Abstract
Abstract: A 28‐year‐old Japanese woman who suffered from mononeuritis multiplex was admitted to our hospital. Serological study revealed cryoglobulinemia (type III), hypocomplementemia, high titers of rheumatoid factor (RF), and positive antihepatitis C virus (HCV) antibody. Nerve conduction velocities were slower in sensory nerves than in motor nerves. Biopsied sural nerve showed a marked decrease of myelinated fibers but no evidence of angitis. She received plasma exchange and cryoglobulinpheresis over a period of 2 months with approximately 2.0 L (40 ml/kg) of plasma replaced in each procedure. Both plasma exchange and cryoglobulinpheresis alleviated clinical symptoms, and nerve conduction velocities were improved in several nerves. The serum cryoglobulin level was markedly reduced after the treatment together with the recovery of the C4 level. Thus, complements appeared to be consumed in large quantities in the presence of cryoglobulinemia in this patient. Efficacy of cryoglobulinpheresis indicates the possibility that cryoglobulins produced in association with HCV infection played a role in damaging the nerve directly through the activation of the complement system.
| Original language | English |
|---|---|
| Pages (from-to) | 334-338 |
| Number of pages | 5 |
| Journal | Artificial Organs |
| Volume | 19 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jan 1 1995 |
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All Science Journal Classification (ASJC) codes
- Bioengineering
- Medicine (miscellaneous)
- Biomaterials
- Biomedical Engineering
Cite this
Hepatitis C Virus Associated Cryoglobulinemic Neuropathy Successfully Treated with Plasma Exchange. / Murai, Hiroyuki; Inaba, Shoichi; Kira, Jun-Ichi; Yamamoto, Akifumi; Ohno, Masaharu; Goto, Ikuo.
In: Artificial Organs, Vol. 19, No. 4, 01.01.1995, p. 334-338.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Hepatitis C Virus Associated Cryoglobulinemic Neuropathy Successfully Treated with Plasma Exchange
AU - Murai, Hiroyuki
AU - Inaba, Shoichi
AU - Kira, Jun-Ichi
AU - Yamamoto, Akifumi
AU - Ohno, Masaharu
AU - Goto, Ikuo
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Abstract: A 28‐year‐old Japanese woman who suffered from mononeuritis multiplex was admitted to our hospital. Serological study revealed cryoglobulinemia (type III), hypocomplementemia, high titers of rheumatoid factor (RF), and positive antihepatitis C virus (HCV) antibody. Nerve conduction velocities were slower in sensory nerves than in motor nerves. Biopsied sural nerve showed a marked decrease of myelinated fibers but no evidence of angitis. She received plasma exchange and cryoglobulinpheresis over a period of 2 months with approximately 2.0 L (40 ml/kg) of plasma replaced in each procedure. Both plasma exchange and cryoglobulinpheresis alleviated clinical symptoms, and nerve conduction velocities were improved in several nerves. The serum cryoglobulin level was markedly reduced after the treatment together with the recovery of the C4 level. Thus, complements appeared to be consumed in large quantities in the presence of cryoglobulinemia in this patient. Efficacy of cryoglobulinpheresis indicates the possibility that cryoglobulins produced in association with HCV infection played a role in damaging the nerve directly through the activation of the complement system.
AB - Abstract: A 28‐year‐old Japanese woman who suffered from mononeuritis multiplex was admitted to our hospital. Serological study revealed cryoglobulinemia (type III), hypocomplementemia, high titers of rheumatoid factor (RF), and positive antihepatitis C virus (HCV) antibody. Nerve conduction velocities were slower in sensory nerves than in motor nerves. Biopsied sural nerve showed a marked decrease of myelinated fibers but no evidence of angitis. She received plasma exchange and cryoglobulinpheresis over a period of 2 months with approximately 2.0 L (40 ml/kg) of plasma replaced in each procedure. Both plasma exchange and cryoglobulinpheresis alleviated clinical symptoms, and nerve conduction velocities were improved in several nerves. The serum cryoglobulin level was markedly reduced after the treatment together with the recovery of the C4 level. Thus, complements appeared to be consumed in large quantities in the presence of cryoglobulinemia in this patient. Efficacy of cryoglobulinpheresis indicates the possibility that cryoglobulins produced in association with HCV infection played a role in damaging the nerve directly through the activation of the complement system.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028898285&partnerID=8YFLogxK
U2 - 10.1111/j.1525-1594.1995.tb02337.x
DO - 10.1111/j.1525-1594.1995.tb02337.x
M3 - Article
VL - 19
SP - 334
EP - 338
JO - Artificial Organs
JF - Artificial Organs
SN - 0160-564X
IS - 4
ER -