Hepatitis B virus-related immune reconstitution inflammatory syndrome in two patients coinfected with human immunodeficiency virus diagnosed with a liver biopsy

Fujiko Mitsumoto; Masayuki Murata; Yoshifumi Kato; Kazuya Ura; Koji Takayama; Satoshi Hiramine; Hiroaki Ikezaki; Motohiro Shimizu; Kazuhiro Toyoda; Eiichi Ogawa; Shinichi Aishima; Norihiro Furusyo; Jun Hayashi

doi:10.2169/internalmedicine.53.2503

Hepatitis B virus-related immune reconstitution inflammatory syndrome in two patients coinfected with human immunodeficiency virus diagnosed with a liver biopsy

Fujiko Mitsumoto, Masayuki Murata, Yoshifumi Kato, Kazuya Ura, Koji Takayama, Satoshi Hiramine, Hiroaki Ikezaki, Motohiro Shimizu, Kazuhiro Toyoda, Eiichi Ogawa, Shinichi Aishima, Norihiro Furusyo, Jun Hayashi

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Abstract

Hepatic flares occurred in two patients with HBV/HIV coinfection following the commencement of antiretroviral therapy (ART). At that time, the HIV RNA and HBV DNA levels had decreased. The results of liver biopsies showed lymphocytic infiltration that was diffusely positive for CD8⁺ T cells in the portal areas and lobules. These findings suggested HBV-related immune reconstitution inflammatory syndrome (IRIS). The alanine aminotransferase levels of both patients gradually decreased with the continuation of ART. Because there are few reports of the liver histology of HBV-related IRIS, these cases provide a better understanding of the pathogenesis of HBV-related IRIS.

Original language	English
Pages (from-to)	2165-2170
Number of pages	6
Journal	Internal Medicine
Volume	53
Issue number	18
DOIs	https://doi.org/10.2169/internalmedicine.53.2503
Publication status	Published - Sept 1 2014

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Internal Medicine

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Mitsumoto, F., Murata, M., Kato, Y., Ura, K., Takayama, K., Hiramine, S., Ikezaki, H., Shimizu, M., Toyoda, K., Ogawa, E., Aishima, S., Furusyo, N., & Hayashi, J. (2014). Hepatitis B virus-related immune reconstitution inflammatory syndrome in two patients coinfected with human immunodeficiency virus diagnosed with a liver biopsy. Internal Medicine, 53(18), 2165-2170. https://doi.org/10.2169/internalmedicine.53.2503

Mitsumoto, F, Murata, M, Kato, Y, Ura, K, Takayama, K , Hiramine, S , Ikezaki, H, Shimizu, M, Toyoda, K , Ogawa, E, Aishima, S, Furusyo, N & Hayashi, J 2014, 'Hepatitis B virus-related immune reconstitution inflammatory syndrome in two patients coinfected with human immunodeficiency virus diagnosed with a liver biopsy', Internal Medicine, vol. 53, no. 18, pp. 2165-2170. https://doi.org/10.2169/internalmedicine.53.2503

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abstract = "Hepatic flares occurred in two patients with HBV/HIV coinfection following the commencement of antiretroviral therapy (ART). At that time, the HIV RNA and HBV DNA levels had decreased. The results of liver biopsies showed lymphocytic infiltration that was diffusely positive for CD8+ T cells in the portal areas and lobules. These findings suggested HBV-related immune reconstitution inflammatory syndrome (IRIS). The alanine aminotransferase levels of both patients gradually decreased with the continuation of ART. Because there are few reports of the liver histology of HBV-related IRIS, these cases provide a better understanding of the pathogenesis of HBV-related IRIS.",

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AU - Mitsumoto, Fujiko

AU - Murata, Masayuki

AU - Kato, Yoshifumi

AU - Ura, Kazuya

AU - Takayama, Koji

AU - Hiramine, Satoshi

AU - Ikezaki, Hiroaki

AU - Shimizu, Motohiro

AU - Toyoda, Kazuhiro

AU - Ogawa, Eiichi

AU - Aishima, Shinichi

AU - Furusyo, Norihiro

AU - Hayashi, Jun

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AB - Hepatic flares occurred in two patients with HBV/HIV coinfection following the commencement of antiretroviral therapy (ART). At that time, the HIV RNA and HBV DNA levels had decreased. The results of liver biopsies showed lymphocytic infiltration that was diffusely positive for CD8+ T cells in the portal areas and lobules. These findings suggested HBV-related immune reconstitution inflammatory syndrome (IRIS). The alanine aminotransferase levels of both patients gradually decreased with the continuation of ART. Because there are few reports of the liver histology of HBV-related IRIS, these cases provide a better understanding of the pathogenesis of HBV-related IRIS.

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Hepatitis B virus-related immune reconstitution inflammatory syndrome in two patients coinfected with human immunodeficiency virus diagnosed with a liver biopsy

Abstract

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