Hepatocellular carcinoma with a pseudocapsule on gadolinium- Enhanced MR images: Correlation with histopathologic findings

Kousei Ishigami, Kengo Yoshimitsu, Yunosuke Nishihara, Hiroyuki Irie, Yoshiki Asayama, Tsuyoshi Tajima, Akihiro Nishie, Masakazu Hirakawa, Yasuhiro Ushijima, Daisuke Okamoto, Akinobu Taketomi, Hiroshi Honda

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Abstract

Purpose: To evaluate the characteristics of hepatocellular carcinoma (HCC) with a pseudocapsule on dynamic magnetic resonance (MR) images. Materials and Methods: The institutional review board approval was obtained, and the requirements for informed consent were waived for this retrospective study. Dynamic MR studies of surgically resected 106 HCCs in 93 patients were retrospectively reviewed. A false-positive fibrous capsule (FC) on dynamic MR images was considered to be a pseudocapsule. Pathologic specimens of HCCs with a pseudocapsule were reviewed. The differences in size, tumor grade, the degree of liver fibrosis and background liver diseases, and the incidence of vascular invasion were compared between HCCs with a pseudocapsule on MR images and those with FC at histologic examination by using Student t, Kruskal-Wallis, and χ2 Results: The sensitivity, specificity, and accuracy of dynamic MR in the diagnosis of histologic FC were 94.0% (47 of 50), 73.2% (41 of 56), and 83.0% (88 of 106), respectively. There were 15 (14.2%) HCCs with a pseudocapsule. The pathologic specimens suggested possible causes of the pseudocapsule that included prominent sinusoids (n = 6), peritumoral fibrosis mimicking bridging fibrosis (n = 3), and both (n = 5). In one case, the capsulated HCC was surrounded by a well-differentiated HCC component. The mean size of a HCC with a pseudocapsule tended to be smaller than that with histologic FC, although it was not significant (mean ± standard deviation: 2.8 cm ± 1.0 vs 3.5 cm ± 2.0, P =.09). Liver cirrhosis was less frequent in HCCs with a pseudocapsule than in those with a histologic FC (one of 14 [7.1%] vs 20 of 49 [40.8%], P <.05). The tumor grades were not significantly different, and the incidence of vascular invasion after standardizing the tumor size (<4 cm) was similar (five of 14 [35.7%] vs 12 of 37 [32.4%]).Conclusion: Dynamic MR imaging is accurate in depicting FC in HCCs. HCC with a pseudocapsule at MR possibly consists of peritumoral sinusoids and/or fibrosis. The pseudocapsule may be similar to histologic FC in terms of tumor invasiveness.

Original languageEnglish
Pages (from-to)435-443
Number of pages9
JournalRadiology
Volume250
Issue number2
DOIs
Publication statusPublished - Feb 1 2009

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Gadolinium
Capsules
Hepatocellular Carcinoma
Magnetic Resonance Spectroscopy
Fibrosis
Liver Cirrhosis
Blood Vessels
Neoplasms
Research Ethics Committees
Incidence
Informed Consent
Liver Diseases
Retrospective Studies
Magnetic Resonance Imaging
Students
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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Hepatocellular carcinoma with a pseudocapsule on gadolinium- Enhanced MR images : Correlation with histopathologic findings. / Ishigami, Kousei; Yoshimitsu, Kengo; Nishihara, Yunosuke; Irie, Hiroyuki; Asayama, Yoshiki; Tajima, Tsuyoshi; Nishie, Akihiro; Hirakawa, Masakazu; Ushijima, Yasuhiro; Okamoto, Daisuke; Taketomi, Akinobu; Honda, Hiroshi.

In: Radiology, Vol. 250, No. 2, 01.02.2009, p. 435-443.

Research output: Contribution to journalArticle

Ishigami, Kousei ; Yoshimitsu, Kengo ; Nishihara, Yunosuke ; Irie, Hiroyuki ; Asayama, Yoshiki ; Tajima, Tsuyoshi ; Nishie, Akihiro ; Hirakawa, Masakazu ; Ushijima, Yasuhiro ; Okamoto, Daisuke ; Taketomi, Akinobu ; Honda, Hiroshi. / Hepatocellular carcinoma with a pseudocapsule on gadolinium- Enhanced MR images : Correlation with histopathologic findings. In: Radiology. 2009 ; Vol. 250, No. 2. pp. 435-443.
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abstract = "Purpose: To evaluate the characteristics of hepatocellular carcinoma (HCC) with a pseudocapsule on dynamic magnetic resonance (MR) images. Materials and Methods: The institutional review board approval was obtained, and the requirements for informed consent were waived for this retrospective study. Dynamic MR studies of surgically resected 106 HCCs in 93 patients were retrospectively reviewed. A false-positive fibrous capsule (FC) on dynamic MR images was considered to be a pseudocapsule. Pathologic specimens of HCCs with a pseudocapsule were reviewed. The differences in size, tumor grade, the degree of liver fibrosis and background liver diseases, and the incidence of vascular invasion were compared between HCCs with a pseudocapsule on MR images and those with FC at histologic examination by using Student t, Kruskal-Wallis, and χ2 Results: The sensitivity, specificity, and accuracy of dynamic MR in the diagnosis of histologic FC were 94.0{\%} (47 of 50), 73.2{\%} (41 of 56), and 83.0{\%} (88 of 106), respectively. There were 15 (14.2{\%}) HCCs with a pseudocapsule. The pathologic specimens suggested possible causes of the pseudocapsule that included prominent sinusoids (n = 6), peritumoral fibrosis mimicking bridging fibrosis (n = 3), and both (n = 5). In one case, the capsulated HCC was surrounded by a well-differentiated HCC component. The mean size of a HCC with a pseudocapsule tended to be smaller than that with histologic FC, although it was not significant (mean ± standard deviation: 2.8 cm ± 1.0 vs 3.5 cm ± 2.0, P =.09). Liver cirrhosis was less frequent in HCCs with a pseudocapsule than in those with a histologic FC (one of 14 [7.1{\%}] vs 20 of 49 [40.8{\%}], P <.05). The tumor grades were not significantly different, and the incidence of vascular invasion after standardizing the tumor size (<4 cm) was similar (five of 14 [35.7{\%}] vs 12 of 37 [32.4{\%}]).Conclusion: Dynamic MR imaging is accurate in depicting FC in HCCs. HCC with a pseudocapsule at MR possibly consists of peritumoral sinusoids and/or fibrosis. The pseudocapsule may be similar to histologic FC in terms of tumor invasiveness.",
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T2 - Correlation with histopathologic findings

AU - Ishigami, Kousei

AU - Yoshimitsu, Kengo

AU - Nishihara, Yunosuke

AU - Irie, Hiroyuki

AU - Asayama, Yoshiki

AU - Tajima, Tsuyoshi

AU - Nishie, Akihiro

AU - Hirakawa, Masakazu

AU - Ushijima, Yasuhiro

AU - Okamoto, Daisuke

AU - Taketomi, Akinobu

AU - Honda, Hiroshi

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Y1 - 2009/2/1

N2 - Purpose: To evaluate the characteristics of hepatocellular carcinoma (HCC) with a pseudocapsule on dynamic magnetic resonance (MR) images. Materials and Methods: The institutional review board approval was obtained, and the requirements for informed consent were waived for this retrospective study. Dynamic MR studies of surgically resected 106 HCCs in 93 patients were retrospectively reviewed. A false-positive fibrous capsule (FC) on dynamic MR images was considered to be a pseudocapsule. Pathologic specimens of HCCs with a pseudocapsule were reviewed. The differences in size, tumor grade, the degree of liver fibrosis and background liver diseases, and the incidence of vascular invasion were compared between HCCs with a pseudocapsule on MR images and those with FC at histologic examination by using Student t, Kruskal-Wallis, and χ2 Results: The sensitivity, specificity, and accuracy of dynamic MR in the diagnosis of histologic FC were 94.0% (47 of 50), 73.2% (41 of 56), and 83.0% (88 of 106), respectively. There were 15 (14.2%) HCCs with a pseudocapsule. The pathologic specimens suggested possible causes of the pseudocapsule that included prominent sinusoids (n = 6), peritumoral fibrosis mimicking bridging fibrosis (n = 3), and both (n = 5). In one case, the capsulated HCC was surrounded by a well-differentiated HCC component. The mean size of a HCC with a pseudocapsule tended to be smaller than that with histologic FC, although it was not significant (mean ± standard deviation: 2.8 cm ± 1.0 vs 3.5 cm ± 2.0, P =.09). Liver cirrhosis was less frequent in HCCs with a pseudocapsule than in those with a histologic FC (one of 14 [7.1%] vs 20 of 49 [40.8%], P <.05). The tumor grades were not significantly different, and the incidence of vascular invasion after standardizing the tumor size (<4 cm) was similar (five of 14 [35.7%] vs 12 of 37 [32.4%]).Conclusion: Dynamic MR imaging is accurate in depicting FC in HCCs. HCC with a pseudocapsule at MR possibly consists of peritumoral sinusoids and/or fibrosis. The pseudocapsule may be similar to histologic FC in terms of tumor invasiveness.

AB - Purpose: To evaluate the characteristics of hepatocellular carcinoma (HCC) with a pseudocapsule on dynamic magnetic resonance (MR) images. Materials and Methods: The institutional review board approval was obtained, and the requirements for informed consent were waived for this retrospective study. Dynamic MR studies of surgically resected 106 HCCs in 93 patients were retrospectively reviewed. A false-positive fibrous capsule (FC) on dynamic MR images was considered to be a pseudocapsule. Pathologic specimens of HCCs with a pseudocapsule were reviewed. The differences in size, tumor grade, the degree of liver fibrosis and background liver diseases, and the incidence of vascular invasion were compared between HCCs with a pseudocapsule on MR images and those with FC at histologic examination by using Student t, Kruskal-Wallis, and χ2 Results: The sensitivity, specificity, and accuracy of dynamic MR in the diagnosis of histologic FC were 94.0% (47 of 50), 73.2% (41 of 56), and 83.0% (88 of 106), respectively. There were 15 (14.2%) HCCs with a pseudocapsule. The pathologic specimens suggested possible causes of the pseudocapsule that included prominent sinusoids (n = 6), peritumoral fibrosis mimicking bridging fibrosis (n = 3), and both (n = 5). In one case, the capsulated HCC was surrounded by a well-differentiated HCC component. The mean size of a HCC with a pseudocapsule tended to be smaller than that with histologic FC, although it was not significant (mean ± standard deviation: 2.8 cm ± 1.0 vs 3.5 cm ± 2.0, P =.09). Liver cirrhosis was less frequent in HCCs with a pseudocapsule than in those with a histologic FC (one of 14 [7.1%] vs 20 of 49 [40.8%], P <.05). The tumor grades were not significantly different, and the incidence of vascular invasion after standardizing the tumor size (<4 cm) was similar (five of 14 [35.7%] vs 12 of 37 [32.4%]).Conclusion: Dynamic MR imaging is accurate in depicting FC in HCCs. HCC with a pseudocapsule at MR possibly consists of peritumoral sinusoids and/or fibrosis. The pseudocapsule may be similar to histologic FC in terms of tumor invasiveness.

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