Hepatitis B Virus Infection: Current Trends and Issues

Norihiro Furusyo, Motohiro Shimizu, Eiichi Ogawa, Murata Masayuki, Jun Hayashi

Research output: Contribution to journalReview article

Abstract

Hepatitis B virus (HBV) infection is a global public health problem. HBV has been classified into eight genotypes (A to H) based on complete nucleotide sequencing. The prevalence of specific genotype varies geographically. The rationale for treatment in patients with chronic hepatitis B is to reduce the risk of progressive chronic liver disease, such as cirrhosis and hepatocellular carcinoma. Treatment strategies for chronic HBV infection include interferon and nucleotide analogues (lamivudine, adefovir dipivoxil, entecavir, and tenofovir disoproxil). HBV persists in the body even after serological recovery from acute hepatitis B. Thus, individuals who have been exposed to HBV are at risk of the reactivation of infection, which may result in an increase in serum aminotransferases or a flare when the immune response is suppressed. Patients requiring immunosuppressive therapy should undergo serologic testing for markers of HBV infection. This topic review summarizes these issues related to the management of hepatitis B.

Original languageEnglish
Pages (from-to)755-761
Number of pages7
JournalRinsho byori. The Japanese journal of clinical pathology
Volume63
Issue number6
Publication statusPublished - Jun 1 2015

Fingerprint

Virus Diseases
Hepatitis B virus
Tenofovir
Chronic Hepatitis B
Hepatitis B
Nucleotides
Genotype
Lamivudine
Immunosuppressive Agents
Transaminases
Interferons
Liver Diseases
Hepatocellular Carcinoma
Fibrosis
Chronic Disease
Therapeutics
Public Health
Infection
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Hepatitis B Virus Infection : Current Trends and Issues. / Furusyo, Norihiro; Shimizu, Motohiro; Ogawa, Eiichi; Masayuki, Murata; Hayashi, Jun.

In: Rinsho byori. The Japanese journal of clinical pathology, Vol. 63, No. 6, 01.06.2015, p. 755-761.

Research output: Contribution to journalReview article

Furusyo, Norihiro ; Shimizu, Motohiro ; Ogawa, Eiichi ; Masayuki, Murata ; Hayashi, Jun. / Hepatitis B Virus Infection : Current Trends and Issues. In: Rinsho byori. The Japanese journal of clinical pathology. 2015 ; Vol. 63, No. 6. pp. 755-761.
@article{129ffdf648a94b9f938fedf3b9741f2e,
title = "Hepatitis B Virus Infection: Current Trends and Issues",
abstract = "Hepatitis B virus (HBV) infection is a global public health problem. HBV has been classified into eight genotypes (A to H) based on complete nucleotide sequencing. The prevalence of specific genotype varies geographically. The rationale for treatment in patients with chronic hepatitis B is to reduce the risk of progressive chronic liver disease, such as cirrhosis and hepatocellular carcinoma. Treatment strategies for chronic HBV infection include interferon and nucleotide analogues (lamivudine, adefovir dipivoxil, entecavir, and tenofovir disoproxil). HBV persists in the body even after serological recovery from acute hepatitis B. Thus, individuals who have been exposed to HBV are at risk of the reactivation of infection, which may result in an increase in serum aminotransferases or a flare when the immune response is suppressed. Patients requiring immunosuppressive therapy should undergo serologic testing for markers of HBV infection. This topic review summarizes these issues related to the management of hepatitis B.",
author = "Norihiro Furusyo and Motohiro Shimizu and Eiichi Ogawa and Murata Masayuki and Jun Hayashi",
year = "2015",
month = "6",
day = "1",
language = "English",
volume = "63",
pages = "755--761",
journal = "Rinsho byori. The Japanese journal of clinical pathology",
issn = "0047-1860",
publisher = "Nihon Rinsho Byori Gakkai",
number = "6",

}

TY - JOUR

T1 - Hepatitis B Virus Infection

T2 - Current Trends and Issues

AU - Furusyo, Norihiro

AU - Shimizu, Motohiro

AU - Ogawa, Eiichi

AU - Masayuki, Murata

AU - Hayashi, Jun

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Hepatitis B virus (HBV) infection is a global public health problem. HBV has been classified into eight genotypes (A to H) based on complete nucleotide sequencing. The prevalence of specific genotype varies geographically. The rationale for treatment in patients with chronic hepatitis B is to reduce the risk of progressive chronic liver disease, such as cirrhosis and hepatocellular carcinoma. Treatment strategies for chronic HBV infection include interferon and nucleotide analogues (lamivudine, adefovir dipivoxil, entecavir, and tenofovir disoproxil). HBV persists in the body even after serological recovery from acute hepatitis B. Thus, individuals who have been exposed to HBV are at risk of the reactivation of infection, which may result in an increase in serum aminotransferases or a flare when the immune response is suppressed. Patients requiring immunosuppressive therapy should undergo serologic testing for markers of HBV infection. This topic review summarizes these issues related to the management of hepatitis B.

AB - Hepatitis B virus (HBV) infection is a global public health problem. HBV has been classified into eight genotypes (A to H) based on complete nucleotide sequencing. The prevalence of specific genotype varies geographically. The rationale for treatment in patients with chronic hepatitis B is to reduce the risk of progressive chronic liver disease, such as cirrhosis and hepatocellular carcinoma. Treatment strategies for chronic HBV infection include interferon and nucleotide analogues (lamivudine, adefovir dipivoxil, entecavir, and tenofovir disoproxil). HBV persists in the body even after serological recovery from acute hepatitis B. Thus, individuals who have been exposed to HBV are at risk of the reactivation of infection, which may result in an increase in serum aminotransferases or a flare when the immune response is suppressed. Patients requiring immunosuppressive therapy should undergo serologic testing for markers of HBV infection. This topic review summarizes these issues related to the management of hepatitis B.

UR - http://www.scopus.com/inward/record.url?scp=84955759815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84955759815&partnerID=8YFLogxK

M3 - Review article

C2 - 26548241

AN - SCOPUS:84955759815

VL - 63

SP - 755

EP - 761

JO - Rinsho byori. The Japanese journal of clinical pathology

JF - Rinsho byori. The Japanese journal of clinical pathology

SN - 0047-1860

IS - 6

ER -