

AU - Masahiro, Kamori

AU - Hashimoto, Naotaka

AU - uehara, hideo

AU - Kawanaka, Hirohumi

AU - Tomikawa, Morimasa

AU - Shirabe, Ken

AU - Hashizume, Makoto

AU - Maehara, Yoshihiko

PY - 2013/9/1

Y1 - 2013/9/1

N2 - Aim: Whether hepatic function can recover in cirrhotic patients after splenectomy remains controversial. Methods: All consecutive Japanese patients with hepatic cirrhosis due to hepatitis C who had undergone elective splenectomy in Kyushu University Hospital between January 2008 and December 2009 were included in this retrospective study. Prothrombin time, serum albumin and total bilirubin concentrations were reviewed before and after splenectomy and analyzed to clarify whether splenectomy improves hepatic function in patients with cirrhosis and to determine the factors predictive of improvement in hepatic function. Results: Prothrombin time and total serum bilirubin concentration improved after splenectomy; however, serum albumin concentrations did not increase significantly. Twelve months after splenectomy, total serum bilirubin had decreased by over 0.3mg/dL in 52.3% of patients and prothrombin time had improved by over 10% in 52.3% of patients. Multiple linear regression analysis identified hepatic vein waveform (HVWF) type I (P=0.0174) and spleen weight (P=0.0394) as independent predictors of improvement in prothrombin time and preoperative total serum bilirubin (P=0.0002) as the only independent predictor of decrease in total bilirubin. Total bilirubin and prothrombin time were significantly improved after splenectomy in patients with HVWF type I, however, they were not improved in patients with HVWF type II. Conclusion: Prothrombin time and total bilirubin improve in approximately half of cirrhotic patients within a year after splenectomy. HVWF type I and splenomegaly may be predictive factors for improvement in prothrombin time after splenectomy in patients with cirrhosis due to hepatitis C.

AB - Aim: Whether hepatic function can recover in cirrhotic patients after splenectomy remains controversial. Methods: All consecutive Japanese patients with hepatic cirrhosis due to hepatitis C who had undergone elective splenectomy in Kyushu University Hospital between January 2008 and December 2009 were included in this retrospective study. Prothrombin time, serum albumin and total bilirubin concentrations were reviewed before and after splenectomy and analyzed to clarify whether splenectomy improves hepatic function in patients with cirrhosis and to determine the factors predictive of improvement in hepatic function. Results: Prothrombin time and total serum bilirubin concentration improved after splenectomy; however, serum albumin concentrations did not increase significantly. Twelve months after splenectomy, total serum bilirubin had decreased by over 0.3mg/dL in 52.3% of patients and prothrombin time had improved by over 10% in 52.3% of patients. Multiple linear regression analysis identified hepatic vein waveform (HVWF) type I (P=0.0174) and spleen weight (P=0.0394) as independent predictors of improvement in prothrombin time and preoperative total serum bilirubin (P=0.0002) as the only independent predictor of decrease in total bilirubin. Total bilirubin and prothrombin time were significantly improved after splenectomy in patients with HVWF type I, however, they were not improved in patients with HVWF type II. Conclusion: Prothrombin time and total bilirubin improve in approximately half of cirrhotic patients within a year after splenectomy. HVWF type I and splenomegaly may be predictive factors for improvement in prothrombin time after splenectomy in patients with cirrhosis due to hepatitis C.

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