TY - JOUR
T1 - Hepatitis-associated aplastic anemia during a primary infection of genotype 1a torque teno virus
AU - Ishimura, Masataka
AU - Ohga, Shouichi
AU - Ichiyama, Masako
AU - Kusuhara, Koichi
AU - Takada, Hidetoshi
AU - Hara, Toshiro
AU - Takahashi, Masaharu
AU - Okamoto, Hiroaki
N1 - Funding Information:
Financial support This work was supported in part by a Grant-in-Aid for Scientific Research (C) to Ohga S from the Ministry of Education, Culture, Sports, Science, and Technology of Japan.
PY - 2010/7
Y1 - 2010/7
N2 - A 12-year-old Japanese boy suffered from severe acute hepatitis and pancytopenia. The patient underwent successful bone marrow transplantation from an HLA-identical sister. Torque teno virus (TTV) DNA of genotype 1a and IgM-class antibody against the virus were detected in sera at the onset of hepatitis. TTV/1a DNA and anti-TTV/1a IgM antibody levels were undetectable on the 16th and 46th days after the onset of illness, respectively. Anti-TTV/1a IgG antibody was positive throughout the observation period. Sequential viral load and anti-TTV/1a IgM antibody suggested a primary infection of TTV/1a. Genomic sequence of the virus coincided with that of the original strain first isolated from human. TTV DNA was quantified at 130 copies in 105 bone marrow mononuclear cells, which suggested that infection of hematopoietic cells might be the cause of aplasia. This is the first report of TTV hepatitis-associated aplastic anemia assessed by the anti-TTV antibodies and viral load in peripheral blood and bone marrow.
AB - A 12-year-old Japanese boy suffered from severe acute hepatitis and pancytopenia. The patient underwent successful bone marrow transplantation from an HLA-identical sister. Torque teno virus (TTV) DNA of genotype 1a and IgM-class antibody against the virus were detected in sera at the onset of hepatitis. TTV/1a DNA and anti-TTV/1a IgM antibody levels were undetectable on the 16th and 46th days after the onset of illness, respectively. Anti-TTV/1a IgG antibody was positive throughout the observation period. Sequential viral load and anti-TTV/1a IgM antibody suggested a primary infection of TTV/1a. Genomic sequence of the virus coincided with that of the original strain first isolated from human. TTV DNA was quantified at 130 copies in 105 bone marrow mononuclear cells, which suggested that infection of hematopoietic cells might be the cause of aplasia. This is the first report of TTV hepatitis-associated aplastic anemia assessed by the anti-TTV antibodies and viral load in peripheral blood and bone marrow.
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U2 - 10.1007/s00431-009-1116-8
DO - 10.1007/s00431-009-1116-8
M3 - Article
C2 - 19998044
AN - SCOPUS:77954427388
SN - 0340-6199
VL - 169
SP - 899
EP - 902
JO - Acta Paediatrica Hungarica
JF - Acta Paediatrica Hungarica
IS - 7
ER -
