Hepatitis G virus in the general population and in patients on hemodialysis

Jun Hayashi, Norihiro Furusyo, Yasunori Sawayama, Yasuhiro Kishihara, Yasunobu Kawakami, Iwao Ariyama, Yoshitaka Etoh, Seizaburo Kashiwagi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

To determine the routes of transmission of hepatitis G virus (HGV) and the relationship between HGV and hepatitis C virus (HCV) infections, we tested for HGV RNA by polymerase chain reaction and antibody to HCV (anti- HCV) in 494 hemodialysis patients, 638 inhabitants of two HCV endemic areas, and in 400 blood donors in Japan. HGV RNA was detected in 6.9% of hemodialysis patients, in 1.4% of inhabitants, and in 0.8% of donors, and anti-HCV was detected in 39.3%, 12.4%, and 1.8%, respectively. Of HGV RNA- positive hemodialysis patients, and HGV RNA-positive inhabitants, 64.7% and 11.1%, respectively, had been given blood transfusions. The prevalences of HGV RNA and anti-HCV significantly increased with the duration of hemodialysis. Of all HGV RNA positives, 74.4% were coinfected with HCV and subjects with HGV RNA alone had normal liver function. In conclusion, HGV is transmitted by blood transfusion and within the hemodialysis unit itself. HGV does not seem to injure hepatocytes.

Original languageEnglish
Pages (from-to)2143-2148
Number of pages6
JournalDigestive Diseases and Sciences
Volume43
Issue number9
DOIs
Publication statusPublished - Oct 5 1998

Fingerprint

GB virus C
Renal Dialysis
Population
Hepacivirus
RNA
Blood Transfusion
Hepatitis C Antibodies
Virus Diseases
DNA-Directed RNA Polymerases
Blood Donors
Hepatocytes
Japan

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Hayashi, J., Furusyo, N., Sawayama, Y., Kishihara, Y., Kawakami, Y., Ariyama, I., ... Kashiwagi, S. (1998). Hepatitis G virus in the general population and in patients on hemodialysis. Digestive Diseases and Sciences, 43(9), 2143-2148. https://doi.org/10.1023/A:1018883920209

Hepatitis G virus in the general population and in patients on hemodialysis. / Hayashi, Jun; Furusyo, Norihiro; Sawayama, Yasunori; Kishihara, Yasuhiro; Kawakami, Yasunobu; Ariyama, Iwao; Etoh, Yoshitaka; Kashiwagi, Seizaburo.

In: Digestive Diseases and Sciences, Vol. 43, No. 9, 05.10.1998, p. 2143-2148.

Research output: Contribution to journalArticle

Hayashi, J, Furusyo, N, Sawayama, Y, Kishihara, Y, Kawakami, Y, Ariyama, I, Etoh, Y & Kashiwagi, S 1998, 'Hepatitis G virus in the general population and in patients on hemodialysis', Digestive Diseases and Sciences, vol. 43, no. 9, pp. 2143-2148. https://doi.org/10.1023/A:1018883920209
Hayashi J, Furusyo N, Sawayama Y, Kishihara Y, Kawakami Y, Ariyama I et al. Hepatitis G virus in the general population and in patients on hemodialysis. Digestive Diseases and Sciences. 1998 Oct 5;43(9):2143-2148. https://doi.org/10.1023/A:1018883920209
Hayashi, Jun ; Furusyo, Norihiro ; Sawayama, Yasunori ; Kishihara, Yasuhiro ; Kawakami, Yasunobu ; Ariyama, Iwao ; Etoh, Yoshitaka ; Kashiwagi, Seizaburo. / Hepatitis G virus in the general population and in patients on hemodialysis. In: Digestive Diseases and Sciences. 1998 ; Vol. 43, No. 9. pp. 2143-2148.
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